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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Src homology 2 domain-containing transforming protein B

SHB
Top mentioned proteins: Src, CAN, Epidermal Growth Factor, Insulin, V1a
Papers on SHB
The role of the Src Homology-2 domain containing protein B (SHB) in β cells.
Review
New
Åkerblom et al., Uppsala, Sweden. In J Mol Endocrinol, Jan 2016
This review will describe the SH2-domain signaling protein Src Homology-2 domain containing protein B (SHB) and its role in various physiological processes relating in particular to glucose homeostasis and β cell function.
SHOEBOX Modulates Root Meristem Size in Rice through Dose-Dependent Effects of Gibberellins on Cell Elongation and Proliferation.
New
Xu et al., Wuhan, China. In Plos Genet, Aug 2015
Here, we report our findings on shoebox (shb), a mild gibberellin (GA) deficient rice mutant that has a short root meristem size.
Shb deficiency in endothelium but not in leucocytes is responsible for impaired vascular performance during hindlimb ischaemia.
New
Welsh et al., Uppsala, Sweden. In Acta Physiol (oxf), Jun 2015
Shb-deficient mice display both vascular and myeloid cell abnormalities with possible consequences for recovery after hindlimb ischaemia.
Clinical significance and usefulness of soluble heparin binding-epidermal growth factor in gastric cancer.
New
Lim et al., Seoul, South Korea. In World J Gastroenterol, Mar 2015
AIM: To evaluate the clinical usefulness of soluble heparin-binding epidermal growth factor (sHB-EGF) as a serum biomarker for gastric cancer (GC).
Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets.
Welsh et al., Uppsala, Sweden. In J Endocrinol, 2014
The Src homology-2 domain containing protein B (SHB) has previously been shown to function as a pleiotropic adapter protein, conveying signals from receptor tyrosine kinases to intracellular signaling intermediates.
The Soluble Heparin-Binding EGF-Like Growth Factor Stimulates EGF Receptor Trafficking to the Nucleus.
Komisarenko et al., Ukraine. In Plos One, 2014
Soluble form of heparin-binding EGF-like growth factor (sHB-EGF) is one of the ligands for EGFR in many cell types; however, there is no evidence for the ability of sHB-EGF to induce EGFR nuclear importation.
Biomechanical Stability of Dental Implants in Augmented Maxillary Sites: Results of a Randomized Clinical Study with Four Different Biomaterials and PRF and a Biological View on Guided Bone Regeneration.
Izabela et al., Vienna, Austria. In Biomed Res Int, 2014
This study investigates on a clinical level the biomechanical stability of augmented sites in maxillary bone when a new class of moldable, self-hardening calcium-phosphate biomaterials (SHB) is used with and without the addition of Platelet Rich Fibrin (aPRF) in the Piezotome-enhanced subperiosteal tunnel-technique (PeSPTT).
Vascular dysfunction and increased metastasis of B16F10 melanomas in Shb deficient mice as compared with their wild type counterparts.
Welsh et al., Uppsala, Sweden. In Bmc Cancer, 2014
BACKGROUND: Shb is a signaling protein downstream of vascular endothelial growth factor receptor-2 and Shb deficiency has been found to restrict tumor angiogenesis.
Vascular adaptation to a dysfunctional endothelium as a consequence of Shb deficiency.
GeneRIF
Welsh et al., Uppsala, Sweden. In Angiogenesis, 2012
Shb knockout mouse exhibited structural and functional (angiogenesis and vascular permeability) vascular abnormalities that have implications for understanding the function of VEGF-A under physiological conditions
Heterogeneity among RIP-Tag2 insulinomas allows vascular endothelial growth factor-A independent tumor expansion as revealed by studies in Shb mutant mice: implications for tumor angiogenesis.
GeneRIF
Welsh et al., Uppsala, Sweden. In Mol Oncol, 2012
Data show reduced VEGF-A expression in Shb-deficient tumors.Interference with Shb signaling may provide novel means for future cancer therapy.
Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells.
GeneRIF
Welsh et al., Uppsala, Sweden. In Bmc Immunol, 2010
Shb appears to play an important modulating role on T- Cell receptor signaling, thus regulating the peripheral CD4+ T(H)2 cell response.
The Src homology 2 domain-containing adapter protein B (SHB) regulates mouse oocyte maturation.
GeneRIF
Welsh et al., Uppsala, Sweden. In Plos One, 2009
It is concluded that SHB regulates normal oocyte and follicle development and that perturbation of SHB signaling causes defective meiosis I and early embryo development
Impaired glucose homeostasis in Shb-/- mice.
GeneRIF
Welsh et al., Uppsala, Sweden. In J Endocrinol, 2009
loss of Shb impairs insulin secretion, alters islet microvascular morphology, and increases the basal blood glucose concentration.
[Heparin-binding epidermal growth factor (HB-EGF): myth or reality?].
Review
Failla et al., Catania, Italy. In Clin Ter, 2008
HB-EGF was initially identified as a secreted product of human macrophage-like cells, it is sinthetized as a transmembrana protein; proHB-EGF; that is shed by specific metalloproteases, releasing soluble growth factor(sHB-EGF).
Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis.
Review
Mugishima et al., Tokyo, Japan. In J Atheroscler Thromb, 2006
Phosphorylated Y1175 creates a binding site for phospholipase Cgamma1 (PLC-gamma1) and Shb.
Metalloproteinase-mediated shedding of heparin-binding EGF-like growth factor and its pathophysiological roles.
Review
Higashiyama, Japan. In Protein Pept Lett, 2004
Heparin-binding EGF-like growth factor (HB-EGF) exists as a membrane-anchored form (proHB-EGF) and as its soluble cleaved product (sHB-EGF).
The FRK/RAK-SHB signaling cascade: a versatile signal-transduction pathway that regulates cell survival, differentiation and proliferation.
Review
Welsh et al., Cambridge, United States. In Curr Mol Med, 2003
Recent experiments have unravelled novel signal transduction pathways that involve the SRC homology 2 (SH2) domain adapter protein SHB.
Specification of subunit assembly by the hydrophilic amino-terminal domain of the Shaker potassium channel.
Impact
Jan et al., San Francisco, United States. In Science, 1992
A Drosophila Shaker B (ShB) potassium channel truncated polypeptide that contains only the hydrophilic amino-terminal domain can form a homomultimer; the minimal requirement for the homophilic interaction has been localized to a fragment of 114 amino acids.
Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel.
Impact
Jan et al., San Francisco, United States. In Nature, 1991
Fast inactivation of Na+ and K+ channels may result from the blocking of the permeation pathway by a positively charged cytoplasmic gate such as the one encoded by the first 20 amino acids of the Shaker B (ShB) K+ channel.
Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB.
Impact
Aldrich et al., Stanford, United States. In Science, 1990
The model was tested by the internal application of a synthetic peptide, with the sequence of the first 20 residues of the ShB alternatively spliced variant, to noninactivating mutant channels expressed in Xenopus oocytes.
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