MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road.
Cambridge, United Kingdom. In Nat Rev Cancer, Oct 2015
The role of the ERK signalling pathway in cancer is thought to be most prominent in tumours in which mutations in the receptor tyrosine kinases RAS, BRAF, CRAF, MEK1 or MEK2 drive growth factor-independent ERK1 and ERK2 activation and thence inappropriate cell proliferation and survival.
Molecular biology of endometriosis: from aromatase to genomic abnormalities.
Chicago, United States. In Semin Reprod Med, May 2015
Defective CpG methylation affecting several genes that encode key transcription factors such as GATA6, steroidogenic factor-1, and estrogen receptor-β in endometriosis gives rise to overproduction of local estrogen and prostaglandins and suppression of progesterone receptor.