Up-Regulation of FGF23 Release by Aldosterone.
Tübingen, Germany. In Biochem Biophys Res Commun, Feb 2016
The present study explored a putative aldosterone sensitivity of Fgf23 transcription and secretion and the putative involvement of the aldosterone sensitive serum & glucocorticoid inducibe kinase SGK1 and SGK1 sensitive transcription factor NFκB and store operated Ca(2+) entry (SOCE).
Aldosterone Induces Renal Fibrosis and Inflammatory M1-Macrophage Subtype via Mineralocorticoid Receptor in Rats.
Madrid, Spain. In Plos One, Dec 2015
Relative kidney weight, collagen content, fibronectin, macrophage infiltrate, CTGF, Col I, MMP2, TNF-α, CD68, Arg2, and SGK-1 were increased (p<0.05) in aldosterone + salt-treated rats, being reduced by spironolactone (p<0.05).
Sodium chloride, SGK1, and Th17 activation.
Berlin, Germany. In Pflugers Arch, Mar 2015
Recent reports have shown that the differentiation of Th17 cells is sensitive to changes in local microenvironments, in particular salt (NaCl) concentrations, in a molecular mechanism centered around the serum- and glucocorticoid-inducible kinase 1 (SGK1).