Up-Regulation of FGF23 Release by Aldosterone.
Tübingen, Germany. In Biochem Biophys Res Commun, 07 Feb 2016
The present study explored a putative aldosterone sensitivity of Fgf23 transcription and secretion and the putative involvement of the aldosterone sensitive serum & glucocorticoid inducibe kinase SGK1 and SGK1 sensitive transcription factor NFκB and store operated Ca(2+) entry (SOCE).
Aldosterone Induces Renal Fibrosis and Inflammatory M1-Macrophage Subtype via Mineralocorticoid Receptor in Rats.
Madrid, Spain. In Plos One, 31 Dec 2015
Relative kidney weight, collagen content, fibronectin, macrophage infiltrate, CTGF, Col I, MMP2, TNF-α, CD68, Arg2, and SGK-1 were increased (p<0.05) in aldosterone + salt-treated rats, being reduced by spironolactone (p<0.05).
miRNA and target gene expression in menstrual endometria and early pregnancy decidua.
Hohhot, China. In Eur J Obstet Gynecol Reprod Biol, 27 Dec 2015
METHODS: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to measure the expression of the miR-146b-5p, miR-181b-5p, miR-424, miR-532, miR-199a-3p, miR-423, miR-22-3p, let-7i-5p, and miR-1 and the predicted target genes IGF2R, LEPR, SGK1, MMP2, MMP10, LIF, IL6, and STAT3 in menstrual endometria and early pregnancy decidua.