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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Inositol polyphosphate-5-phosphatase, 145kDa

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Src, CAN, Akt, PI3K, SHP1
Papers using SHIP antibodies
Granulocyte macrophage colony-stimulating factor inhibits breast cancer growth and metastasis by invoking an anti-angiogenic program in tumor-educated macrophages.
Hotchin Neil A., In PLoS ONE, 2008
... Phospho-tyrosine (pY) and SHIP antibodies were from Cell Signaling Technology (Beverly, MA) ...
Discriminating gene expression profiles of memory B cell subpopulations
Cooper Max D. et al., In The Journal of Experimental Medicine, 2003
... ) Antibodies to RUNX1, RUNX2, and SHIP were obtained from Santa Cruz Biotechnology, Inc ...
Paired Activating and Inhibitory Immunoglobulin-like Receptors, MAIR-I and MAIR-II, Regulate Mast Cell and Macrophage Activation
Shibuya Akira et al., In The Journal of Experimental Medicine, 1999
... from Upstate Biotechnology; anti-Flag mAb was purchased from Sigma-Aldrich; anti–SHP-1, anti–SHP-2, and anti–SH 2 domain–containing inositol-5–phosphatase (SHIP) antibodies were purchased from Santa Cruz Biotechnology, Inc.; and rat IgE ...
Papers on SHIP
Vitamin D is associated with cardiopulmonary exercise capacity: results of two independent cohorts of healthy adults.
Friedrich et al., Greifswald, Germany. In Br J Nutr, Feb 2016
For this, 1377 participants from the Study of Health in Pomerania (SHIP-1) and 750 participants from the independent SHIP-TREND cohort were investigated.
Frequency and amplitude control of cortical oscillations by phosphoinositide waves.
Wu et al., Singapore, Singapore. In Nat Chem Biol, Feb 2016
Here, we identified two phosphoinositide phosphatases, synaptojanin 2 and SHIP1, that function in periodic traveling waves of rat basophilic leukemia (RBL) mast cells.
Inhibitory leukocyte immunoglobulin-like receptors: Immune checkpoint proteins and tumor sustaining factors.
Zhang et al., Dallas, United States. In Cell Cycle, Feb 2016
Inhibitory leukocyte immunoglobulin-like receptors (LILRBs 1-5) transduce signals via intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein tyrosine phosphatase non-receptor type 6 (PTPN6 or SHP-1), protein tyrosine phosphatase non-receptor type 11 (PTPN11 or SHP-2), or Src homology 2 domain-containing inositol phosphatase (SHIP), leading to negative regulation of immune cell activation.
SHIP represses lung inf lammation and inhibits mammary tumor metastasis in BALB/c mice.
Krystal et al., Vancouver, Canada. In Oncotarget, Jan 2016
UNASSIGNED: SH2-containing-inositol-5'-phosphatase (SHIP) is a negative regulator of the phosphatidylinositol-3-kinase pathway in hematopoietic cells and limits the development of leukemias and lymphomas.
Phosphatidylinositol (3,4) bisphosphate-specific phosphatases and effector proteins: A distinct branch of PI3K signaling.
Marshall et al., Canada. In Cell Signal, Sep 2015
Historically, the function of PI3K signaling has often been attributed to PIP3, with PI(3,4)P2 considered an inconsequential byproduct of PIP3 hydrolysis by SHIP phosphatases.
MicroRNA regulation of viral immunity, latency, and carcinogenesis of selected tumor viruses and HIV.
Ning et al., Johnson City, United States. In Rev Med Virol, Sep 2015
In this review, we summarize the potential roles and mechanisms of viral and cellular miRNAs in the host-pathogen interactions during infection with selected tumor viruses and HIV, which include (i) repressing viral replication and facilitating latency establishment by targeting viral transcripts, (ii) evading innate and adaptive immune responses via toll-like receptors, RIG-I-like receptors, T-cell receptor, and B-cell receptor pathways by targeting signaling molecules such as TRAF6, IRAK1, IKKε, and MyD88, as well as downstream targets including regulatory cytokines such as tumor necrosis factor α, interferon γ, interleukin 10, and transforming growth factor β, (iii) antagonizing intrinsic and extrinsic apoptosis pathways by targeting pro-apoptotic or anti-apoptotic gene transcripts such as the Bcl-2 family and caspase-3, (iv) modulating cell proliferation and survival through regulation of the Wnt, PI3K/Akt, Erk/MAPK, and Jak/STAT signaling pathways, as well as the signaling pathways triggered by viral oncoproteins such as Epstein-Barr Virus LMP1, by targeting Wnt-inhibiting factor 1, SHIP, pTEN, and SOCSs, and (v) regulating cell cycle progression by targeting cell cycle inhibitors such as p21/WAF1 and p27/KIP1.
Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.
