gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Serum/glucocorticoid regulated kinase 1

SGK1, SGK
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: Akt, V1a, ENaC, Insulin, CAN
Papers using SGK1 antibodies
Biphasic effects of ANP infusion in conscious, euvolumic rats: roles of AQP2 and ENaC trafficking
Supplier
Sands Jeff M., In PLoS ONE, 2005
... Antibodies used included anti-actin (Sigma), anti-SGK (serum and glucocorticoid-induced kinase) (Cell Signaling Technology, Beverly, MA) and ...
Papers on SGK1
(Pro)renin receptor contributes to regulation of renal epithelial sodium channel.
New
Siragy et al., Charlottesville, United States. In J Hypertens, Feb 2016
We hypothesized that PRR plays a role in regulation of renal epithelial sodium channel (ENaC) through serum and glucocorticoid-inducible kinase isoform 1 (SGK-1)-neural precursor cell expressed, developmentally downregulated 4-2 (Nedd4-2) signaling pathway.
Up-Regulation of FGF23 Release by Aldosterone.
New
Lang et al., Tübingen, Germany. In Biochem Biophys Res Commun, Feb 2016
The present study explored a putative aldosterone sensitivity of Fgf23 transcription and secretion and the putative involvement of the aldosterone sensitive serum & glucocorticoid inducibe kinase SGK1 and SGK1 sensitive transcription factor NFκB and store operated Ca(2+) entry (SOCE).
A novel rat model of gestational diabetes induced by intrauterine programming is associated with alterations in placental signaling and fetal overgrowth.
New
Jawerbaum et al., Buenos Aires, Argentina. In Mol Cell Endocrinol, Jan 2016
In this intrauterine programmed GDM model, the placentas showed alterations in mTOR pathway: unchanged phosphorylation of 4EBP-1 and PKCα despite reduced total expression of 4EBP-1 and PKCα, and increased phosphorylation of SGK1.
Aldosterone Induces Renal Fibrosis and Inflammatory M1-Macrophage Subtype via Mineralocorticoid Receptor in Rats.
New
Moreno et al., Madrid, Spain. In Plos One, Dec 2015
Relative kidney weight, collagen content, fibronectin, macrophage infiltrate, CTGF, Col I, MMP2, TNF-α, CD68, Arg2, and SGK-1 were increased (p<0.05) in aldosterone + salt-treated rats, being reduced by spironolactone (p<0.05).
Stress-induced mechanisms in mental illness: A role for glucocorticoid signalling.
Review
New
Riva et al., London, United Kingdom. In J Steroid Biochem Mol Biol, Sep 2015
One gene that lies downstream from GR and may contribute to stress-related changes is serum glucocorticoid kinase-1 (SGK1).
Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway.
Review
New
Pearce et al., Tübingen, Germany. In Nephrol Dial Transplant, Aug 2015
ENaC is regulated by the serum- and glucocorticoid-inducible kinase 1 (SGK1), a kinase genomically upregulated by several hormones including glucocorticoids and mineralocorticoids.
Sodium chloride, SGK1, and Th17 activation.
Review
New
Kleinewietfeld et al., Berlin, Germany. In Pflugers Arch, Mar 2015
Recent reports have shown that the differentiation of Th17 cells is sensitive to changes in local microenvironments, in particular salt (NaCl) concentrations, in a molecular mechanism centered around the serum- and glucocorticoid-inducible kinase 1 (SGK1).
Disturbance of oligodendrocyte function plays a key role in the pathogenesis of schizophrenia and major depressive disorder.
Review
Tohyama et al., Ōsaka, Japan. In Biomed Res Int, 2014
We have reported that repeated stressful events, one of the major risk factors of MDD, can induce sustained upregulation of plasma corticosterone levels and serum/glucocorticoid regulated kinase 1 (Sgk1) mRNA expression in oligodendrocytes.
Roles of Akt and SGK1 in the Regulation of Renal Tubular Transport.
Review
Horita et al., Tokyo, Japan. In Biomed Res Int, 2014
Serum- and glucocorticoid-inducible kinase 1 (SGK1) mediates aldosterone signaling.
High-Salt Enhances the Inflammatory Response by Retina Pigment Epithelium Cells following Lipopolysaccharide Stimulation.
Yang et al., Chongqing, China. In Mediators Inflamm, 2014
Coculture of ARPE-19 cells with NaCl resulted in significant increases in the phosphorylation of p38 MAPK, Akt, and NF-κB and an upregulation of the transcription factors NFAT5 and SGK1.
The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex.
Impact
Powell et al., Baltimore, United States. In Nat Immunol, 2014
SGK1 is an AGC kinase that regulates the expression of membrane sodium channels in renal tubular cells in a manner dependent on the metabolic checkpoint kinase complex mTORC2.
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1.
Impact
Kuchroo et al., Boston, United States. In Nature, 2013
We identified serum glucocorticoid kinase 1 (SGK1), a serine/threonine kinase, as an essential node downstream of IL-23 signalling.
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Impact
Hafler et al., New Haven, United States. In Nature, 2013
High-salt conditions activate the p38/MAPK pathway involving nuclear factor of activated T cells 5 (NFAT5; also called TONEBP) and serum/glucocorticoid-regulated kinase 1 (SGK1) during cytokine-induced TH17 polarization.
Serum-glucocorticoid regulated kinase 1 regulates alternatively activated macrophage polarization contributing to angiotensin II-induced inflammation and cardiac fibrosis.
GeneRIF
Du et al., Beijing, China. In Arterioscler Thromb Vasc Biol, 2012
SGK1 may play an important role in macrophage recruitment and M2 macrophage activation by activating the STAT3 pathway, which leads to angiotensin II-induced cardiac fibrosis.
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.
Impact
Hall et al., Basel, Switzerland. In Cell Metab, 2012
Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates and activates AGC kinase family members, including Akt, SGK1, and PKC, in response to insulin/IGF1.
Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype.
GeneRIF
Staub et al., Lausanne, Switzerland. In Am J Physiol Renal Physiol, 2012
The impaired ability of Sgk1 knockout mice to retain Na+ increased significantly with a low-salt diet despite higher plasma aldosterone levels. On a low-Na+ diet, the Sgk1 knockout mice were also hyperkaliuric and lost body weight.
Serum- and glucocorticoid-dependent kinase-1-induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor.
GeneRIF
Stournaras et al., Tübingen, Germany. In Febs J, 2012
Data show that SGK1 regulates cell migration via vinculin dephosphorylation, a mechanism that is controlled by membrane androgen receptor function.
Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways.
GeneRIF
Park et al., Kwangju, South Korea. In Plos One, 2011
SGK1 is a gamma-secretase regulator presumably effective through phosphorylation and degradation of NCT.
SGK1 sensitivity of platelet migration.
GeneRIF
Lang et al., Tübingen, Germany. In Cell Physiol Biochem, 2011
SGK1 participates in the signaling of platelet migration
Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure.
Impact
GeneRIF
Brosens et al., London, United Kingdom. In Nat Med, 2010
Data show that deregulated SGK1 activity in cycling endometrium interferes with embryo implantation, leading to infertility, or predisposes to pregnancy complications by rendering the feto-maternal interface vulnerable to oxidative damage.
share on facebooktweetadd +1mail to friends