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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Sonic hedgehog

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Gli, CAN, Smo, V1a, HAD
Papers using Shh antibodies
A paracrine requirement for hedgehog signalling in cancer.
Orsulic Sandra, In PLoS ONE, 2007
... Incubation of the sections with the anti-Shh monoclonal antibody ab53281 (Abcam, Cambridge, MA) diluted 1∶2000 ...
The vacuolar DHHC-CRD protein Pfa3p is a protein acyltransferase for Vac8p.
Zhang Shuguang, In PLoS ONE, 2004
... Anti-Shh antibodies were purchased from Santa Cruz Biotechnology.
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
Salic Adrian et al., In The Journal of Cell Biology, 2003
... antiubiquitin antibody (Enzo Life Sciences, Inc.), rabbit anticalnexin antibody (Abcam), rabbit antigigantin antibody (Abcam), rabbit anti-Shh (Cell Signaling Technology), protein G–agarose (GE ...
Effect of asphyxia on non-protein-bound iron and lipid peroxidation in newborn infants.
Pasquini Juana M et al., In ASN NEURO, 2002
... Anti-Sonic hedgehog (Shh) was a gift generously given by Dr Andrés Carrasco and anti-PDGFRα was purchased from Santa Cruz Biotechnology (Santa Cruz, CA, U.S.A.) ...
Papers on Shh
Targeting hedgehog signaling pathway in pediatric tumors: in vitro evaluation of SMO and GLI inhibitors.
Lanvers-Kaminsky et al., Berlin, Germany. In Cancer Chemother Pharmacol, Feb 2016
RESULTS: Key members of hedgehog signaling (SHH, PTCH1, SMO, GLI1, GLI2 and SUFU) were expressed in all cell lines.
Cis-regulatory programs in the development and evolution of vertebrate paired appendages.
Shubin et al., Chicago, United States. In Semin Cell Dev Biol, Feb 2016
Here, we trace the evolutionary history of transcriptional control of three loci key to vertebrate appendage development (Fgf8, Shh, and HoxD/A).
Sonic hedgehog delivery from self-assembled nanofiber hydrogels reduces the fibrotic response in models of erectile dysfunction.
Podlasek et al., Chicago, United States. In Acta Biomater, Feb 2016
We propose that sonic hedgehog (SHH) and neural innervation, are indispensable regulators of collagen in the penis, with decreased SHH protein being an integral component of the fibrotic response to loss of innervation.
WNT-SHH Antagonism Specifies and Expands Stem Cells prior to Niche Formation.
Fuchs et al., United States. In Cell, Feb 2016
Using immunofluorescence, live imaging, genetics, cell-cycle analyses, in utero lentiviral transduction, and lineage-tracing, we show that in developing hair buds, SCs are born from asymmetric divisions that differentially display WNT and SHH signaling.
Ectonucleotidase activity and immunosuppression in astrocyte-CD4 T cell bidirectional signaling.
Grassi et al., Rozzano, Italy. In Oncotarget, Feb 2016
CD39 activity in T cells in turn inhibits spontaneous calcium oscillations in astrocytes that correlated with enhanced and reduced transcription of CCL2 chemokine and Sonic hedgehog (Shh), respectively.
The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.
Roussel et al., Memphis, United States. In Cancer Cell, Feb 2016
c-Myc (Myc) or MycN overexpression in granule neuron progenitors (GNPs) induces Group 3 (G3) or Sonic Hedgehog (SHH) MBs, respectively.
Sonic Hedgehog Improves Ischemia-Induced Neovascularization by Enhancing Endothelial Progenitor Cell Function in Type 1 Diabetes.
Luo et al., Guangzhou, China. In Mol Cell Endocrinol, Feb 2016
UNASSIGNED: The Sonic hedgehog (Shh) pathway is downregulated in type 1 diabetes, and it has been reported that augmentation of this pathway may alleviate diabetic complications.
