Synthesis of pro-apoptotic indapamide derivatives as anticancer agents.
Kocaeli, Turkey. In J Enzyme Inhib Med Chem, 16 Mar 2015
Compound 12 (SGK 266) was evaluated in vitro using the MTT colorimetric method against melanoma cancer cell line MDA-MB435 growth inhibition for different doses and exhibited anticancer activity with IC50 values of 85-95 µM against melanoma cancer cell line MDA-MB435.
Implying analytic measures for unraveling rheumatoid arthritis significant proteins through drug target interaction.
Coimbatore, India. In Interdiscip Sci, 06 Mar 2015
Traffic values and centrality parameters were applied as the selection criteria for identifying potential targets from the important hubs which resulted into FOS, KNG1, PTGDS, HSP90AA1, REN, POMC, FCER1G, IL6, ICAM1, SGK1, NOS3 and PLA2G4A.
The sodium chloride cotransporter SLC12A3: new roles in sodium, potassium, and blood pressure regulation.
Rotterdam, Netherlands. In Pflugers Arch, 2014
This complex network consists of kinases and ubiquitinases, including WNKs, SGK1, SPAK, Nedd4-2, Cullin-3, and Kelch-like 3. The pathophysiological significance of this network is illustrated by the fact that modification of each individual protein in the network changes NCC activity and results in salt-dependent hypotension or hypertension.