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SGK223 homolog of rat pragma of Rnd2

SgK223, Pragmin
Top mentioned proteins: V1a, Src, fibrillin-1, CAN, RhoA
Papers on SgK223
Quantitative proteomics reveals protein kinases and phosphatases in the individual phases of contextual fear conditioning in the C57BL/6J mouse.
New
Li et al., Vienna, Austria. In Behav Brain Res, Jan 2016
In addition, our analysis showed protein kinases WNK1, LYN, VRK1, ABL1, CDK4, CDKL3, SgK223 and ADCK1, and protein phosphatases PTPRF, ACP1, DNAJC6, SSH2 and UBASH3B that have not been directly linked to fear memory processes so far.
The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling.
Daly et al., Sydney, Australia. In Mol Cancer, 2014
SgK223, also known as Pragmin, is a pseudokinase and scaffolding protein closely related to SgK269/PEAK1.
Bacterial EPIYA effectors--where do they come from? What are they? Where are they going?
Review
Hatakeyama et al., Tokyo, Japan. In Cell Microbiol, 2013
A search of mammalian proteomes revealed the presence of a mammalian EPIYA-containing protein, Pragmin, which potentiates Src family kinase (SFK) activity by binding and sequestrating the SFK inhibitor Csk upon EPIYA phosphorylation.
Mammalian Pragmin regulates Src family kinases via the Glu-Pro-Ile-Tyr-Ala (EPIYA) motif that is exploited by bacterial effectors.
GeneRIF
Hatakeyama et al., Tokyo, Japan. In Proc Natl Acad Sci U S A, 2011
Pragmin as a mammalian EPIYA effector and suggests that bacterial EPIYA effectors target Pragmin to subvert SFKs for successful infection.
The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.
Graeber et al., Los Angeles, United States. In Oncogene, 2010
We also identified novel components of the inner core complexes, including the kinases Pragmin (Sgk223) and Lrrk1 (Lrrk2 paralog).
Integrated genomic profiling identifies candidate genes implicated in glioma-genesis and a novel LEO1-SLC12A1 fusion gene.
French et al., Rotterdam, Netherlands. In Genes Chromosomes Cancer, 2010
We identified a homozygous deletion spanning the Pragmin gene in one sample, but direct sequencing of all coding exons in 20 other glioma samples failed to detect additional genetic changes.
Quantitative phosphoproteomics reveals a cluster of tyrosine kinases that mediates SRC invasive activity in advanced colon carcinoma cells.
Roche et al., Montpellier, France. In Cancer Res, 2009
Interestingly, Src also phosphorylated a cluster of tyrosine kinases, i.e., the receptors Met and EphA2, the cytoplasmic tyrosine kinase Fak, and pseudo-tyrosine kinase SgK223, which were required for its invasive activity.
Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity.
GeneRIF
Negishi et al., Kyoto, Japan. In J Biol Chem, 2006
Rnd2 regulates neurite outgrowth by functioning as the RhoA activator through Pragmin, in contrast to Rnd1 and Rnd3 inhibiting RhoA signaling
The protein kinase complement of the human genome.
Impact
GeneRIF
Sudarsanam et al., San Francisco, United States. In Science, 2003
Also known as SgK223, a member of the NKF3 subfamily of eukaryotic protein kinases.
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