GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Serum/glucocorticoid regulated kinase 1
SGK1, SGK
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009] (from
NCBI)
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Papers using
SGK1
antibodies
Biphasic effects of ANP infusion in conscious, euvolumic rats: roles of AQP2 and ENaC trafficking
Supplier
In PLoS ONE, 2005
Papers on
SGK1
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
New
Impact
New Haven, United States. In Nature, 06 Apr 2013
High-salt conditions activate the p38/MAPK pathway involving nuclear factor of activated T cells 5 (NFAT5; also called TONEBP) and serum/glucocorticoid-regulated kinase 1 (SGK1) during cytokine-induced TH17 polarization.
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1.
New
Impact
Boston, United States. In Nature, 06 Apr 2013
We identified serum glucocorticoid kinase 1 (SGK1), a serine/threonine kinase, as an essential node downstream of IL-23 signalling.
Regulation of forkhead box O1 (FOXO1) by protein kinase B and glucocorticoids: different mechanisms of induction of beta cell death in vitro.
New
Tübingen, Germany. In Diabetologia, 23 Mar 2013
Downregulation of AKT isoforms and serum/glucocorticoid-regulated kinase 1 (SGK1) suggests that only sustained suppression of all three AKT isoforms caused dephosphorylation and nuclear accumulation of FOXO1.
Effects of irbesartan on gene expression revealed by transcriptome analysis of left atrial tissue in a porcine model of acute rapid pacing in vivo.
New
Greifswald, Germany. In Int J Cardiol, 12 Mar 2013
Of special note, the mRNA levels of EDN1, SGK1, and CTGF encoding pro-endothelin, stress- and glucocorticoid activated kinase-1, and of connective tissue growth factor were identified to be significantly increased after 7h of rapid pacing.
The serum- and glucocorticoid- induced protein kinase-1 (Sgk-1) mitochondria connection: Identification of the IF-1 inhibitor of the F(1)F(0)-ATPase as a mitochondria-specific binding target and the stress-induced mitochondrial localization of endogenous Sgk-1.
New
Berkeley, United States. In Biochimie, 08 Mar 2013
The expression, localization and activity of the serum- and glucocorticoid- induced protein kinase, Sgk-1, are regulated by multiple hormonal and environmental cues including cellular stress.
[Effects of astaxanthin on renal fibrosis and cell apoptosis induced by partial unilateral ureteral obstruction in rats].
New
Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, 28 Feb 2013
Renal pathological in the rats was observed with HE staining, and the expression levels of TGF-β1, SGK1, and CTGF in the left kidney were detected immunohistochemically; the expression level of Bcl-2 and Bax were detected using Bcl-2 and Bax detection kits.
Regulation of ion channels by the serum- and glucocorticoid-inducible kinase SGK1.
Review
New
Tübingen, Germany. In Faseb J, Jan 2013
The ubiquitously expressed serum- and glucocorticoid-inducible kinase-1 (SGK1) is genomically regulated by cell stress (including cell shrinkage) and several hormones (including gluco- and mineralocorticoids).
Functional Characterization of Aspergillus nidulans ypkA, a Homologue of the Mammalian Kinase SGK.
New
São Paulo, Brazil. In Plos One, Dec 2012
The serum- and glucocorticoid-regulated protein kinase (SGK) is an AGC kinase involved in signal cascades regulated by glucocorticoid hormones and serum in mammals.
Regulation of Orai1/STIM1 by the kinases SGK1 and AMPK.
Review
New
Tübingen, Germany. In Cell Calcium, Nov 2012
Phosphorylation of Nedd4-2 by the serum and glucocorticoid inducible kinase SGK1 leads to the binding of Nedd4-2 to the protein 14-3-3 thus preventing its interaction with Orai1.
SGK regulation of renal sodium transport.
Review
New
Stanford, United States. In Curr Opin Nephrol Hypertens, Sep 2012
OBJECTIVE: The serum and glucocorticoid regulated kinase (SGK) family of protein kinases shares similar biochemical and hormonal signaling properties; however, the SGK kinases also exhibit distinct differences in regulating renal sodium (Na(+)) transport.
Organization of the ENaC-regulatory machinery.
Review
New
San Francisco, United States. In Crit Rev Biochem Mol Biol, Jul 2012
Na(+) transport in this segment is strongly regulated by the salt-retaining hormone, aldosterone, which acts through the mineralocorticoid receptor (MR) to influence the expression of a selected set of target genes, most notably the serine-threonine kinase SGK1, which phosphorylates and inhibits the E3 ubiquitin ligase Nedd4-2.
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.
New
Impact
Basel, Switzerland. In Cell Metab, Jun 2012
Mammalian target of rapamycin complex 2 (mTORC2) phosphorylates and activates AGC kinase family members, including Akt, SGK1, and PKC, in response to insulin/IGF1.
Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites.
GeneRIF
Stanford, United States. In J Biol Chem, 2011
Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites.
Epithelial sodium channel regulation by cell surface-associated serum- and glucocorticoid-regulated kinase 1.
GeneRIF
Stanford, United States. In J Biol Chem, 2011
the association of sgk1 with the apical cell membrane, where it interacts with ENaC, is a novel means by which sgk1 specifically enhances ENaC activity in aldosterone-stimulated collecting duct cells.
mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel.
GeneRIF
San Francisco, United States. In J Biol Chem, 2011
mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel
SGK1-dependent stimulation of intestinal SGLT1 activity by vitamin D.
GeneRIF
Tübingen, Germany. In Pflugers Arch, 2011
Data show that vitamin D treatment upregulates the expression of SGK1, which in turn enhances SGLT1 activity.
Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer.
Review
Nashville, United States. In Breast Cancer Res, 2010
PI3K activates AKT, serum/glucocorticoid regulated kinase (SGK), phosphoinositide-dependent kinase 1 (PDK1), mammalian target of rapamycin (mTOR), and several other molecules involved in cell cycle progression and survival.
Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure.
Impact
GeneRIF
London, United Kingdom. In Nat Med, 2010
Data show that deregulated SGK1 activity in cycling endometrium interferes with embryo implantation, leading to infertility, or predisposes to pregnancy complications by rendering the feto-maternal interface vulnerable to oxidative damage.
Extensive in vivo metabolite-protein interactions revealed by large-scale systematic analyses.
Impact
Stanford, United States. In Cell, 2010
It is required for the activity of Ypk1, a mammalian AKT/SGK kinase homolog.
