Quinalizarin enhances radiosensitivity of nasopharyngeal carcinoma cells partially by suppressing SHP-1 expression.
Zhanjiang, China. In Int J Oncol, Feb 2016
Cell viability, survival, DNA double-strand breaks (DSB), apoptosis, cell cycle distribution, expression of SHP-1 and other related proteins were detected with MTT assay, colony formation assay, immunofluorescent assay, flow cytometry and western blot analysis, respectively.
Inhibitory leukocyte immunoglobulin-like receptors: Immune checkpoint proteins and tumor sustaining factors.
Dallas, United States. In Cell Cycle, Feb 2016
Inhibitory leukocyte immunoglobulin-like receptors (LILRBs 1-5) transduce signals via intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein tyrosine phosphatase non-receptor type 6 (PTPN6 or SHP-1), protein tyrosine phosphatase non-receptor type 11 (PTPN11 or SHP-2), or Src homology 2 domain-containing inositol phosphatase (SHIP), leading to negative regulation of immune cell activation.
Inhibitory leukocyte immunoglobulin-like receptors in cancer development.
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Shanghai, China. In Sci China Life Sci, Dec 2015
Inhibitory leukocyte immunoglobulin-like receptors (LILRB1-5) signal through immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their intracellular domains and recruit phosphatases protein tyrosine phosphatase, non-receptor type 6 (PTPN6, SHP-1), protein tyrosine phosphatase, non-receptor type 6 (PTPN6, SHP-2), or Src homology 2 domain containing inositol phosphatase (SHIP) to negatively regulate immune cell activation.
Negative Regulation of Mast Cell Signaling and Function by the Adaptor LAB/NTAL
In The Journal of Experimental Medicine, 1995
... PLCγ1, PLCγ2, ERK 1, phospho-ERK (specific for phosphorylated Tyr 204), Grb2, SH2-containing protein tyrosine phosphatase (SHP)-2, and horseradish peroxidase (HRP)–conjugated donkey anti–goat IgG, goat anti–mouse IgG, and goat anti–rabbit IgG were obtained from Santa Cruz Biotechnology, Inc ...