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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 May 2015.

Inositol polyphosphate phosphatase-like 1

SHIP2, INPPL1
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: Insulin, SHIP, Akt, Src, PTEN
Papers using SHIP2 antibodies
SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis
Supplier
Itoh Toshiki et al., In The Journal of Cell Biology, 2006
... Mouse anti-HA monoclonal antibody and rabbit anti-Myc and anti-SHIP2 polyclonal antibodies were purchased from Cell Signaling Technology ...
Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate
Supplier
De Camilli Pietro et al., In The Journal of Cell Biology, 2006
... HuSH 29-mer SHIP2-specific shRNA and control shRNA constructs were purchased from OriGene Technologies.
Papers on SHIP2
Identification of SHIP-1 and SHIP-2 homologs in channel catfish, Ictalurus punctatus.
New
Wilson et al., Jackson, United States. In Dev Comp Immunol, 31 Jul 2015
SHIP-1 and SHIP-2 homologs were identified in channel catfish, Ictalurus punctatus, based on sequence homology to murine and human SHIP sequences.
Positive Association Between Adipose Tissue and Bone Stiffness.
New
Hannemann et al., Greifswald, Germany. In Calcif Tissue Int, 01 Jun 2015
The study involved 2685 German adults aged 20-79 years, who participated in either the second follow-up of the population-based Study of Health in Pomerania (SHIP-2) or the baseline examination of the SHIP-Trend cohort.
Endophilin marks and controls a clathrin-independent endocytic pathway.
New
Impact
McMahon et al., Cambridge, United Kingdom. In Nature, Feb 2015
This pathway is prominent at the leading edges of cells where phosphatidylinositol-3,4-bisphosphate-produced by the dephosphorylation of phosphatidylinositol-3,4,5-triphosphate by SHIP1 and SHIP2-recruits lamellipodin, which in turn engages endophilin.
Single nucleotide polymorphisms on SHIP2 is associated with Type 2 diabetes mellitus in Chinese Han population.
New
Zuo et al., Shijiazhuang, China. In Eur Rev Med Pharmacol Sci, Jan 2015
Src homology 2-containing 5'-inositol phosphatase 2 (SHIP2) is a lipid phosphatase that hydrolyzes PI3-kinase product PI(3,4,5)P3 to PI(3,4)P2, which contributes to the negative regulation of insulin signaling both in vitro and in vivo.
Breast cancer stem cells, EMT and therapeutic targets.
Review
New
Bhattacharya et al., India. In Biochem Biophys Res Commun, Nov 2014
This review also lists the miRNA interactions identified in BCSCs and discusses on some newly identified targets in the BCSC regulatory pathways like SHIP2, nicastrin, Pin 1, IGF-1R, pro-inflammatory cytokines and syndecan which can be targeted for therapeutic achievements.
Discovery and development of small molecule SHIP phosphatase modulators.
Review
New
Chisholm et al., Syracuse, United States. In Med Res Rev, Jul 2014
In addition, a comprehensive survey of small molecule modulators of SHIP1 and SHIP2 is provided, with a focus on the structure, potency, selectivity, and solubility properties of these compounds.
SHIP2 signaling in normal and pathological situations: Its impact on cell proliferation.
Review
Erneux et al., Brussels, Belgium. In Adv Biol Regul, 2014
The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to this family of enzymes that dephosphorylate the 5 position of PI(3,4,5)P3 to produce PI(3,4)P2.
High SHIP2 expression indicates poor survival in colorectal cancer.
Gu et al., Suzhou, China. In Dis Markers, 2013
SH2-containing inositol 5'-phosphatase 2 (SHIP2), which generally regulates insulin signaling, cytoskeleton remodeling, and receptor endocytosis, has been suggested to play a significant role in tumor development and progression.
Evidence for SH2 domain-containing 5'-inositol phosphatase-2 (SHIP2) contributing to a lymphatic dysfunction.
Sevick-Muraca et al., Ann Arbor, United States. In Plos One, 2013
Using near-infrared fluorescence lymphatic imaging (NIRFLI) to phenotype and next generation sequencing (NGS) for unbiased genetic discovery in a family with non-syndromic lymphatic disease, we discovered a rare, novel mutation in INPPL1 that encodes the protein SHIP2, which is a negative regulator of the PI3K pathway, to be associated with lymphatic dysfunction in the family.
Role of inositol poly-phosphatases and their targets in T cell biology.
Review
Kerr et al., Syracuse, United States. In Front Immunol, 2012
Consequently, the 5'- and 3'-inositol poly-phosphatases SHIP1, SHIP2, and phosphatase and tensin homolog capable of targeting PI(3,4,5)P3 are potential genetic determinants of T cell effector functions in vivo.
The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration.
GeneRIF
Kaibuchi et al., Nagoya, Japan. In Mol Biol Cell, 2012
RhoA associates with SHIP2 to regulate cell polarization and migration.
Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).
GeneRIF
Takenawa et al., Kōbe, Japan. In J Biol Chem, 2012
Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).
NMR structure of a heterodimeric SAM:SAM complex: characterization and manipulation of EphA2 binding reveal new cellular functions of SHIP2.
GeneRIF
Buck et al., Cleveland, United States. In Structure, 2012
SHIP2 suppresses ligand-induced activation of EphA2 and promotes receptor coordinated chemotactic cell migration.
Inositol polyphosphate phosphatases in human disease.
Review
Mitchell et al., Australia. In Curr Top Microbiol Immunol, 2011
Additionally, polymorphisms in the 5-phosphatase SHIP2 confer diabetes susceptibility in specific populations, whereas reduced protein expression of SHIP1 is reported in several human leukaemias.
Prognostic value of elevated SHIP2 expression in laryngeal squamous cell carcinoma.
GeneRIF
Tan et al., Changsha, China. In Arch Med Res, 2011
results support the hypothesis that SHIP2 may play a critical role in the initiation and progression of LSCC and may serve as both a prognostic marker and a potential therapeutic target in patients with LSCC
Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin.
GeneRIF
Garg et al., Ann Arbor, United States. In Plos One, 2010
Nephrin ligation resulted in abnormal morphology of actin tails in human podocytes when Ship2, Filamin or Lamellipodin were individually knocked down.
Lipid phosphatases as drug discovery targets for type 2 diabetes.
Review
Impact
Saltiel et al., Indianapolis, United States. In Nat Rev Drug Discov, 2006
Here we review the evidence that lipid phosphatases, specifically PTEN and SHIP2, attenuate this important insulin signalling pathway.
Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity.
Impact
GeneRIF
Glass et al., New York City, United States. In Nat Med, 2005
Results suggest that inhibition of SHIP2 would be useful in the effort to ameliorate diet-induced obesity, but call into question a dominant role of SHIP2 in modulating glucose homeostasis.
LPS-induced upregulation of SHIP is essential for endotoxin tolerance.
Impact
Krystal et al., Vancouver, Canada. In Immunity, 2004
Moreover, an initial LPS treatment of wild-type BMmphis or BMMCs increases the level of SHIP, but not SHIP2 or PTEN, and this increase is critical for the hyporesponsiveness to subsequent LPS stimulation.
The lipid phosphatase SHIP2 controls insulin sensitivity.
Impact
Schurmans et al., Belgium. In Nature, 2001
In vitro studies have shown that SHIP2, in response to stimulation by numerous growth factors and insulin, is closely linked to signalling events mediated by both phosphoinositide-3-OH kinase and Ras/mitogen-activated protein kinase.
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