Sialyltransferase inhibition and recent advances.
Harbin, China. In Biochim Biophys Acta, Jan 2016
Elevated sialyltransferase activity leads to overexpression of cell surface sialic acids and contributes to many disease developments, such as cancer and inflammation.
Sialylation: an Avenue to Target Cancer Cells.
Ahmadābād, India. In Pathol Oncol Res, Jan 2016
The alterations in sialylation is accompanied by changes in sialic acid, sialidase activity, sialyltransferase (ST) activity or sialoproteins.
Genes that mediate breast cancer metastasis to the brain.
New York City, United States. In Nature, 2009
Gene expression analysis of these cells and of clinical samples, coupled with functional analysis, identified the cyclooxygenase COX2 (also known as PTGS2), the epidermal growth factor receptor (EGFR) ligand HBEGF, and the alpha2,6-sialyltransferase ST6GALNAC5 as mediators of cancer cell passage through the blood-brain barrier.