GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 18 Mar 2014.
Inositol polyphosphate phosphatase-like 1
SHIP2, INPPL1
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009] (from
NCBI)
Sponsored links
Top mentioned proteins:
Insulin, SHIP, Akt, Src, PTEN
Papers using
SHIP2
antibodies
SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis
Supplier
In The Journal of Cell Biology, 2006
Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate
Supplier
In The Journal of Cell Biology, 2006
... HuSH 29-mer SHIP2-specific shRNA and control shRNA constructs were purchased from OriGene Technologies.
Papers on
SHIP2
Early Gene Expression Changes in Skeletal Muscle from SOD1(G93A) Amyotrophic Lateral Sclerosis Animal Model.
New
São Paulo, Brazil. In Cell Mol Neurobiol, 30 Apr 2014
A customized cDNA microarray platform containing 326 genes of Wnt/PI3 K and EMT was used and results revealed eight up-regulated (Loxl2, Pik4ca, Fzd9, Cul1, Ctnnd1, Snf1lk, Prkx, Dner) and nine down-regulated (Pik3c2a, Ripk4, Id2, C1qdc1, Eif2ak2, Rac3, Cds1, Inppl1, Tbl1x) genes at 40 days, and also one up-regulated (Pik3ca) and five down-regulated (Cd44, Eef2 k, Fzd2, Crebbp, Piki3r1) genes at 80 days.
Phosphorylated SHIP2 on Y1135 localizes at focal adhesions and at the mitotic spindle in cancer cell lines.
New
Brussels, Belgium. In Cell Signal, 19 Mar 2014
UNLABELLED: The SH2 containing inositol 5-phosphatase SHIP2 is a member of the mammalian phosphoinositide polyphosphate 5-phosphatase family.
SHIP2 signaling in normal and pathological situations: Its impact on cell proliferation.
Review
New
Brussels, Belgium. In Adv Biol Regul, Jan 2014
The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to this family of enzymes that dephosphorylate the 5 position of PI(3,4,5)P3 to produce PI(3,4)P2.
SHIP2: a "NEW" insulin pathway target for ageing research.
New
United States. In Rejuvenation Res, Jan 2014
Since some single nucleotide polymorphisms (SNP) of the gene encoding SHIP2, were significantly associated in T2DM patients with metabolic syndrome and some related conditions, we decided to conduct a case-control study on this gene, analyzing AD and T2DM subjects as cases and young, old and centenarians as controls.
Discovery and Development of Small Molecule SHIP Phosphatase Modulators.
New
Syracuse, United States. In Med Res Rev, Jan 2014
In addition, a comprehensive survey of small molecule modulators of SHIP1 and SHIP2 is provided, with a focus on the structure, potency, selectivity, and solubility properties of these compounds.
Molecular simulations of a dynamic protein complex: role of salt-bridges and polar interactions in configurational transitions.
New
Cleveland, United States. In Biophys J, Dec 2013
We have previously characterized one such system: the EphA2:SHIP2 SAM-SAM heterodimer by solution NMR.
SHIP2 signalling at the plasma membrane, in the nucleus and at focal contacts.
Review
Brussels, Belgium. In Adv Biol Regul, 2013
The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to this family of enzymes very much involved in physiopathology and development.
Global phosphotyrosine proteomics identifies PKCδ as a marker of responsiveness to Src inhibition in colorectal cancer.
Nashville, United States. In Plos One, 2012
Major dasatinib-responsive pY sites in xenograft tumors included sites on delta-type protein kinase C (PKCδ), CUB-domain-containing protein 1 (CDCP1), Type-II SH2-domain-containing inositol 5-phosphatase (SHIP2), and receptor protein-tyrosine phosphatase alpha (RPTPα).
Role of Inositol Poly-Phosphatases and Their Targets in T Cell Biology.
Review
Syracuse, United States. In Front Immunol, 2012
Consequently, the 5'- and 3'-inositol poly-phosphatases SHIP1, SHIP2, and phosphatase and tensin homolog capable of targeting PI(3,4,5)P3 are potential genetic determinants of T cell effector functions in vivo.
The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration.
GeneRIF
Nagoya, Japan. In Mol Biol Cell, 2012
RhoA associates with SHIP2 to regulate cell polarization and migration.
Role of inhibitory BCR co-receptors in immunity.
Review
Tokyo, Japan. In Infect Disord Drug Targets, 2012
When phosphorylated, ITIMs in these molecules recruit and activate phosphatases such as SH2 domain-containing protein tyrosine phosphatase 1 (SHP-1), SHP-2, SH2 domain- containing inositol 5-phosphatase 1 (SHIP1) and SHIP2 depending on receptors.
Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).
GeneRIF
Kōbe, Japan. In J Biol Chem, 2012
Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).
NMR structure of a heterodimeric SAM:SAM complex: characterization and manipulation of EphA2 binding reveal new cellular functions of SHIP2.
GeneRIF
Cleveland, United States. In Structure, 2012
SHIP2 suppresses ligand-induced activation of EphA2 and promotes receptor coordinated chemotactic cell migration.
Inositol polyphosphate phosphatases in human disease.
Review
Australia. In Curr Top Microbiol Immunol, 2011
Additionally, polymorphisms in the 5-phosphatase SHIP2 confer diabetes susceptibility in specific populations, whereas reduced protein expression of SHIP1 is reported in several human leukaemias.
Prognostic value of elevated SHIP2 expression in laryngeal squamous cell carcinoma.
GeneRIF
Changsha, China. In Arch Med Res, 2011
results support the hypothesis that SHIP2 may play a critical role in the initiation and progression of LSCC and may serve as both a prognostic marker and a potential therapeutic target in patients with LSCC
Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin.
GeneRIF
Ann Arbor, United States. In Plos One, 2010
Nephrin ligation resulted in abnormal morphology of actin tails in human podocytes when Ship2, Filamin or Lamellipodin were individually knocked down.
Lipid phosphatases as drug discovery targets for type 2 diabetes.
Review
Impact
Indianapolis, United States. In Nat Rev Drug Discov, 2006
Here we review the evidence that lipid phosphatases, specifically PTEN and SHIP2, attenuate this important insulin signalling pathway.
Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity.
Impact
GeneRIF
New York City, United States. In Nat Med, 2005
Results suggest that inhibition of SHIP2 would be useful in the effort to ameliorate diet-induced obesity, but call into question a dominant role of SHIP2 in modulating glucose homeostasis.
LPS-induced upregulation of SHIP is essential for endotoxin tolerance.
Impact
Vancouver, Canada. In Immunity, 2004
Moreover, an initial LPS treatment of wild-type BMmphis or BMMCs increases the level of SHIP, but not SHIP2 or PTEN, and this increase is critical for the hyporesponsiveness to subsequent LPS stimulation.
The lipid phosphatase SHIP2 controls insulin sensitivity.
Impact
Belgium. In Nature, 2001
In vitro studies have shown that SHIP2, in response to stimulation by numerous growth factors and insulin, is closely linked to signalling events mediated by both phosphoinositide-3-OH kinase and Ras/mitogen-activated protein kinase.
