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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 30 Jun 2015.

Serum/glucocorticoid regulated kinase 1

SGK1, SGK
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: Akt, ENaC, V1a, Insulin, CAN
Papers using SGK1 antibodies
Biphasic effects of ANP infusion in conscious, euvolumic rats: roles of AQP2 and ENaC trafficking
Supplier
Sands Jeff M., In PLoS ONE, 2005
... Antibodies used included anti-actin (Sigma), anti-SGK (serum and glucocorticoid-induced kinase) (Cell Signaling Technology, Beverly, MA) and ...
Papers on SGK1
ROLE OF NON-GENOMIC SIGNALLING PATHWAYS ACTIVATED BY ALDOSTERONE DURING CARDIAC REPERFUSION INJURY.
New
Mihailidou et al., Jackson, United States. In Mol Endocrinol, 29 Jul 2015
Aldo-PEG had no effect on MR-dependent transcriptional activation whereas Aldo increased transcript levels of serum-regulated kinase 1 (Sgk-1) and plasminogen activator inhibitor-1 (PAI-1).
Glucocorticoid Receptor Activation Inhibits Chemotherapy-induced Cell Death in High-grade Serous Ovarian Carcinoma.
New
Conzen et al., Chicago, United States. In Gynecol Oncol, 23 Jul 2015
In vitro assays showed that in GR-positive HeyA8 and SKOV3 cells, dexamethasone (100 nM) treatment upregulated the pro-survival genes SGK1 and MKP1/DUSP1 and inhibited carboplatin/gemcitabine-induced cell death.
Altered Markers of Cortical γ-Aminobutyric Acid Neuronal Activity in Schizophrenia: Role of the NARP Gene.
New
Lewis et al., Nara, Japan. In Jama Psychiatry, 03 Jul 2015
Objective: To quantify in individuals with schizophrenia the expression of immediate early genes (NARP, ARC, and SGK1) regulating glutamate synaptic neurotransmission.
SGK1 inhibits cellular apoptosis and promotes proliferation via the MEK/ERK/p53 pathway in colitis.
New
Tang et al., Nanjing, China. In World J Gastroenterol, 28 Jun 2015
AIM: To investigate the role of serum-and-glucocorticoid-inducible-kinase-1 (SGK1) in colitis and its potential pathological mechanisms.
Disturbance of oligodendrocyte function plays a key role in the pathogenesis of schizophrenia and major depressive disorder.
Review
New
Tohyama et al., Ōsaka, Japan. In Biomed Res Int, Dec 2014
We have reported that repeated stressful events, one of the major risk factors of MDD, can induce sustained upregulation of plasma corticosterone levels and serum/glucocorticoid regulated kinase 1 (Sgk1) mRNA expression in oligodendrocytes.
Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans.
New
Dong et al., Beijing, China. In Plos One, Dec 2014
Here we report that in C. elegans sgk-1 null mutants, GFP-tagged MIG-14/Wntless, the sorting receptor of Wnt, failed to localize to the basolateral membrane of intestinal cells; instead, it was mis-sorted to lysosomes.
The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.
New
Impact
Powell et al., Baltimore, United States. In Nat Immunol, May 2014
SGK1 is an AGC kinase that regulates the expression of membrane sodium channels in renal tubular cells in a manner dependent on the metabolic checkpoint kinase complex mTORC2.
Relevance of SGK1 in structural, functional and molecular alterations produced by aldosterone in heart.
Review
New
Lahera et al., In Horm Mol Biol Clin Investig, May 2014
SGK1 is a member of the serine/threonine kinase gene family that plays an important role in the absorption of Na+ and water through the Na+ channel in the apical membrane of tubular epithelial cells.
Regulation of transport across cell membranes by the serum- and glucocorticoid-inducible kinase SGK1.
Review
New
Alesutan et al., Tübingen, Germany. In Mol Membr Biol, Feb 2014
The serum- and glucocorticoid-inducible kinase 1 (SGK1) is genomically upregulated by cell stress including energy depletion and hyperosmotic shock as well as a variety of hormones including glucocorticoids, mineralocorticoids and TGFβ.
The sodium chloride cotransporter SLC12A3: new roles in sodium, potassium, and blood pressure regulation.
Review
Hoorn et al., Rotterdam, Netherlands. In Pflugers Arch, 2014
This complex network consists of kinases and ubiquitinases, including WNKs, SGK1, SPAK, Nedd4-2, Cullin-3, and Kelch-like 3. The pathophysiological significance of this network is illustrated by the fact that modification of each individual protein in the network changes NCC activity and results in salt-dependent hypotension or hypertension.
Drug elucidation: invertebrate genetics sheds new light on the molecular targets of CNS drugs.
Review
Buttner et al., Shreveport, United States. In Front Pharmacol, 2013
Similarly, novel targets of antidepressant drugs and lithium have been identified in C. elegans, including lipid-binding/transport proteins and the SGK-1 signaling pathway, respectively.
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1.
Impact
Kuchroo et al., Boston, United States. In Nature, 2013
We identified serum glucocorticoid kinase 1 (SGK1), a serine/threonine kinase, as an essential node downstream of IL-23 signalling.
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Impact
Hafler et al., New Haven, United States. In Nature, 2013
High-salt conditions activate the p38/MAPK pathway involving nuclear factor of activated T cells 5 (NFAT5; also called TONEBP) and serum/glucocorticoid-regulated kinase 1 (SGK1) during cytokine-induced TH17 polarization.
Serum-glucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis.
GeneRIF
Du et al., Beijing, China. In Arterioscler Thromb Vasc Biol, 2012
SGK1 may play an important role in macrophage recruitment and M2 macrophage activation by activating the STAT3 pathway, which leads to angiotensin II-induced cardiac fibrosis.
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.
Impact
Hall et al., Basel, Switzerland. In Cell Metab, 2012
Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates and activates AGC kinase family members, including Akt, SGK1, and PKC, in response to insulin/IGF1.
Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype.
GeneRIF
Staub et al., Lausanne, Switzerland. In Am J Physiol Renal Physiol, 2012
The impaired ability of Sgk1 knockout mice to retain Na+ increased significantly with a low-salt diet despite higher plasma aldosterone levels. On a low-Na+ diet, the Sgk1 knockout mice were also hyperkaliuric and lost body weight.
Serum- and glucocorticoid-dependent kinase-1-induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor.
GeneRIF
Stournaras et al., Tübingen, Germany. In Febs J, 2012
Data show that SGK1 regulates cell migration via vinculin dephosphorylation, a mechanism that is controlled by membrane androgen receptor function.
Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways.
GeneRIF
Park et al., Kwangju, South Korea. In Plos One, 2011
SGK1 is a gamma-secretase regulator presumably effective through phosphorylation and degradation of NCT.
SGK1 sensitivity of platelet migration.
GeneRIF
Lang et al., Tübingen, Germany. In Cell Physiol Biochem, 2011
SGK1 participates in the signaling of platelet migration
Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure.
Impact
GeneRIF
Brosens et al., London, United Kingdom. In Nat Med, 2010
Data show that deregulated SGK1 activity in cycling endometrium interferes with embryo implantation, leading to infertility, or predisposes to pregnancy complications by rendering the feto-maternal interface vulnerable to oxidative damage.
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