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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ubiquitin-conjugating enzyme E2D 1

SFT, UbcH5a, UbcH5, stimulator of Fe transport
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] (from NCBI)
Top mentioned proteins: Ubiquitin, CAN, CD34, HAD, S-100
Papers on SFT
'Papillary' solitary fibrous tumor/hemangiopericytoma with nuclear STAT6 expression and NAB2-STAT6 fusion.
Sasaki et al., Saitama, Japan. In Brain Tumor Pathol, Feb 2016
UNASSIGNED: This report describes clinicopathological findings, including genetic data of STAT6, in a solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) of the central nervous system in an 83-year-old woman with a bulge in the left forehead.
Solitary fibrous tumor of the breast: report of a case with emphasis on diagnostic role of STAT6 immunostaining.
Palazzo et al., Catania, Italy. In Pathol Res Pract, Jan 2016
UNASSIGNED: We herein report the clinical, radiological, and pathological findings of a rare case of a solitary fibrous tumor (SFT) occurring in the breast parenchyma of a 62-year-old female.
Meningeal Solitary Fibrous Tumors with Delayed Extracranial Metastasis.
Park et al., Seoul, South Korea. In J Pathol Transl Med, Jan 2016
Purpose: The term solitary fibrous tumor (SFT) is preferred over meningeal hemangiopericytoma (HPC), because NAB2-STAT6 gene fusion has been observed in both intracranial and extracranial HPCs.
Characterization of vegetative inflorescence (mc-vin) mutant provides new insight into the role of MACROCALYX in regulating inflorescence development of tomato.
Lozano et al., Almería, Spain. In Sci Rep, Dec 2015
Double combinations between mc-vin and jointless (j) and single flower truss (sft) inflorescence mutants showed that MC has pleiotropic effects on the reproductive phase, and that it interacts with SFT and J to control floral transition and inflorescence fate in tomato.
Solitary fibrous tumors of the prostate: A case report.
Guo et al., Linyi, China. In Oncol Lett, Sep 2015
UNASSIGNED: Increasing numbers of extrapleural solitary fibrous tumours (SFTs), including the prostate SFT, have been reported over the last 10-years.
Ocular adnexal (orbital) solitary fibrous tumor: nuclear STAT6 expression and literature review.
Hamedani et al., Lausanne, Switzerland. In Graefes Arch Clin Exp Ophthalmol, Sep 2015
CONCLUSION: Ocular adnexal SFT are rare and usually present as a chronic orbital mass with proptosis.
Optimization of crop productivity in tomato using induced mutations in the florigen pathway.
Lippman et al., New York City, United States. In Nat Genet, 2014
By screening for chemically induced mutations that suppress the bushy, determinate growth habit of field tomatoes, we isolated a new weak allele of the florigen gene SINGLE FLOWER TRUSS (SFT) and two mutations affecting a bZIP transcription factor component of the 'florigen activation complex' (ref.
Fat-forming solitary fibrous tumor of the kidney: a case report and literature review.
Han et al., Guangzhou, China. In Int J Clin Exp Pathol, 2014
Fat-forming solitary fibrous tumor (SFT) is a rare soft tissue tumor.
Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1.
Dai et al., Portland, United States. In World J Biol Chem, 2014
Instead, it does so by inhibiting the MDM2 cognate ubiquitin-conjugating enzyme (E2) UbcH5.
Hepatic cytochrome P450 ubiquitination: conformational phosphodegrons for E2/E3 recognition?
Guan et al., San Francisco, United States. In Iubmb Life, 2014
Indeed, we have shown that both CYP3A4 and CYP2E1 incur ERAD-C, during which they are first phosphorylated by protein kinases A and C, which greatly enhance/accelerate their ubiquitination by UBC7/gp78 and UbcH5a/CHIP/Hsp70/Hsp40 E2/E3 ubiquitin ligase complexes.
Florigen and anti-florigen - a systemic mechanism for coordinating growth and termination in flowering plants.
Eshed et al., Haifa, Israel. In Front Plant Sci, 2013
Grafting experiments established unequivocal one-to-one relations between SINGLE FLOWER TRUSS (SFT), a tomato homolog of FT, and the hypothetical florigen, in all flowering plants.
Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing.
Chinnaiyan et al., Ann Arbor, United States. In Nat Genet, 2013
A 44-year old woman with recurrent solitary fibrous tumor (SFT)/hemangiopericytoma was enrolled in a clinical sequencing program including whole-exome and transcriptome sequencing.
Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis.
Hay et al., Dundee, United Kingdom. In Nature, 2012
crystal structure of the dimeric RING domain of rat RNF4 in complex with E2 (UbcH5A) linked by an isopeptide bond to ubiquitin
Functional characterization of residues required for the herpes simplex virus 1 E3 ubiquitin ligase ICP0 to interact with the cellular E2 ubiquitin-conjugating enzyme UBE2D1 (UbcH5a).
Boutell et al., Glasgow, United Kingdom. In J Virol, 2012
These data demonstrate that the ability of ICP0 to interact with cellular E2 ubiquitin-conjugating enzyme UBE2D1 is fundamentally important for its biological functions during HSV-1 infection.
The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.
Schwabe et al., Los Angeles, United States. In Genes Dev, 2011
identify the IDOL-UBE2D complex as an important determinant of LDLR activity, and provide insight into molecular mechanisms underlying the regulation of cholesterol uptake
UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.
Klevit et al., Seattle, United States. In Nature, 2011
Structural comparisons of inactive UBCH7-RING complexes with active UBCH5-RING complexes reveal no defining differences, highlighting a gap in our understanding of Ub transfer.
Modulation of K11-linkage formation by variable loop residues within UbcH5A.
Kirkpatrick et al., San Francisco, United States. In J Mol Biol, 2011
This structure reveals an interaction between the ubiquitin surface flanking K11 and residues adjacent to the E2 catalytic cysteine and suggests a possible role for this surface in formation of K11 linkages.
c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.
Vucic et al., San Francisco, United States. In Embo J, 2011
The authors demonstrate that c-IAP1 and UbcH5 family promote K11-linked polyubiquitination of receptor-interacting protein 1 (RIP1) in vitro and in vivo.
Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover.
Eilers et al., Würzburg, Germany. In Nat Cell Biol, 2010
Whereas SCFFbw7 with the Cdc34 ubiquitin-conjugating enzyme specifically requires lysine 48 (K48) of ubiquitin, SCFβ-TrCP uses the UbcH5 ubiquitin-conjugating enzyme to form heterotypic polyubiquitin chains on Myc.
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