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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Jul 2015.

Serum/glucocorticoid regulated kinase 1

SGK1, SGK
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: Akt, ENaC, V1a, Insulin, CAN
Papers using SGK1 antibodies
Biphasic effects of ANP infusion in conscious, euvolumic rats: roles of AQP2 and ENaC trafficking
Supplier
Sands Jeff M., In PLoS ONE, 2005
... Antibodies used included anti-actin (Sigma), anti-SGK (serum and glucocorticoid-induced kinase) (Cell Signaling Technology, Beverly, MA) and ...
Papers on SGK1
Phosphorylation of FE65 Serine-610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing.
New
Lau et al., Hong Kong, Hong Kong. In Biochem J, 17 Aug 2015
Here, we show that serum- and glucocorticoid-induced kinase 1 (SGK1) phosphorylates FE65 on serine-610 (S610) and that this phosphorylation attenuates FE65 binding to APP.
Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway.
New
Pearce et al., Tübingen, Germany. In Nephrol Dial Transplant, 09 Aug 2015
ENaC is regulated by the serum- and glucocorticoid-inducible kinase 1 (SGK1), a kinase genomically upregulated by several hormones including glucocorticoids and mineralocorticoids.
PI3K/SGK1/GSK3β signaling pathway Is involved in inhibition of autophagy in neonatal rat cardiomyocytes exposed to hypoxia/reoxygenation by Hydrogen sulfide.
New
Wang et al., Shanghai, China. In Exp Cell Res, 08 Aug 2015
The aim of the present study was to determine whether PI3K/SGK1/GSK3β signaling pathway was involved in the anti-autophagy effect of H2S against myocardial hypoxia/reoxygenation (HR) injury in vitro.
ROLE OF NON-GENOMIC SIGNALLING PATHWAYS ACTIVATED BY ALDOSTERONE DURING CARDIAC REPERFUSION INJURY.
New
Mihailidou et al., Jackson, United States. In Mol Endocrinol, 29 Jul 2015
Aldo-PEG had no effect on MR-dependent transcriptional activation whereas Aldo increased transcript levels of serum-regulated kinase 1 (Sgk-1) and plasminogen activator inhibitor-1 (PAI-1).
Disturbance of oligodendrocyte function plays a key role in the pathogenesis of schizophrenia and major depressive disorder.
Review
New
Tohyama et al., Ōsaka, Japan. In Biomed Res Int, Dec 2014
We have reported that repeated stressful events, one of the major risk factors of MDD, can induce sustained upregulation of plasma corticosterone levels and serum/glucocorticoid regulated kinase 1 (Sgk1) mRNA expression in oligodendrocytes.
Screening of potential target genes for cataract by analyzing mRNA expression profile of mouse Hsf4-null lens.
New
Li et al., Jinan, China. In Bmc Ophthalmol, Dec 2014
Meanwhile, nine GO terms were obtained, and DEGs such as SGK1, CRY2 and REV1 were enriched in response to DNA damage stimulus.
The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.
New
Impact
Powell et al., Baltimore, United States. In Nat Immunol, May 2014
SGK1 is an AGC kinase that regulates the expression of membrane sodium channels in renal tubular cells in a manner dependent on the metabolic checkpoint kinase complex mTORC2.
Relevance of SGK1 in structural, functional and molecular alterations produced by aldosterone in heart.
Review
New
Lahera et al., In Horm Mol Biol Clin Investig, May 2014
SGK1 is a member of the serine/threonine kinase gene family that plays an important role in the absorption of Na+ and water through the Na+ channel in the apical membrane of tubular epithelial cells.
Regulation of transport across cell membranes by the serum- and glucocorticoid-inducible kinase SGK1.
Review
New
Alesutan et al., Tübingen, Germany. In Mol Membr Biol, Feb 2014
The serum- and glucocorticoid-inducible kinase 1 (SGK1) is genomically upregulated by cell stress including energy depletion and hyperosmotic shock as well as a variety of hormones including glucocorticoids, mineralocorticoids and TGFβ.
The sodium chloride cotransporter SLC12A3: new roles in sodium, potassium, and blood pressure regulation.
Review
Hoorn et al., Rotterdam, Netherlands. In Pflugers Arch, 2014
This complex network consists of kinases and ubiquitinases, including WNKs, SGK1, SPAK, Nedd4-2, Cullin-3, and Kelch-like 3. The pathophysiological significance of this network is illustrated by the fact that modification of each individual protein in the network changes NCC activity and results in salt-dependent hypotension or hypertension.
Drug elucidation: invertebrate genetics sheds new light on the molecular targets of CNS drugs.
Review
Buttner et al., Shreveport, United States. In Front Pharmacol, 2013
Similarly, novel targets of antidepressant drugs and lithium have been identified in C. elegans, including lipid-binding/transport proteins and the SGK-1 signaling pathway, respectively.
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1.
Impact
Kuchroo et al., Boston, United States. In Nature, 2013
We identified serum glucocorticoid kinase 1 (SGK1), a serine/threonine kinase, as an essential node downstream of IL-23 signalling.
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Impact
Hafler et al., New Haven, United States. In Nature, 2013
High-salt conditions activate the p38/MAPK pathway involving nuclear factor of activated T cells 5 (NFAT5; also called TONEBP) and serum/glucocorticoid-regulated kinase 1 (SGK1) during cytokine-induced TH17 polarization.
Serum-glucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis.
GeneRIF
Du et al., Beijing, China. In Arterioscler Thromb Vasc Biol, 2012
SGK1 may play an important role in macrophage recruitment and M2 macrophage activation by activating the STAT3 pathway, which leads to angiotensin II-induced cardiac fibrosis.
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.
Impact
Hall et al., Basel, Switzerland. In Cell Metab, 2012
Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates and activates AGC kinase family members, including Akt, SGK1, and PKC, in response to insulin/IGF1.
Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype.
GeneRIF
Staub et al., Lausanne, Switzerland. In Am J Physiol Renal Physiol, 2012
The impaired ability of Sgk1 knockout mice to retain Na+ increased significantly with a low-salt diet despite higher plasma aldosterone levels. On a low-Na+ diet, the Sgk1 knockout mice were also hyperkaliuric and lost body weight.
Serum- and glucocorticoid-dependent kinase-1-induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor.
GeneRIF
Stournaras et al., Tübingen, Germany. In Febs J, 2012
Data show that SGK1 regulates cell migration via vinculin dephosphorylation, a mechanism that is controlled by membrane androgen receptor function.
Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways.
GeneRIF
Park et al., Kwangju, South Korea. In Plos One, 2011
SGK1 is a gamma-secretase regulator presumably effective through phosphorylation and degradation of NCT.
SGK1 sensitivity of platelet migration.
GeneRIF
Lang et al., Tübingen, Germany. In Cell Physiol Biochem, 2011
SGK1 participates in the signaling of platelet migration
Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure.
Impact
GeneRIF
Brosens et al., London, United Kingdom. In Nat Med, 2010
Data show that deregulated SGK1 activity in cycling endometrium interferes with embryo implantation, leading to infertility, or predisposes to pregnancy complications by rendering the feto-maternal interface vulnerable to oxidative damage.
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