Rapid Aldosterone Actions on Epithelial Sodium Channel Trafficking and Cell Proliferation.
Dublin, Ireland. In Steroids, 20 Dec 2013
Aldosterone transcriptionally up-regulates the ENaCα subunit and also up regulates serum and glucocorticoid-regulated kinase-1 (SGK1) that indirectly regulates the ubiquitination of ENaC subunits.. Aldosterone promotes the activation of protein kinase D1 (PKD1) which can modify the activity of ENaC and other transporters through effects on sub-cellular trafficking.
AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases.
Frankfurt am Main, Germany. In Biochim Biophys Acta, Jul 2013
The group of AGC protein kinases includes more than 60 protein kinases in the human genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK, NDR, MAST, YANK, DMPK, GRK and SGK494.
Regulation of Orai1/STIM1 by the kinases SGK1 and AMPK.
Tübingen, Germany. In Cell Calcium, Nov 2012
Phosphorylation of Nedd4-2 by the serum and glucocorticoid inducible kinase SGK1 leads to the binding of Nedd4-2 to the protein 14-3-3 thus preventing its interaction with Orai1.
SGK regulation of renal sodium transport.
Stanford, United States. In Curr Opin Nephrol Hypertens, Sep 2012
OBJECTIVE: The serum and glucocorticoid regulated kinase (SGK) family of protein kinases shares similar biochemical and hormonal signaling properties; however, the SGK kinases also exhibit distinct differences in regulating renal sodium (Na(+)) transport.