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Serum/glucocorticoid regulated kinase family, member 3

SGK3, SGK2, CISK
This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SGK1, Akt, PDK1, PI3K, Ubiquitin
Papers on SGK3
Serum- and Glucocorticoid-Inducible Kinase SGK2 Regulates Human Organic Anion Transporters 4 via Ubiquitin Ligase Nedd4-2.
New
You et al., United States. In Biochem Pharmacol, Jan 2016
In the current study, we examined the regulation of hOAT4 by serum- and glucocorticoid-inducible kinase 2 (sgk2) in the kidney COS-7 cells.
INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas.
New
Zhang et al., Newcastle, Australia. In Oncotarget, Dec 2015
Here we report that INPP4B can function as an oncogenic driver through activation of serum- and glucocorticoid-regulated kinase 3 (SGK3) in melanoma.
INPP4B is an oncogenic regulator in human colon cancer.
New
Jiang et al., China. In Oncogene, Oct 2015
Here we show that silencing of INPP4B blocks activation of Akt and serum- and glucocorticoid-regulated kinase 3 (SGK3), inhibits colon cancer cell proliferation and retards colon cancer xenograft growth.
Crystal structure of designed PX domain from cytokine-independent survival kinase and implications on evolution-based protein engineering.
New
Zhang et al., Ann Arbor, United States. In J Struct Biol, Aug 2015
In this study, we report the X-ray crystallographic structure of a designed PX domain from the cytokine-independent survival kinase (CISK), which has been implicated as functioning in parallel with PKB/Akt in cell survival and insulin responses.
SGK3 (CISK) may induce tumor angiogenesis (Hypothesis).
New
Ke et al., Guangzhou, China. In Oncol Lett, Jul 2015
UNASSIGNED: Serum- and glucocorticoid-inducible protein kinase 3 (SGK3), also known as cytokine-independent survival kinase (CISK), encoded by chromosome 8q12.2, is a downstream mediator of phosphatidylinositol 3-kinase (PI3K) oncogenic signaling.
MiR-212-3p inhibits glioblastoma cell proliferation by targeting SGK3.
New
Zhao et al., Harbin, China. In J Neurooncol, May 2015
In this study, we showed that miR-212-3p expression was significantly down-regulated and negatively correlated with serum and glucocorticoid-inducible kinase 3 (SGK3) in GBM.
PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets.
New
Ronai et al., Bethesda, United States. In Cancer Res, May 2015
The PDK1 substrate SGK3 was determined to be an important mediator of PDK1 activities in melanoma cells.
Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis.
Negishi et al., United States. In Sci Rep, 2014
Statins utilize pregnane X receptor (PXR) and serum/glucocorticoid regulated kinase 2 (SGK2) to activate phosphoenolpyruvate carboxykinase 1 (PEPCK1) and glucose-6-phosphatase (G6Pase) genes, thereby increasing glucose production in human liver cells.
Loss of serum and glucocorticoid-regulated kinase 3 (SGK3) does not affect proliferation and survival of multiple myeloma cell lines.
Stühmer et al., Würzburg, Germany. In Plos One, 2014
Here we explore whether serum and glucocorticoid-regulated kinase 3 (SGK3), a potential downstream effector of PI3K, plays a role in oncogenic signalling in MM cells--either in concert with or independent of Akt.
AKT-independent PI3-K signaling in cancer - emerging role for SGK3.
Review
Sheppard et al., Melbourne, Australia. In Cancer Manag Res, 2012
Importantly, there is emerging evidence demonstrating that SGK3 plays a critical role in AKT-independent oncogenic signaling.
SGK regulation of renal sodium transport.
Review
Pao, Stanford, United States. In Curr Opin Nephrol Hypertens, 2012
Less is known about the function of SGK2 or SGK3, but both kinases can regulate Na(+)/H(+) exchanger 3 (NHE3) activity.
SGK3 is associated with estrogen receptor expression in breast cancer.
GeneRIF
Liu et al., Houston, United States. In Breast Cancer Res Treat, 2012
A positive correlation between SGK3 expression and breast tumor prognosis.
Serum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinoma.
GeneRIF
Guan et al., Hong Kong, Hong Kong. In Hepatology, 2012
found that expression of SGK3, which like AKT is activated by PI3K/PDK1 signaling, has more significance than overexpression of AKT in predicting poor outcome in hepatocellular carcinoma patients
Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice.
GeneRIF
Pearce et al., San Francisco, United States. In Mol Endocrinol, 2011
SGK3 plays a previously unappreciated role in glucose homeostasis, likely through direct effects within pancreatic beta-cells, to stimulate proliferation and insulin release
An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.
GeneRIF
Tamura et al., Hannover, Germany. In Rna, 2011
show here that DNA damage drastically decreased the cytoplasmic pool of a set of THOC5-dependent mRNAs and impaired the THOC5/mRNA complex formation
Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids.
GeneRIF
Yun et al., Atlanta, United States. In Mol Biol Cell, 2011
The study identifies SGK3 as a novel endosomal kinase that acutely regulates Na(+)/H(+) exchanger 3 (NHE3) in a PI3K-dependent mechanism.
Second AKT: the rise of SGK in cancer signalling.
Review
Sheppard et al., Melbourne, Australia. In Growth Factors, 2010
The serum and glucocorticoid kinase (SGK) family of serine/threonine kinases consists of three isoforms, SGK-1, SGK-2 and SGK-3.
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.
Impact
Garraway et al., Boston, United States. In Cancer Cell, 2009
Instead, these cells retain robust PDK1 activation and membrane localization and exhibit dependency on the PDK1 substrate SGK3.
(Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms.
Review
Impact
Vallon et al., Tübingen, Germany. In Physiol Rev, 2006
Similar to its isoforms SGK2 and SGK3, SGK1 is activated by insulin and growth factors via phosphatidylinositol 3-kinase and the 3-phosphoinositide-dependent kinase PDK1.
Serum and glucocorticoid-regulated protein kinases: variations on a theme.
Review
Woodgett et al., Toronto, Canada. In J Cell Biochem, 2006
However, in addition to PH domains, a second class of 3' phosphorylated inositol phospholipid-binding domains exists that is termed Phox homology (PX) domain: this domain is found in one of the SGKs (SGK3).
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