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Sialic acid binding Ig-like lectin 10

Siglec-10, hSiglec-10, Pro-940
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002] (from NCBI)
Top mentioned proteins: ACID, CD33, CD11b, AGE, CD16
Papers on Siglec-10
Epigenome-Wide Association Study of Aggressive Behavior.
New
Boomsma et al., Amsterdam, Netherlands. In Twin Res Hum Genet, Dec 2015
Here the top sites were cg21557159 (chr 11; 107,795,699, nearest gene = RAB39, p = 5.7 × 10-6, FDR = 0.99), cg08648367 (chr 19; 51,925,472, nearest gene = SIGLEC10, p = 7.6 × 10-6, FDR = 0.99), and cg14212412 (chr 6; 105,918,992, nearest gene = PREP, p = 8.0 × 10-6, FDR = 0.99).
SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders.
Ghia et al., Milano, Italy. In Haematologica, 2014
In keeping with these findings we have also observed a remarkable down-regulation of the human ortholog SIGLEC10 in human B-cell lymphoma and leukemia cell lines.
Discovery of candidate genes for muscle traits based on GWAS supported by eQTL-analysis.
Wimmers et al., Germany. In Int J Biol Sci, 2013
These SNPs on SSC4 showed association with expression levels of ZNF704, IMPA1, and OXSR1; SSC6 SNPs were associated with expression of SIGLEC10 and PIH1D1.
Click and pick: identification of sialoside analogues for siglec-based cell targeting.
Paulson et al., Los Angeles, United States. In Angew Chem Int Ed Engl, 2012
Microarray printing of the library and screening with the siglec family of sialic-acid-binding proteins, led to the identification of high-affinity ligands for siglec-9 and siglec-10.
Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction.
Impact
Liu et al., Ann Arbor, United States. In Nat Biotechnol, 2011
In mice, inflammatory responses to host danger-associated molecular patterns (DAMPs), but not to microbial pathogen-associated molecular patterns (PAMPs), are repressed by the interaction [corrected] of CD24 and SiglecG (SIGLEC10 in human).
Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate.
GeneRIF
Jalkanen et al., Turku, Finland. In Blood, 2010
Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium
Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets.
Gabuzda et al., Montréal, Canada. In Bmc Genomics, 2008
CD16+ Mo were distinguished by upregulation of transcripts for dendritic cell (DC) (SIGLEC10, CD43, RARA) and macrophage (MPhi) (CSF1R/CD115, MafB, CD97, C3aR) markers together with transcripts relevant for DC-T cell interaction (CXCL16, ICAM-2, LFA-1), cell activation (LTB, TNFRSF8, LST1, IFITM1-3, HMOX1, SOD-1, WARS, MGLL), and negative regulation of the cell cycle (CDKN1C, MTSS1), whereas CD16- Mo were distinguished by upregulation of transcripts for myeloid (CD14, MNDA, TREM1, CD1d, C1qR/CD93) and granulocyte markers (FPR1, GCSFR/CD114, S100A8-9/12).
Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.
GeneRIF
Platzer et al., Jena, Germany. In Genome Biol, 2006
the apparent occurrence of an unusual TG 3' splice site in intron 11 is discussed
Ganglioside binding pattern of CD33-related siglecs.
Bovin et al., Moscow, Russia. In Bioorg Med Chem Lett, 2003
Siglec-5 bound preferentially to GQ1b, but weakly to GT1b, whereas siglec-10 interacted only with GT1b ganglioside.
Biochemical defects in retina-specific human ATP binding cassette transporter nucleotide binding domain 1 mutants associated with macular degeneration.
Biswas et al., Philadelphia, United States. In J Biol Chem, 2002
In this communication, we present a quantitative study analyzing the effects of certain disease-associated mutations, Gly-863 --> Ala, Pro-940 --> Arg, and Arg-943 --> Gln on the nucleotide binding, and general ribonucleotidase activities of this domain.
A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33.
Longphre et al., Princeton, United States. In Eur J Biochem, 2001
Siglec-10 was identified through database mining of an asthmatic eosinophil EST library.
Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters.
Varki et al., San Diego, United States. In J Biol Chem, 2001
The other Siglec-3-like gene in the cluster (mSiglec-G) is probably a hSiglec-10 ortholog.
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