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Sialic acid binding Ig-like lectin 8

Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010] (from NCBI)
Top mentioned proteins: ACID, CD33, p75, MAST, IgE
Papers on Siglec-8
Biomarkers of eosinophil involvement in allergic and eosinophilic diseases: review of phenotypic and serum markers including a novel assay to quantify levels of soluble Siglec-8.
GeneRIF
Bochner et al., Baltimore, United States. In J Immunol Methods, 2012
Report the development of a sensitive competitive ELISA to detect sSiglec-8 in human serum samples obtained from patients with various forms of eosinophilia.
IL-33 enhances Siglec-8 mediated apoptosis of human eosinophils.
GeneRIF
Bochner et al., Baltimore, United States. In Cytokine, 2012
Eosinophils primed by IL-33 and/or IL-5 in vivo would be expected to display enhanced susceptibility to undergoing Siglec-8-induced apoptosis.
Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil siglec-8 expression.
GeneRIF
Bochner et al., Baltimore, United States. In J Clin Immunol, 2011
expressed on eosinophils and basophils from subjects with chronic eosinophilic leukemia, chronic myelogenous leukemia, and on malignant and non-malignant bone marrow mast cells
Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma.
GeneRIF
Bochner et al., Baltimore, United States. In Eur J Hum Genet, 2010
The Siglec-8 gene may be a susceptibility locus for asthma.
Mast cells: makers and breakers of allergic inflammation.
Review
Maurer et al., Berlin, Germany. In Curr Opin Allergy Clin Immunol, 2009
For example, the newly discovered siglec-8 receptor might act as an inhibitor of mast cell degranulation and thus of mast cell-mediated allergic inflammation.
Eosinophil-selective binding and proapoptotic effect in vitro of a synthetic Siglec-8 ligand, polymeric 6'-sulfated sialyl Lewis x.
GeneRIF
Bochner et al., Baltimore, United States. In J Pharmacol Exp Ther, 2009
Selective and specific engagement and binding of Siglec-8 on eosinophils by a synthetic 6'-sulfo-sLe(x)-containing ligand could be useful for controlling eosinophilic inflammatory responses in vivo.
Interleukin-5 priming of human eosinophils alters siglec-8 mediated apoptosis pathways.
GeneRIF
Bochner et al., Baltimore, United States. In Am J Respir Cell Mol Biol, 2008
IL-5 priming enhances Siglec-8-mediated mitochondrial and ROS-dependent eosinophil apoptosis and eliminates caspase dependence.
Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides.
Bovin et al., Moscow, Russia. In Biochemistry (mosc), 2006
It was shown that sulfate derivatives of LacNAc did not bind siglecs-1, -4, -5, -6, -7, -8, -9, and -10; binding of 6'-O-Su-LacNAc to siglec-8 was stronger than binding of 3'SiaLacNAc.
A comparative study of the asparagine-linked oligosaccharides on siglec-5, siglec-7 and siglec-8, expressed in a CHO cell line, and their contribution to ligand recognition.
Camilleri et al., Oxford, United Kingdom. In Eur J Biochem, 2001
In addition to the previously characterized siglecs, sialoadhesin, CD22, CD33 and myelin-associated glycoprotein, several new ones, siglec-5, siglec-7 and siglec-8, have recently been cloned.
Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene.
Diamandis et al., Toronto, Canada. In Biochem Biophys Res Commun, 2000
Further, we have identified a novel Siglec8 variant, named Siglec8-Long (Siglec8-L), which differs in its last two exons from the previously published mRNA sequence of Siglec8 (GenBank Accession No. AF195092).
Identification and molecular characterization of a novel member of the siglec family (SIGLEC9).
Diamandis et al., Toronto, Canada. In Genomics, 2000
This novel siglec shows a high degree of homology to many members of the siglec family, including siglec-7 (80%), siglec-8 (72%), siglec-5 (65%), and CD33 (64%).
Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily.
Crocker et al., Dundee, United Kingdom. In J Biol Chem, 2000
We describe the characterization of siglec-8, a novel sialic acid-binding immunoglobulin-like lectin that is expressed specifically by eosinophils.
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