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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

SNF2 histone linker PHD RING helicase

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: RAD18, HLTF, PCNA, Ubiquitin, FUS
Papers on SHPRH
Analysis of SHPRH functions in DNA repair and immunoglobulin diversification.
Jungnickel et al., Jena, Germany. In Dna Repair (amst), 2014
An error-free bypass pathway may be initiated via K63-linked PCNA polyubiquitination by Ubc13/Mms2 and the E3 ligase Rad5 in yeast, or HLTF/SHPRH in vertebrates.
Rad5 plays a major role in the cellular response to DNA damage during chromosome replication.
Tercero et al., Madrid, Spain. In Cell Rep, 2014
Here, we show that Rad5(HLTF/SHPRH), which mediates the error-free branch, has a major role in the response to DNA damage caused by methyl methanesulfonate (MMS) during chromosome replication, whereas translesion synthesis polymerases make only a minor contribution.
DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis.
Cimprich et al., Santa Cruz de Tenerife, Spain. In J Cell Biol, 2014
The ubiquitinated form of Rad18 does not interact with SNF2 histone linker plant homeodomain RING helicase (SHPRH) or helicase-like transcription factor, two downstream E3 ligases needed to carry out error-free bypass of DNA lesions.
PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells.
Livneh et al., Israel. In Plos Genet, 2011
In contrast, cells lacking the Rad5-homologs Shprh and Hltf, which polyubiquitinate PCNA, exhibited normal TLS.
SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis.
Cimprich et al., Stanford, United States. In Mol Cell, 2011
HLTF and SHPRH suppress mutagenesis in a damage-specific manner, preventing mutations induced by UV rays and methyl methanesulfonate.
DNA damage discrimination at stalled replication forks by the Rad5 homologs HLTF and SHPRH.
D'Andrea et al., Boston, United States. In Mol Cell, 2011
In this issue of Molecular Cell, Lin et al. (2011) describe how HLTF and SHPRH, the human homologs of yeast Rad5, can discriminate between MMS-induced versus UV-induced DNA damage.
HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase.
Jacobs et al., Amsterdam, Netherlands. In Dna Repair (amst), 2011
Two Rad5 orthologs, HLTF and SHPRH have been identified as alternative E3 ligases generating PCNA-Ub(n) in mammals.
[Study on invasion and metastasis-associated genes of lung cancer related with NM23-H1 gene].
Li et al., Chengdu, China. In Sichuan Da Xue Xue Bao Yi Xue Ban, 2010
After real-time quantitative PCR evaluation, we found that the mRNA of 8 genes including PSMA7, SBDS, ODC1, YARS, CSDA, PTP4A1, SHPRH and TOMM7 was up-regulated in the cell line of L9981 after transfected with NM23-H1 gene, whereas the mRNA of PKM2 and GMNN was down-regulated.
Role of yeast Rad5 and its human orthologs, HLTF and SHPRH in DNA damage tolerance.
Haracska et al., Szeged, Hungary. In Dna Repair (amst), 2010
Here we summarize findings published in recent years regarding the role of Rad5 in promoting error-free replication of damaged DNA, and we also discuss results obtained with its human orthologs, HLTF and SHPRH.
Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.
Myung et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2008
HLTF and SHPRH are functional homologues of yeast Rad5 that cooperatively mediate PCNA polyubiquitination and maintain genomic stability.
hMMS2 serves a redundant role in human PCNA polyubiquitination.
Gray et al., Ottawa, Canada. In Bmc Mol Biol, 2007
Recently, it was shown that PCNA polyubiquitination is conserved in human cells and that this modification is dependent on RAD18, UBC13 and SHPRH.
Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination.
Myung et al., Bethesda, United States. In J Cell Biol, 2007
We report that a putative tumor suppressor gene, SHPRH, is a human orthologue of yeast RAD5.The yRad5/SHPRH-dependent pathway is a conserved and fundamental DNA repair mechanism that protects the genome from genotoxic stress.
Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen.
Haracska et al., Szeged, Hungary. In Proc Natl Acad Sci U S A, 2006
SHPRH function is an important deterrent to mutagenesis and carcinogenesis in humans
Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region.
Trent et al., Bethesda, United States. In Genomics, 2003
SHPRH maps to 6q24 and is a possible candidate for the tumor suppressor gene reported from that region.
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