Saikosaponin D acts against corticosterone-induced apoptosis via regulation of mitochondrial GR translocation and a GR-dependent pathway.
Beijing, China. In Prog Neuropsychopharmacol Biol Psychiatry, 14 Apr 2014
Next, mPTP, MMP, [Ca(2+)]i, translocation of the GR to the nucleus and western blot analyses for caspase-3, caspase-9, cytochrome C, GR, GILZ, SGK-1, NF-Κb (p65), IκB-α, Bad, Akt, HSP90 and HDAC-6 were investigated.
AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases.
Frankfurt am Main, Germany. In Biochim Biophys Acta, Jul 2013
The group of AGC protein kinases includes more than 60 protein kinases in the human genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK, NDR, MAST, YANK, DMPK, GRK and SGK494.