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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Short stature homeobox 2

Shox2, SHOT, OG12X, OG-12
This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009] (from NCBI)
Papers on Shox2
DNA methylation of the homeobox genes PITX2 and SHOX2 predicts outcome in non-small-cell lung cancer patients.
GeneRIF
Soltermann et al., Bonn, Germany. In Diagn Mol Pathol, 2012
DNA methylation of PITX2 and SHOX2 is an independent prognostic biomarker for disease progression in non-small-cell lung cancer patients.
Performance evaluation of the DNA methylation biomarker SHOX2 for the aid in diagnosis of lung cancer based on the analysis of bronchial aspirates.
GeneRIF
Field et al., Berlin, Germany. In Int J Oncol, 2012
A CE marked in vitro diagnostic test kit to quantify SHOX2 DNA methylation in bronchial aspirates was developed and characterized.
Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touch.
GeneRIF
Ernfors et al., Stockholm, Sweden. In Eur J Neurosci, 2011
These results show that Shox2 is required for specification of a subclass of TrkB(+) sensory neurons which convey the sensation of discriminative touch arising from stimuli of the skin.
SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer in plasma.
GeneRIF
Dietrich et al., Mainz, Germany. In J Thorac Oncol, 2011
SHOX2 DNA methylation is associated with lung cancer.
Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons.
GeneRIF
Wang et al., Durham, United States. In J Neurosci, 2011
our findings identify Shox2 as an essential but not sufficient component of the transcription programs required in neural progenitor cells for the proper specification of subsets of TrkB-expressing touch/mechanosensory neurons.
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