SIAH proteins: critical roles in leukemogenesis.
Jena, Germany. In Leukemia, 2013
Here, we summarize functions of SIAH ubiquitin-ligases in leukemias, how they select leukemia-relevant substrates for proteasomal degradation, and how the expression and activity of SIAH1 and SIAH2 can be modulated in vivo.
Sprouty proteins: modified modulators, matchmakers or missing links?
Singapore, Singapore. In J Endocrinol, 2009
Significantly, two ubiquitin E3 ligases also bind to the N-terminus of Sprouty: c-Cbl binds with high affinity to the TKB binding motif and SIAH2 binds constitutively to a different site; both proteins are able to direct the ubiquitination of Sprouty proteins and its destruction.