Sonic Hedgehog regulates thymic epithelial cell differentiation.
Crompton et al., London, United Kingdom. In J Autoimmun, Feb 2016
UNASSIGNED: Sonic Hedgehog (Shh) is expressed in the thymus, where it regulates T cell development.
Key Signaling Pathways in the Muscle-Invasive Bladder Carcinoma: Clinical Markers for Disease Modeling and Optimized Treatment.
Startsev et al., Moscow, Russia. In Int J Cancer, Dec 2015
Similarly, the 'bell-shape' dynamics of Shh expression levels may suggest aggressive MIBC.
Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration.
Morrisey et al., Philadelphia, United States. In Nature, Nov 2015
Epithelial-specific deletion of sonic hedgehog (Shh) during postnatal homeostasis in the murine lung results in a proliferative expansion of the adjacent lung mesenchyme.
Basal cell nevus syndrome: clinical and molecular review and case report.
Lupi et al., Rio de Janeiro, Brazil. In Int J Dermatol, Oct 2015
PTCH inhibits signaling by the membrane protein Smoothened (Smo), and this inhibition is relieved by binding sonic hedgehog (SHH) to PTCH.
Cancer-associated fibroblasts in pancreatic adenocarcinoma.
Zhao et al., Beijing, China. In Future Oncol, Sep 2015
Cancer cells, normal fibroblasts, normal epithelial cells as well as bone marrow-derived myofibroblasts contribute to the emergence of CAFs through various cytokines (e.g., TGF-β, SHH, PDGF) and epithelial-to-mesenchymal transition.
Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.
Gajjar et al., Memphis, United States. In J Clin Oncol, Sep 2015
PURPOSE: Two phase II studies assessed the efficacy of vismodegib, a sonic hedgehog (SHH) pathway inhibitor that binds smoothened (SMO), in pediatric and adult recurrent medulloblastoma (MB).
dsRNA Released by Tissue Damage Activates TLR3 to Drive Skin Regeneration.
Garza et al., Baltimore, United States. In Cell Stem Cell, Sep 2015
TLR3 activation promotes expression of hair follicle stem cell markers and induces elements of the core hair morphogenetic program, including ectodysplasin A receptor (EDAR) and the Wnt and Shh pathways.
The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma.
Marzban et al., Winnipeg, Canada. In Mol Brain, 2014
The SHH group of MBs originate from cerebellar granule cell precursors in the external germinal zone of the embryonic cerebellum.
Sonic hedgehog acts cell-autonomously on muscle precursor cells to generate limb muscle diversity.
Borycki et al., Sheffield, United Kingdom. In Genes Dev, 2012
Sonic hedgehog from the zone of polarizing activity drives myogenesis specifically within the ventral muscle mass
Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.
Weatherbee et al., New Haven, United States. In Dev Biol, 2012
Data show that Transmembrane protein 107 (Tmem107) is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types.
β-Catenin signaling specifies progenitor cell identity in parallel with Shh signaling in the developing mammalian thalamus.
Nakagawa et al., Minneapolis, United States. In Development, 2012
beta-catenin has multiple functions during thalamic neurogenesis and that both Shh and beta-catenin pathways are important for specifying distinct types of thalamic progenitor cells
Sonic hedgehog maintains cellular and neurochemical homeostasis in the adult nigrostriatal circuit.
Kottmann et al., New York City, United States. In Neuron, 2012
interruption of a non cell-autonomous mode of sonic hedgehog (Shh) signaling originating from dopaminergic neurons causes deficits reminiscent of Parkinson's disease.
Detection of canonical hedgehog signaling in breast cancer by 131-iodine-labeled derivatives of the sonic hedgehog protein.
Woodward et al., Newark, United States. In J Biomed Biotechnol, 2011
These studies show that (1)(3)(1)I-SHH is capable of in vivo detection of breast tumors with high HH signaling.
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