Regulation of Orai1/STIM1 by the kinases SGK1 and AMPK.
Tübingen, Germany. In Cell Calcium, Nov 2012
Phosphorylation of Nedd4-2 by the serum and glucocorticoid inducible kinase SGK1 leads to the binding of Nedd4-2 to the protein 14-3-3 thus preventing its interaction with Orai1.
SGK regulation of renal sodium transport.
Stanford, United States. In Curr Opin Nephrol Hypertens, Sep 2012
OBJECTIVE: The serum and glucocorticoid regulated kinase (SGK) family of protein kinases shares similar biochemical and hormonal signaling properties; however, the SGK kinases also exhibit distinct differences in regulating renal sodium (Na(+)) transport.
Organization of the ENaC-regulatory machinery.
San Francisco, United States. In Crit Rev Biochem Mol Biol, Jul 2012
Na(+) transport in this segment is strongly regulated by the salt-retaining hormone, aldosterone, which acts through the mineralocorticoid receptor (MR) to influence the expression of a selected set of target genes, most notably the serine-threonine kinase SGK1, which phosphorylates and inhibits the E3 ubiquitin ligase Nedd4-2.