The SIN1-PH Domain Connects mTORC2 to PI3K.
Shanghai, China. In Cancer Discov, 30 Nov 2015
The mTOR complex 2, mTORC2, is a critical downstream effector of PI3K that stimulates AGC kinase members, including AKT, PKC, and SGK.
Sodium chloride, SGK1, and Th17 activation.
Berlin, Germany. In Pflugers Arch, Mar 2015
Recent reports have shown that the differentiation of Th17 cells is sensitive to changes in local microenvironments, in particular salt (NaCl) concentrations, in a molecular mechanism centered around the serum- and glucocorticoid-inducible kinase 1 (SGK1).