Discovery of variant infectious salmon anaemia virus (ISAV) of European genotype in British Columbia, Canada.
Charlottetown, Canada. In Virol J, Dec 2015
METHODS: In this study, we tested 1,106 fish tissue samples collected from (i) market-bought farmed salmonids and (ii) wild salmon from throughout British Columbia (BC), Canada, for ISAV using real time RT-qPCR targeting segment 8 and/or conventional RT-PCR with segment 8 primers and segment 6 HPR primers, and by virus isolation attempts using Salmon head kidney (SHK-1 and ASK-2) cell line monolayers.
Computational studies of marine toxins targeting ion channels.
Sydney, Australia. In Mar Drugs, 2013
Detailed examples from the potassium channel toxins-ShK from sea anemone and κ-conotoxin PVIIA-are provided to demonstrate capabilities of the computational methods to give accurate descriptions of the channel-toxin complexes and the energetics of their binding.
Polarizing macrophages through reprogramming of glucose metabolism.
Montréal, Canada. In Cell Metab, 2012
(2012) show that the sedoheptulose kinase CARKL is required for metabolic reprogramming in activated macrophages and provide evidence that changes in glucose metabolism and the pentose phosphate pathway (PPP) influences macrophage polarization.