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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Single immunoglobulin and toll-interleukin 1 receptor

SIGIRR, TIR8
Top mentioned proteins: IL-1beta, IL-1ra, TLR4, CAN, Interleukin-6
Papers on SIGIRR
Thrombomodulin Protects Against Bacterial Keratitis, Is Anti-Inflammatory, but Not Angiogenic.
New
Hazlett et al., In Invest Ophthalmol Vis Sci, Jan 2016
Corneal mRNA levels for HMGB1 were unchanged, but proinflammatory molecules IL-1β, CXCL2, NF-κB, TLR4, and RAGE were decreased; anti-inflammatory molecules SIGIRR and ST2 were increased.
Human Colon Tumors Express a Dominant-Negative Form of SIGIRR That Promotes Inflammation and Colitis-Associated Colon Cancer in Mice.
New
Li et al., Cleveland, United States. In Gastroenterology, Dec 2015
BACKGROUND & AIMS: Single immunoglobulin and toll-interleukin 1 receptor (SIGIRR), a negative regulator of the Toll-like and interleukin-1 receptor (IL-1R) signaling pathways, controls intestinal inflammation and suppresses colon tumorigenesis in mice.
Allergic airway inflammation: unravelling the relationship between IL-37, IL-18Rα and Tir8/SIGIRR.
Review
New
Wegmann et al., Germany. In Expert Rev Respir Med, Dec 2015
The IL-1 cytokine family and its receptor systems comprise a variety of proinflammatory cytokines like IL-1β and IL-18 and anti-inflammatory molecules such as the Toll/interleukin-1 receptor 8/single Ig IL-1 receptor (IL-R)-related molecule (Tir8/SIGIRR) and the recently established cytokine IL-37.
SIGIRR/TIR8, an important regulator of TLR4 and IL-1R-mediated NF-κB activation, predicts biochemical recurrence after prostatectomy in low-grade prostate carcinomas.
New
Ricke et al., Madison, United States. In Hum Pathol, Nov 2015
Single Ig IL-1-related receptor (SIGIRR) is a negative regulator of toll-like receptor 4 and IL-1-mediated activation of nuclear factor κ-light-chain enhancer of activated B cells.
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.
New
Impact
Nold et al., Melbourne, Australia. In Nat Immunol, Apr 2015
Interleukin 37 (IL-37) and IL-1R8 (SIGIRR or TIR8) are anti-inflammatory orphan members of the IL-1 ligand family and IL-1 receptor family, respectively.
Insights into Campylobacter jejuni colonization of the mammalian intestinal tract using a novel mouse model of infection.
Review
Vallance et al., Colombia. In Gut Microbes, 2014
We recently published that mice deficient in Single IgG Interleukin-1 related receptor (SIGIRR), a repressor of MyD88-dependent innate immune signaling, were highly susceptible to enteric infection by murine bacterial pathogens.
SIGIRR participates in negative regulation of LPS response and tolerance in human bladder epithelial cells.
Chen et al., Shenyang, China. In Bmc Immunol, 2014
Previous studies have demonstrated that single immunoglobulin IL-1R-related receptor/Toll IL-1 receptor 8 (SIGIRR/TIR8) is a member of the toll-interleukin-1 receptor (TIR) family that can negatively modulate TLR4 mediated signaling, but its role in the innate immunity of urinary tract infection remains incompletely defined.
Toll-Like Receptor Family Polymorphisms Are Associated with Primary Renal Diseases but Not with Renal Outcomes Following Kidney Transplantation.
Leemans et al., Amsterdam, Netherlands. In Plos One, 2014
We studied twelve non-synonymous single nucleotide polymorphisms (SNPs) of which eleven in TLR1-8 and one in SIGIRR in a final cohort comprising 1116 matching donors and recipients.
Anti-Inflamm-Aging Effects of Long-Term Caloric Restriction via Overexpression of SIGIRR to Inhibit NF-x03BA;B Signaling Pathway.
Chen et al., In Cell Physiol Biochem, 2014
2) Single immunoglobulin IL-1 (IL-1)-related receptor (SIGIRR) expression decreased with increasing age, but CR led to overexpression.
Negative regulatory receptors of the IL-1 family.
Review
Mantovani et al., Rozzano, Italy. In Semin Immunol, 2014
In this review, the negative regulation mediated by decoy receptors are presented and include IL-1R2 and IL-IL-18BP as well as atypical receptors, which include TIR8/SIGIRR, IL-1RAcPb, TIGIRR-1 and IL-1RAPL.
The interleukin-1 family: back to the future.
Review
Impact
Mantovani et al., Rozzano, Italy. In Immunity, 2014
Members of the IL-1 Receptor (IL-1R) family include six receptor chains forming four signaling receptor complexes, two decoy receptors (IL-1R2, IL-18BP), and two negative regulators (TIR8 or SIGIRR, IL-1RAcPb).
[Negative regulation of Toll-like receptor signalling].
Review
Choroszyńska et al., Lublin, Poland. In Postepy Hig Med Dosw (online), 2012
They include soluble receptors (sTLR), transmembrane proteins (ST2, SIGIRR, RP105, TRAIL-R) and intracellular inhibitors (SOCS-1, SOCS-3, sMyD88, TOLLIP, IRAK-M, SARM, A20, β-arrestin, CYLD, SHP).
Common polymorphisms in the PKP3-SIGIRR-TMEM16J gene region are associated with susceptibility to tuberculosis.
GeneRIF
Hawn et al., Seattle, United States. In J Infect Dis, 2012
These results demonstrate a strong association of single-nucleotide polymorphisms in the PKP3-SIGIRR-TMEM16J gene region and tuberculosis in discovery and validation cohorts.
Role of Toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/Toll-like receptor signaling, in resistance to acute Pseudomonas aeruginosa lung infection.
GeneRIF
Garlanda et al., Rozzano, Italy. In Infect Immun, 2012
TIR8 has a nonredundant effect in modulating the inflammation caused by Pseudomonas aeruginosa, in particular, by negatively regulating IL-1RI signaling, which plays a major role in the pathogenesis of bacterial pneumonia.
Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models.
GeneRIF
Muzio et al., Milano, Italy. In Blood, 2011
in the absence of TIR8 the appearance of monoclonal B-cell expansions is accelerated and mouse life span is shortened in chronic lymphocytic leukemia
Interleukin-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice.
GeneRIF
Lynch et al., Dublin, Ireland. In J Neurosci, 2011
These findings highlight the functional role of SIGIRR in regulating inflammatory-mediated synaptic and cognitive decline
Toll-like receptor signaling and SIGIRR in renal fibrosis upon unilateral ureteral obstruction.
GeneRIF
Anders et al., München, Germany. In Plos One, 2010
Data argue against a significant role of SIGIRR in renal fibrosis.
The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation.
Impact
GeneRIF
Li et al., Cleveland, United States. In Immunity, 2010
Our results demonstrate an important mechanism by which SIGIRR controls Th17 cell expansion and effector function through the IL-1-induced mTOR signaling pathway.
The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis.
Impact
GeneRIF
Li et al., Cleveland, United States. In Immunity, 2007
Theses results indicate that epithelium-derived SIGIRR is critical in controlling the homeostasis and innate immune responses of the colon to enteric microflora.
SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling.
Impact
Li et al., Cleveland, United States. In Nat Immunol, 2003
These receptors alter gene expression, mainly through the activation of nuclear factor-kappaB and activating protein 1. SIGIRR (single immunoglobulin IL-1R-related molecule), a member of this family that does not activate these factors, instead negatively modulates immune responses.
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