GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Aug 2016.
Inositol polyphosphate phosphatase-like 1
SHIP2, INPPL1
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009] (from
NCBI)
Sponsored links
Top mentioned proteins:
Insulin, SHIP, Akt, Src, PTEN
Papers using
SHIP2
antibodies
SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis
Supplier
In The Journal of Cell Biology, 2006
Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate
Supplier
In The Journal of Cell Biology, 2006
... HuSH 29-mer SHIP2-specific shRNA and control shRNA constructs were purchased from OriGene Technologies.
Papers on
SHIP2
Angiotensin II down-regulates nephrin-Akt signaling and induces podocyte injury: roleof c-Abl.
New
Wuhan, China. In Mol Biol Cell, Feb 2016
Moreover, Ang II promoted c-Abl phosphorylation and interaction between c-Abl and SH2 domain-containing 5'-inositol phosphatase 2 (SHIP2).
SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells.
New
Tehrān, Iran. In Free Radic Biol Med, Dec 2015
Hepatic de-novo lipogenesis and production of triglyceride rich very low density lipoprotein (VLDL) is increased in the state of insulin resistance, however, the role of a negative regulator of the insulin signaling pathway, the SH2 domain-containing inositol 5-phosphatase (SHIP2) in this process, remains unknown.
Association between waist circumference and gray matter volume in 2344 individuals from two adult community-based samples.
New
Greifswald, Germany. In Neuroimage, Dec 2015
We analyzed the putative association between abdominal obesity (measured in waist circumference) and gray matter volume (Study of Health in Pomerania: SHIP-2, N=758) adjusted for age and gender by applying volumetric analysis and voxel-based morphometry (VBM) with VBM8 to brain magnetic resonance (MR) imaging.
PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena.
New
Utrecht, Netherlands. In Mol Biol Cell, Dec 2015
Mena also interacts with the 5' inositol phosphatase SHIP2, which is important for the recruitment of the Mena-PTP1B complex to the EGFR.
Serum Thyrotropin Concentrations Are Not Associated with the Ankle-Brachial Index: Results from Three Population-Based Studies.
New
Greifswald, Germany. In Eur Thyroid J, Sep 2015
METHODS: We used data from 5,818 individuals from three cross-sectional population-based studies conducted in Northeast (SHIP-2 and SHIP-TREND) and Central Germany (CARLA).
Endophilin marks and controls a clathrin-independent endocytic pathway.
New
Impact
Cambridge, United Kingdom. In Nature, Feb 2015
This pathway is prominent at the leading edges of cells where phosphatidylinositol-3,4-bisphosphate-produced by the dephosphorylation of phosphatidylinositol-3,4,5-triphosphate by SHIP1 and SHIP2-recruits lamellipodin, which in turn engages endophilin.
Breast cancer stem cells, EMT and therapeutic targets.
Review
India. In Biochem Biophys Res Commun, 2014
This review also lists the miRNA interactions identified in BCSCs and discusses on some newly identified targets in the BCSC regulatory pathways like SHIP2, nicastrin, Pin 1, IGF-1R, pro-inflammatory cytokines and syndecan which can be targeted for therapeutic achievements.
Discovery and development of small molecule SHIP phosphatase modulators.
Review
Syracuse, United States. In Med Res Rev, 2014
In addition, a comprehensive survey of small molecule modulators of SHIP1 and SHIP2 is provided, with a focus on the structure, potency, selectivity, and solubility properties of these compounds.
SHIP2 signaling in normal and pathological situations: Its impact on cell proliferation.
Review
Brussels, Belgium. In Adv Biol Regul, 2014
The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to this family of enzymes that dephosphorylate the 5 position of PI(3,4,5)P3 to produce PI(3,4)P2.
Role of inositol poly-phosphatases and their targets in T cell biology.
Review
Syracuse, United States. In Front Immunol, 2012
Consequently, the 5'- and 3'-inositol poly-phosphatases SHIP1, SHIP2, and phosphatase and tensin homolog capable of targeting PI(3,4,5)P3 are potential genetic determinants of T cell effector functions in vivo.
The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration.
GeneRIF
Nagoya, Japan. In Mol Biol Cell, 2012
RhoA associates with SHIP2 to regulate cell polarization and migration.
Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).
GeneRIF
Kōbe, Japan. In J Biol Chem, 2012
Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).
NMR structure of a heterodimeric SAM:SAM complex: characterization and manipulation of EphA2 binding reveal new cellular functions of SHIP2.
GeneRIF
Cleveland, United States. In Structure, 2012
SHIP2 suppresses ligand-induced activation of EphA2 and promotes receptor coordinated chemotactic cell migration.
Inositol polyphosphate phosphatases in human disease.
Review
Australia. In Curr Top Microbiol Immunol, 2011
Additionally, polymorphisms in the 5-phosphatase SHIP2 confer diabetes susceptibility in specific populations, whereas reduced protein expression of SHIP1 is reported in several human leukaemias.
Prognostic value of elevated SHIP2 expression in laryngeal squamous cell carcinoma.
GeneRIF
Changsha, China. In Arch Med Res, 2011
results support the hypothesis that SHIP2 may play a critical role in the initiation and progression of LSCC and may serve as both a prognostic marker and a potential therapeutic target in patients with LSCC
Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin.
GeneRIF
Ann Arbor, United States. In Plos One, 2010
Nephrin ligation resulted in abnormal morphology of actin tails in human podocytes when Ship2, Filamin or Lamellipodin were individually knocked down.
Lipid phosphatases as drug discovery targets for type 2 diabetes.
Review
Impact
Indianapolis, United States. In Nat Rev Drug Discov, 2006
Here we review the evidence that lipid phosphatases, specifically PTEN and SHIP2, attenuate this important insulin signalling pathway.
Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity.
Impact
GeneRIF
New York City, United States. In Nat Med, 2005
Results suggest that inhibition of SHIP2 would be useful in the effort to ameliorate diet-induced obesity, but call into question a dominant role of SHIP2 in modulating glucose homeostasis.
LPS-induced upregulation of SHIP is essential for endotoxin tolerance.
Impact
Vancouver, Canada. In Immunity, 2004
Moreover, an initial LPS treatment of wild-type BMmphis or BMMCs increases the level of SHIP, but not SHIP2 or PTEN, and this increase is critical for the hyporesponsiveness to subsequent LPS stimulation.
The lipid phosphatase SHIP2 controls insulin sensitivity.
Impact
Belgium. In Nature, 2001
In vitro studies have shown that SHIP2, in response to stimulation by numerous growth factors and insulin, is closely linked to signalling events mediated by both phosphoinositide-3-OH kinase and Ras/mitogen-activated protein kinase.
