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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 10 Nov 2015.

Serum/glucocorticoid regulated kinase 1

This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: Akt, ENaC, V1a, Insulin, CAN
Papers using SGK1 antibodies
Biphasic effects of ANP infusion in conscious, euvolumic rats: roles of AQP2 and ENaC trafficking
Sands Jeff M., In PLoS ONE, 2005
... Antibodies used included anti-actin (Sigma), anti-SGK (serum and glucocorticoid-induced kinase) (Cell Signaling Technology, Beverly, MA) and ...
Papers on SGK1
Serum and glucocorticoid kinase 1 promoted the growth and migration of non-small cell lung cancer cells.
Zhengjian et al., Shanghai, China. In Gene, 06 Dec 2015
UNASSIGNED: Serum and glucocorticoid kinase 1 (SGK1) has been reported to be up-regulated in non-small cell lung cancer (NSCLC).
Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells.
Hafler et al., In J Clin Invest, 02 Dec 2015
The heightened IFNγ secretion and loss of Treg function were mediated by the serum/glucocorticoid-regulated kinase (SGK1).
Enhanced FGF23 production in mice expressing PI3K-insensitive GSK3 is normalized by β-blocker treatment.
Föller et al., Tübingen, Germany. In Faseb J, 02 Dec 2015
UNASSIGNED: Glycogen synthase kinase (GSK)-3 is a ubiquitously expressed kinase inhibited by insulin-dependent Akt/PKB/SGK.
The SIN1-PH Domain Connects mTORC2 to PI3K.
Guan et al., Shanghai, China. In Cancer Discov, 30 Nov 2015
The mTOR complex 2, mTORC2, is a critical downstream effector of PI3K that stimulates AGC kinase members, including AKT, PKC, and SGK.
Riva et al., London, United Kingdom. In J Steroid Biochem Mol Biol, Sep 2015
One gene that lies downstream from GR and may contribute to stress-related changes is serum glucocorticoid kinase-1 (SGK1).
Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway.
Pearce et al., Tübingen, Germany. In Nephrol Dial Transplant, Aug 2015
ENaC is regulated by the serum- and glucocorticoid-inducible kinase 1 (SGK1), a kinase genomically upregulated by several hormones including glucocorticoids and mineralocorticoids.
Sodium chloride, SGK1, and Th17 activation.
Kleinewietfeld et al., Berlin, Germany. In Pflugers Arch, Mar 2015
Recent reports have shown that the differentiation of Th17 cells is sensitive to changes in local microenvironments, in particular salt (NaCl) concentrations, in a molecular mechanism centered around the serum- and glucocorticoid-inducible kinase 1 (SGK1).
Disturbance of oligodendrocyte function plays a key role in the pathogenesis of schizophrenia and major depressive disorder.
Tohyama et al., Ōsaka, Japan. In Biomed Res Int, Dec 2014
We have reported that repeated stressful events, one of the major risk factors of MDD, can induce sustained upregulation of plasma corticosterone levels and serum/glucocorticoid regulated kinase 1 (Sgk1) mRNA expression in oligodendrocytes.
Roles of Akt and SGK1 in the Regulation of Renal Tubular Transport.
Horita et al., Tokyo, Japan. In Biomed Res Int, Dec 2014
Serum- and glucocorticoid-inducible kinase 1 (SGK1) mediates aldosterone signaling.
Excess salt exacerbates blood-brain barrier disruption via a p38/MAPK/SGK1-dependent pathway in permanent cerebral ischemia.
Li et al., Harbin, China. In Sci Rep, Dec 2014
Inhibition of p38/MAPK/SGK1 pathway eliminated the effect of NaCl on BBB permeability in vitro.
The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.
Powell et al., Baltimore, United States. In Nat Immunol, May 2014
SGK1 is an AGC kinase that regulates the expression of membrane sodium channels in renal tubular cells in a manner dependent on the metabolic checkpoint kinase complex mTORC2.
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1.
Kuchroo et al., Boston, United States. In Nature, 2013
We identified serum glucocorticoid kinase 1 (SGK1), a serine/threonine kinase, as an essential node downstream of IL-23 signalling.
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Hafler et al., New Haven, United States. In Nature, 2013
High-salt conditions activate the p38/MAPK pathway involving nuclear factor of activated T cells 5 (NFAT5; also called TONEBP) and serum/glucocorticoid-regulated kinase 1 (SGK1) during cytokine-induced TH17 polarization.
Serum-glucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis.
Du et al., Beijing, China. In Arterioscler Thromb Vasc Biol, 2012
SGK1 may play an important role in macrophage recruitment and M2 macrophage activation by activating the STAT3 pathway, which leads to angiotensin II-induced cardiac fibrosis.
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.
Hall et al., Basel, Switzerland. In Cell Metab, 2012
Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates and activates AGC kinase family members, including Akt, SGK1, and PKC, in response to insulin/IGF1.
Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype.
Staub et al., Lausanne, Switzerland. In Am J Physiol Renal Physiol, 2012
The impaired ability of Sgk1 knockout mice to retain Na+ increased significantly with a low-salt diet despite higher plasma aldosterone levels. On a low-Na+ diet, the Sgk1 knockout mice were also hyperkaliuric and lost body weight.
Serum- and glucocorticoid-dependent kinase-1-induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor.
Stournaras et al., Tübingen, Germany. In Febs J, 2012
Data show that SGK1 regulates cell migration via vinculin dephosphorylation, a mechanism that is controlled by membrane androgen receptor function.
Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways.
Park et al., Kwangju, South Korea. In Plos One, 2011
SGK1 is a gamma-secretase regulator presumably effective through phosphorylation and degradation of NCT.
SGK1 sensitivity of platelet migration.
Lang et al., Tübingen, Germany. In Cell Physiol Biochem, 2011
SGK1 participates in the signaling of platelet migration
Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure.
Brosens et al., London, United Kingdom. In Nat Med, 2010
Data show that deregulated SGK1 activity in cycling endometrium interferes with embryo implantation, leading to infertility, or predisposes to pregnancy complications by rendering the feto-maternal interface vulnerable to oxidative damage.
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