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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Sialic acid binding Ig-like lectin 1, sialoadhesin

Sialoadhesin, Siglec-1, CD169, S-n
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, V1a, CD45, CD163
Papers using Sialoadhesin antibodies
HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells.
Supplier
Speck Roberto F., In PLoS ONE, 2006
... PE-conjugated mouse anti-human Siglec-1 used for the FACS analysis of MDM was purchased from Santa Cruz Biotechnology (Santa Cruz, CA) or ...
Papers on Sialoadhesin
Too much of a good thing: Sustained type 1 interferon signaling limits humoral responses to secondary viral infection.
New
Teijaro, Los Angeles, United States. In Eur J Immunol, Feb 2016
46: XXX-XXXX] identify that IFN-I signaling promotes an immune suppressive state during persistent lymphocytic choriomeningitis virus (LCMV) infection by inhibiting enforced virus replication in CD169(+) macrophages.
Sialoadhesin promotes neuroinflammation-related disease progression in two mouse models of CLN disease.
New
Martini et al., Würzburg, Germany. In Glia, Feb 2016
We now investigated the role of the inflammation-related cell adhesion molecule sialoadhesin (Sn) in Ppt1(-/-) and Cln3(-/-) mice, a model of the most frequent form, CLN3 disease.
Lipid-Mediated Targeting with Membrane-Wrapped Nanoparticles in the Presence of Corona Formation.
New
Reinhard et al., Boston, United States. In Acs Nano, Feb 2016
UNASSIGNED: Membrane-wrapped nanoparticles represent a versatile platform for utilizing specific lipid-receptor interactions, such as siallyllactose-mediated binding of the ganglioside GM3 to Siglec1 (CD169), for targeting purposes.
[Relationship between macrophages and erythropoiesis].
Review
New
Zhu et al., Tianjin, China. In Zhongguo Dang Dai Er Ke Za Zhi, Jan 2016
A recent mouse study has demonstrated that the phenotype of macrophages in erythroblastic islands is CD169(+) VCAM-1(+) ER-HR3(+) CD11b(+) F4/80(+) Ly-6G(+).
Immunotherapy against metastatic melanoma with human iPS cell-derived myeloid cell lines producing type I interferons.
New
Ihn et al., Kumamoto, Japan. In Cancer Immunol Res, Jan 2016
The iPS-ML-IFNs increased the expression of CD169, a marker of M1 macrophages that can activate antitumor immunity.
The CD169 sialoadhesin molecule mediates cytotoxic T cell responses to tumour apoptotic vesicles.
New
McLellan et al., Dunedin, New Zealand. In Immunol Cell Biol, Jan 2016
Extracellular vesicles express membrane-bound sialic acids, which enable their capture by CD169 (sialoadhesin; Siglec-1) expressing macrophages in lymph node and spleen.
Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.
New
Impact
Mothes et al., New Haven, United States. In Science, Nov 2015
CD169/Siglec-1, an I-type lectin that recognizes gangliosides, captures the virus.
PRRS virus receptors and their role for pathogenesis.
Review
New
Yoo et al., Urbana, United States. In Vet Microbiol, Jul 2015
At least six cellular molecules have been described so far as putative receptors for PRRSV, and they include heparan sulfate, vimentin, CD151, sialoadhesin (CD169; siglec-1), dendritic cell-specific intercellular adhesion melecule-3-grabbing non-integrin (DC-SIGN; CD209), and CD163 (SRCR, cysteine-rich scavenger receptor).
T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses.
New
Impact
Phan et al., Australia. In Immunity, May 2015
Following collapse of the GC, memory T cells persisted in the outer follicle where they scanned CD169(+) subcapsular sinus macrophages.
CD169-dependent cell-associated HIV-1 transmission: a driver of virus dissemination.
Review
Akiyama et al., Boston, United States. In J Infect Dis, 2015
We will evaluate the role of CD169 as a DC-associated HIV-1 attachment factor, investigate the molecular mechanisms by which HIV-1 particles are transferred from DCs to CD4(+) T cells across virological synapses, and provide arguments for inclusion of molecules in microbicides that can effectively target HIV-1 attachment to DCs and DC-mediated virus transfer.
Much More than M1 and M2 Macrophages, There are also CD169(+) and TCR(+) Macrophages.
Review
Garcia et al., Genève, Switzerland. In Front Immunol, 2014
Thus, we also review three other categories of macrophages: tumor-associated macrophages, CD169(+) macrophages, and the recently named TCR(+) macrophages.
Cognitive consequences of a sustained monocyte type 1 IFN response in HIV-1 infection.
Review
Pulliam, San Francisco, United States. In Curr Hiv Res, 2013
An IFN "alarm" signature, defined as monocyte activation with overexpression of the type1 IFN genes IFI27 and CD169, would be useful for identifying a subset of subjects with HIV-1 infection that could progress to a number of pathologies associated with immune activation including cognitive dysfunction.
CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress.
Impact
Frenette et al., New York City, United States. In Nat Med, 2013
We found that specific depletion of CD169(+) macrophages markedly reduced the number of erythroblasts in the bone marrow but did not result in overt anemia under homeostatic conditions, probably because of concomitant alterations in red blood cell clearance.
Sialoadhesin promotes rapid proinflammatory and type I IFN responses to a sialylated pathogen, Campylobacter jejuni.
GeneRIF
Crocker et al., Dundee, United Kingdom. In J Immunol, 2012
Sn is a potentially important pathogen recognition molecule for systemically introduced sialylated bacteria and is required for rapid production of proinflammatory and type I interferon (IFN) responses.
Impaired butyrate oxidation in ulcerative colitis is due to decreased butyrate uptake and a defect in the oxidation pathway.
GeneRIF
Verbeke et al., Leuven, Belgium. In Inflamm Bowel Dis, 2012
Reduced ACSM3 is associated with impaired butyrate oxidation in ulcerative colitis.
Increased monocyte expression of sialoadhesin during acute cellular rejection and other enteritides after intestine transplantation in children.
GeneRIF
Sindhi et al., Pittsburgh, United States. In Transplantation, 2012
Monocytes overexpress sialoadhesin nonspecifically during intestinal transplant rejection and systemic or enteritic inflammatory states.
Subcapsular sinus macrophage fragmentation and CD169+ bleb acquisition by closely associated IL-17-committed innate-like lymphocytes.
GeneRIF
Cyster et al., San Francisco, United States. In Plos One, 2011
The CD169 bleb(+) lymphocytes are enriched for IL-17 committed IL-7Ralpha(hi)CCR6(+) T cells and natural killer cells.
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.
GeneRIF
Frenette et al., New York City, United States. In J Exp Med, 2011
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.
CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens.
Impact
GeneRIF
Tanaka et al., Yokohama, Japan. In Immunity, 2011
CD169+ macrophage-depleted mice fail to crossprime tumor-specific CD8 T cells
Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus.
Impact
von Andrian et al., Boston, United States. In Nature, 2010
Recent work has shown that CD11b(+)CD169(+) macrophages, which populate the subcapsular sinus (SCS) of LNs, are critical for the clearance of viruses from the lymph and for initiating antiviral humoral immune responses.
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