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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Serum/glucocorticoid regulated kinase 1

SGK1, SGK
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: Akt, ENaC, V1a, Insulin, CAN
Papers using SGK1 antibodies
Biphasic effects of ANP infusion in conscious, euvolumic rats: roles of AQP2 and ENaC trafficking
Supplier
Sands Jeff M., In PLoS ONE, 2005
... Antibodies used included anti-actin (Sigma), anti-SGK (serum and glucocorticoid-induced kinase) (Cell Signaling Technology, Beverly, MA) and ...
Papers on SGK1
The Phosphorylation Of sEndogenous Nedd4-2 In Na(+)-Absorbing Human Airway Epithelial Cells.
New
Wilson et al., Kuala Lumpur, Malaysia. In Eur J Pharmacol, 18 Apr 2014
Serum / glucocorticoid inducible kinase 1 (SGK1) and protein kinase A (PKA) both appear to inhibit this process by phosphorylating Nedd4-2-Ser(221), -Ser(327) and -Thr(246).
Saikosaponin D acts against corticosterone-induced apoptosis via regulation of mitochondrial GR translocation and a GR-dependent pathway.
New
Pan et al., Beijing, China. In Prog Neuropsychopharmacol Biol Psychiatry, 14 Apr 2014
Next, mPTP, MMP, [Ca(2+)]i, translocation of the GR to the nucleus and western blot analyses for caspase-3, caspase-9, cytochrome C, GR, GILZ, SGK-1, NF-Κb (p65), IκB-α, Bad, Akt, HSP90 and HDAC-6 were investigated.
Glucocorticoid Receptor Activity Contributes to Resistance to Androgen-Targeted Therapy in Prostate Cancer.
New
Szmulewitz et al., Chicago, United States. In Horm Cancer, 11 Apr 2014
The glucocorticoid receptor (GR) and AR share several transcriptional targets, including the anti-apoptotic genes serum and g lucocorticoid-regulated kinase 1 (SGK1) and Map kinase phosphatase 1 (MKP1)/dual specificity phosphatase 1 (DUSP1).
Membrane Androgen Receptor Sensitive Na(+)/H(+) Exchanger Activity in Prostate Cancer Cells.
New
Lang et al., Tübingen, Germany. In Febs Lett, 04 Apr 2014
PI3K stimulates serum- and glucocorticoid-inducible kinase SGK1, which in turn activates Na(+)/H(+)-exchangers (NHE).
PPARγ-Induced Stimulation of Amiloride-Sensitive Sodium Current in Renal Collecting Duct Principal Cells is Serum and Insulin Dependent.
New
Renauld et al., Sherbrooke, Canada. In Cell Physiol Biochem, 25 Mar 2014
Transepithelial Na(+) current was measured and the changes in SGK and Nedd4 expression were determined by immunoblotting.
Rapid aldosterone actions on epithelial sodium channel trafficking and cell proliferation.
Review
New
Thomas et al., Dublin, Ireland. In Steroids, Dec 2013
Aldosterone transcriptionally up-regulates the ENaCα subunit and also up regulates serum and glucocorticoid-regulated kinase-1 (SGK1) that indirectly regulates the ubiquitination of ENaC subunits.
AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases.
Review
New
Biondi et al., Frankfurt am Main, Germany. In Biochim Biophys Acta, Jul 2013
The group of AGC protein kinases includes more than 60 protein kinases in the human genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK, NDR, MAST, YANK, DMPK, GRK and SGK494.
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
New
Impact
Hafler et al., New Haven, United States. In Nature, May 2013
High-salt conditions activate the p38/MAPK pathway involving nuclear factor of activated T cells 5 (NFAT5; also called TONEBP) and serum/glucocorticoid-regulated kinase 1 (SGK1) during cytokine-induced TH17 polarization.
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1.
New
Impact
Kuchroo et al., Boston, United States. In Nature, May 2013
We identified serum glucocorticoid kinase 1 (SGK1), a serine/threonine kinase, as an essential node downstream of IL-23 signalling.
Serum and glucocorticoid inducible kinase, metabolic syndrome, inflammation, and tumor growth.
Review
New
Stournaras et al., Tübingen, Germany. In Hormones (athens), Apr 2013
Serum-and-glucocorticoid-inducible-kinase-1 (SGK1) is under regulation of several hormones, mediators and cell stressors.
Kinases as targets for ENaC regulation.
Review
New
Baines, London, United Kingdom. In Curr Mol Pharmacol, Mar 2013
The functions of SGK and PKA are the best understood and both up-regulate ENaC activity.
AKT-independent PI3-K signaling in cancer - emerging role for SGK3.
Review
Sheppard et al., Melbourne, Australia. In Cancer Manag Res, 2012
The serum- and glucocorticoid-inducible protein kinase (SGK) family is made up of three isoforms, SGK1, 2, and 3, that are PI3-K-dependent, serine/threonine kinases, with similar substrate specificity to AKT.
Serum-glucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis.
GeneRIF
Du et al., Beijing, China. In Arterioscler Thromb Vasc Biol, 2012
SGK1 may play an important role in macrophage recruitment and M2 macrophage activation by activating the STAT3 pathway, which leads to angiotensin II-induced cardiac fibrosis.
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.
Impact
Hall et al., Basel, Switzerland. In Cell Metab, 2012
Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates and activates AGC kinase family members, including Akt, SGK1, and PKC, in response to insulin/IGF1.
Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype.
GeneRIF
Staub et al., Lausanne, Switzerland. In Am J Physiol Renal Physiol, 2012
The impaired ability of Sgk1 knockout mice to retain Na+ increased significantly with a low-salt diet despite higher plasma aldosterone levels. On a low-Na+ diet, the Sgk1 knockout mice were also hyperkaliuric and lost body weight.
Serum- and glucocorticoid-dependent kinase-1-induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor.
GeneRIF
Stournaras et al., Tübingen, Germany. In Febs J, 2012
Data show that SGK1 regulates cell migration via vinculin dephosphorylation, a mechanism that is controlled by membrane androgen receptor function.
Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways.
GeneRIF
Park et al., Kwangju, South Korea. In Plos One, 2011
SGK1 is a gamma-secretase regulator presumably effective through phosphorylation and degradation of NCT.
SGK1 sensitivity of platelet migration.
GeneRIF
Lang et al., Tübingen, Germany. In Cell Physiol Biochem, 2011
SGK1 participates in the signaling of platelet migration
Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure.
Impact
GeneRIF
Brosens et al., London, United Kingdom. In Nat Med, 2010
Data show that deregulated SGK1 activity in cycling endometrium interferes with embryo implantation, leading to infertility, or predisposes to pregnancy complications by rendering the feto-maternal interface vulnerable to oxidative damage.
Extensive in vivo metabolite-protein interactions revealed by large-scale systematic analyses.
Impact
Snyder et al., Stanford, United States. In Cell, 2010
It is required for the activity of Ypk1, a mammalian AKT/SGK kinase homolog.
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