The sodium chloride cotransporter SLC12A3: new roles in sodium, potassium, and blood pressure regulation.
Rotterdam, Netherlands. In Pflugers Arch, 2014
This complex network consists of kinases and ubiquitinases, including WNKs, SGK1, SPAK, Nedd4-2, Cullin-3, and Kelch-like 3. The pathophysiological significance of this network is illustrated by the fact that modification of each individual protein in the network changes NCC activity and results in salt-dependent hypotension or hypertension.