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SH3 and multiple ankyrin repeat domains 1

Shank1, SSTRIP, Synamon, Shank1a
a scaffold protein in the post synaptic density that forms a complex with GKAP and PSD-95 [RGD, Feb 2006] (from NCBI)
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Papers on Shank1
SHANK1 Deletions in Males with Autism Spectrum Disorder.
Scherer et al., Toronto, Canada. In Am J Hum Genet, 2012
A hemizygous SHANK1 deletion segregates in a four-generation family in which male carriers--but not female carriers--have autism spectrum disorder with higher functioning.
A promoter variant of SHANK1 affects auditory working memory in schizophrenia patients and in subjects clinically at risk for psychosis.
Mössner et al., Bonn, Germany. In Eur Arch Psychiatry Clin Neurosci, 2012
The results of this study suggested a role of SHANK1 in working memory deficits in schizophrenia.
The structural flexibility of the shank1 PDZ domain is important for its binding to different ligands.
Eom et al., Inch'ŏn, South Korea. In Biochem Biophys Res Commun, 2011
this study provides a new level of understanding of the specificity and structural plasticity of the shank PDZ domain.
Sociability and motor functions in Shank1 mutant mice.
Crawley et al., Bethesda, United States. In Brain Res, 2011
Shank1 null mice do not demonstrate autism-relevant social interaction deficits, but confirm and extend a role for Shank1 in motor functions.
Communication impairments in mice lacking Shank1: reduced levels of ultrasonic vocalizations and scent marking behavior.
Crawley et al., Bethesda, United States. In Plos One, 2010
The reduced levels of ultrasonic vocalizations and scent marking behavior in Shank1(-/-) mice are consistent with a phenotype relevant to social communication deficits in autism.
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