INPP4B is an oncogenic regulator in human colon cancer.
China. In Oncogene, Oct 2015
Here we show that silencing of INPP4B blocks activation of Akt and serum- and glucocorticoid-regulated kinase 3 (SGK3), inhibits colon cancer cell proliferation and retards colon cancer xenograft growth.
SGK3 (CISK) may induce tumor angiogenesis (Hypothesis).
Guangzhou, China. In Oncol Lett, Jul 2015
UNASSIGNED: Serum- and glucocorticoid-inducible protein kinase 3 (SGK3), also known as cytokine-independent survival kinase (CISK), encoded by chromosome 8q12.2, is a downstream mediator of phosphatidylinositol 3-kinase (PI3K) oncogenic signaling.
SGK regulation of renal sodium transport.
Stanford, United States. In Curr Opin Nephrol Hypertens, 2012
Less is known about the function of SGK2 or SGK3, but both kinases can regulate Na(+)/H(+) exchanger 3 (NHE3) activity.