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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Secreted frizzled-related protein 5

SFRP5, secreted frizzled-related protein 5
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on SFRP5
Sox2+ stem cells contribute to all epithelial lineages of the tooth via Sfrp5+ progenitors.
GeneRIF
Michon et al., Helsinki, Finland. In Dev Cell, 2012
early progeny of Sox2-positive stem cells transiently expressed the Wnt inhibitor Sfrp5
Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition.
GeneRIF
Macdougald et al., Ann Arbor, United States. In J Clin Invest, 2012
SFRP5 inhibits WNT signaling to suppress oxidative metabolism and stimulate adipocyte growth during obesity.
Pro-inflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects.
GeneRIF
Laudes et al., Kiel, Germany. In Plos One, 2011
Pro-inflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects
Decreased expression and aberrant hypermethylation of the SFRP genes in human gastric cancer.
GeneRIF
Nakao et al., Nagoya, Japan. In Hepatogastroenterology, 2011
significant decrease in the expression of SFRP1 and SFRP5 was observed in gastric cancer compared with corresponding normal gastric tissues
WNT pathway in oral cancer: epigenetic inactivation of WNT-inhibitors.
GeneRIF
Lo Muzio et al., Foggia, Italy. In Oncol Rep, 2010
This study suggests that a cause of catenin delocalization in oral cancer could be due to WNT pathway activation, by epigenetic alterations of SFRP-1, SFRP-2, SFRP-4, SFRP-5, WIF-1, DKK-3 genes
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