Müschen et al., San Francisco, United States. In Nature, Jun 2015
Using a novel small-molecule inhibitor of INPP5D (also known as SHIP1), we demonstrated that pharmacological hyperactivation of SYK and engagement of negative B-cell selection represents a promising new strategy to overcome drug resistance in human ALL.
MicroRNAs in B-cell lymphomas: how a complex biology gets more complex.
Mraz et al., Brno, Czech Republic. In Leukemia, May 2015
We focus on miR-contribution to the regulation of important signalling pathways (such as NF-κB, PI3K/AKT and TGF-β), BCR signalling and its modulators (such as PTEN, SHIP-1, ZAP-70, GAB1 and BTK), anti- and pro-apoptotic proteins (such as BCL2, MCL1, TCL1, BIM, p53 and SIRT1) and transcription factors (such as MYC, MYB, PU.1, FOXP1 and BCL6).
Endophilin marks and controls a clathrin-independent endocytic pathway.
McMahon et al., Cambridge, United Kingdom. In Nature, Feb 2015
This pathway is prominent at the leading edges of cells where phosphatidylinositol-3,4-bisphosphate-produced by the dephosphorylation of phosphatidylinositol-3,4,5-triphosphate by SHIP1 and SHIP2-recruits lamellipodin, which in turn engages endophilin.
CRISPR/CAS9-Mediated Genome Editing of miRNA-155 Inhibits Proinflammatory Cytokine Production by RAW264.7 Cells.
Zhu et al., Beijing, China. In Biomed Res Int, 2014
While upregulating the Src homology-2 domain-containing inositol 5-phosphatase 1 (SHIP1), the miR-155 GKO line is severely impaired in producing proinflammatory cytokines but slightly increased in osteoclastogenesis upon treatment with receptor activator of nuclear factor-κB ligand (RANKL).
Systems biology of megakaryocytes.
Kaushansky et al., Seattle, United States. In Adv Exp Med Biol, 2013
Among the best studied are the signal transducers and activators of transcription (STAT) proteins; phosphoinositol-3-kinase; mitogen-activated protein kinases; the phosphatases PTEN, SHP1, SHP2, and SHIP1; and the suppressors of cytokine signaling (SOCS) proteins.
Regulation of FcεRI signaling by lipid phosphatases.
Huber et al., Aachen, Germany. In Curr Top Microbiol Immunol, 2013
In this context, the SH2-containing inositol-5'-phosphatase, SHIP1, has been demonstrated to be of particular importance.
Identification of genetic loci associated with Helicobacter pylori serologic status.
Kuipers et al., Greifswald, Germany. In Jama, 2013
pylori IgG serology in the Study of Health in Pomerania (SHIP) (recruitment, 1997-2001 [n = 3830]) as well as the Rotterdam Study (RS-I) (recruitment, 1990-1993) and RS-II (recruitment, 2000-2001 [n = 7108]) populations.
Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1.
Köhl et al., Lübeck, Germany. In Nat Med, 2012
IgG1 ICs promote the association of FcγRIIB with dectin-1, resulting in phosphorylation of Src homology 2 domain–containing inositol phosphatase (SHIP) downstream of FcγRIIB and spleen tyrosine kinase downstream of dectin-1.
A pleckstrin homology-related domain in SHIP1 mediates membrane localization during Fcγ receptor-induced phagocytosis.
Mui et al., Vancouver, Canada. In Faseb J, 2012
Wild-type (but not the K370A/K397A substituted) full-length SHIP1 protein, reconstitutes normal inhibition of Fcgamma receptor-mediated phagocytosis when introduced into SHIP1(-/-) murine macrophages, reducing the number of phagocytic events by 2-fold
CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl.
Liu et al., Houston, United States. In J Immunol, 2012
The CD2AP/SHIP1 complex and Cbl are recruited to blood dendritic cell (DC) antigen 2 (BDCA2) and Fc fragment of IgE high affinity I receptor (FcepsilonR1)gamma complex after BDCA2 cross-linking in human primary plasmacytoid DCs.
Lineage extrinsic and intrinsic control of immunoregulatory cell numbers by SHIP.
Kerr et al., Tampa, United States. In Eur J Immunol, 2012
Ship1 controls myeloid-derived suppresso cell numbers, in part, by limiting production of the myelopoietic growth factor G-CSF.
The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.
Veillette et al., Montréal, Canada. In Immunity, 2012
SAP prevents the inhibitory function of SLAM family receptors. This effect is Fyn-independent & correlates with uncoupling of SLAM family receptors from SHIP-1.
The role of SHIP in the development and activation of mouse mucosal and connective tissue mast cells.
Krystal et al., Vancouver, Canada. In J Immunol, 2012
SHIP delays the maturation of all three mast cell subsets and, surprisingly, that it is a positive regulator of IgE-induced bone marrow-derived mast cells survival.
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