AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases.
Frankfurt am Main, Germany. In Biochim Biophys Acta, Jul 2013
The group of AGC protein kinases includes more than 60 protein kinases in the human genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK, NDR, MAST, YANK, DMPK, GRK and SGK494.
Therapeutic potential of serum and glucocorticoid inducible kinase inhibition.
Tübingen, Germany. In Expert Opin Investig Drugs, Jun 2013
INTRODUCTION: Expression of serum-and-glucocorticoid-inducible kinase-1 (SGK1) is low in most cells, but dramatically increases under certain pathophysiological conditions, such as glucocorticoid or mineralocorticoid excess, inflammation with TGFβ release, hyperglycemia, cell shrinkage and ischemia.