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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

SNF2 histone linker PHD RING helicase

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008] (from NCBI)
Papers on SHPRH
SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis.
Cimprich et al., Stanford, United States. In Mol Cell, 2011
HLTF and SHPRH suppress mutagenesis in a damage-specific manner, preventing mutations induced by UV rays and methyl methanesulfonate.
Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.
Myung et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2008
HLTF and SHPRH are functional homologues of yeast Rad5 that cooperatively mediate PCNA polyubiquitination and maintain genomic stability.
Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination.
Myung et al., Bethesda, United States. In J Cell Biol, 2007
We report that a putative tumor suppressor gene, SHPRH, is a human orthologue of yeast RAD5.The yRad5/SHPRH-dependent pathway is a conserved and fundamental DNA repair mechanism that protects the genome from genotoxic stress.
Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen.
Haracska et al., Szeged, Hungary. In Proc Natl Acad Sci U S A, 2006
SHPRH function is an important deterrent to mutagenesis and carcinogenesis in humans
Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region.
Trent et al., Bethesda, United States. In Genomics, 2003
SHPRH maps to 6q24 and is a possible candidate for the tumor suppressor gene reported from that region.
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