Mineralocorticoid and SGK1-Sensitive Inflammation and Tissue Fibrosis.
Tübingen, Germany. In Nephron Physiol, 06 Dec 2014
Mechanisms involved in mineralocorticoid-sensitive inflammation and fibrosis include the serum- and glucocorticoid-inducible kinase 1 (SGK1), which is genomically upregulated by mineralocorticoids and transforming growth factor β (TGF-β), and stimulated by mineralocorticoid-sensitive phosphatidylinositide 3-kinase.
The sodium chloride cotransporter SLC12A3: new roles in sodium, potassium, and blood pressure regulation.
Rotterdam, Netherlands. In Pflugers Arch, Jan 2014
This complex network consists of kinases and ubiquitinases, including WNKs, SGK1, SPAK, Nedd4-2, Cullin-3, and Kelch-like 3. The pathophysiological significance of this network is illustrated by the fact that modification of each individual protein in the network changes NCC activity and results in salt-dependent hypotension or hypertension.
[Function of mTORC2 and its roles in hematological malignancies].
Tianjin, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, Aug 2013
By means of activating AKT, PKCα, SGK1 and so on, the mTORC regulates many vital activities:embryonic development, cytoskeletal reconstitution,cell migration and protein post-translational modification.