From Mallory to Mallory-Denk bodies: What, how and why?
In The Journal of Cell Biology, 2006
... NDPK-A (NME1), NDPK-B (NME2), PSMC6, GAPDH (6C5), CYP3A1, FAH, PDIA4 (ERp72), lamin B1, PRDX6, and Siah1 (Abcam); GSTM1, CBR3, CA3, and ...
Nitric Oxide-GAPDH Transcriptional Signaling Mediates Behavioral Actions of Cocaine.
Baltimore, United States. In Cns Neurol Disord Drug Targets, 2014
We describe a signaling system wherein lower behavioral stimulant doses of cocaine, as well as higher neurotoxic doses, activate a cascade wherein nitric oxide nitrosylates glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to generate a complex with the ubiquitin-E3-ligase Siah1 which translocates to the nucleus.
SIAH proteins: critical roles in leukemogenesis.
Jena, Germany. In Leukemia, 2013
Here, we summarize functions of SIAH ubiquitin-ligases in leukemias, how they select leukemia-relevant substrates for proteasomal degradation, and how the expression and activity of SIAH1 and SIAH2 can be modulated in vivo.
Lessons from tumor reversion for cancer treatment.
Cachan, France. In Curr Opin Oncol, 2013
Differential gene-expression profiling showed that at least 300 genes are implicated in this reversion process such as SIAH-1, PS1, TSAP6, and, most importantly, translationally controlled tumor protein (TPT1/TCTP).