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Sex hormone-binding globulin

Sex Hormone-Binding Globulin, SHBG
This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein binds each steroid molecule as a dimer formed from identical or nearly identical monomers. The use of alternate promoters and alternatively spliced transcripts have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009] (from NCBI)
Top mentioned proteins: AGE, MEN, fibrillin-1, HAD, Insulin
Papers on Sex Hormone-Binding Globulin
Fundamental Frequency of Crying in Two-month-old Boys and Girls: Do Sex Hormones During Mini-puberty Mediate Differences?
Wermke et al., Würzburg, Germany. In J Voice, Feb 2016
The fo properties were correlated to the average serum levels of bioavailable estradiol (E2) (mean E2/sex hormone-binding globulin [SHBG]) and testosterone (T) (mean T/SHBG) across the second month of life.
Sex hormones, sex hormone binding globulin, and vertebral fractures in older men.
Osteoporotic Fractures in Men (MrOS) Study Research Group et al., Stanford, United States. In Bone, Feb 2016
UNASSIGNED: The association between sex hormones and sex hormone binding globin (SHBG) with vertebral fractures in men is not well studied.
An open-label, phase 2, single centre, randomized, crossover design bioequivalence study of AndroForte 5 testosterone cream and Testogel 1% testosterone gel in hypogonadal men: study LP101.
Wlodarczyk et al., Adelaide, Australia. In Andrology, Jan 2016
There were no statistically significant differences between secondary biochemical markers: serum dihydrotestosterone (DHT), oestradiol (E2), sex hormone-binding globulin (SHBG), luteinizing hormone (LH) and (FSH).
A systematic review of GLP-1 agonists on the metabolic syndrome in women with polycystic ovaries.
Nader et al., Tabrīz, Iran. In Arch Gynecol Obstet, Jan 2016
The variables that were examined before and after a 90-day treatment included waist circumference, body mass index (BMI), fasting insulin concentrations, insulin resistance using homeostatic model (HOMA-IR), serum testosterone, and sex hormone-binding globulin (SHBG).
Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men.
de Jongh et al., Amsterdam, Netherlands. In J Steroid Biochem Mol Biol, Dec 2015
Outcome measures were total testosterone, calculated bioavailable and free fraction testosterone, SHBG, estradiol, LH and FSH concentrations.
Human Immunodeficiency Virus Infection and Male Hypogonadism: A Review.
Kietsiriroje, In J Med Assoc Thai, Oct 2015
Considerably more attention should be paid to the diagnosis of hypogonadism in this group particularly because HIV infection increases both sex hormone-binding globulin and total testosterone level.
Sex Hormone Binding Globulin in Children and Adolescents.
Winters et al., In J Clin Res Pediatr Endocrinol, Feb 2015
UNASSIGNED: Sex hormone binding globulin (SHBG) is a circulating glycoprotein that transports testosterone and other steroids in the blood.
Is Immunohistochemical Sex Hormone Binding Globulin Expression Important in the Differential Diagnosis of Adenocarcinomas?
Bayram et al., Van, Turkey. In Asian Pac J Cancer Prev, 2014
This study evaluated the role of sex hormone binding globulin (SHBG) positivity in tumor cells in the subclassification and detection of the original organ of adenocarcinomas.
Sex steroid actions in male bone.
Ohlsson et al., Leuven, Belgium. In Endocr Rev, 2014
Low serum estradiol predicts incident fractures, but the highest risk occurs in men with additionally low T and high SHBG.
Effect of physical activity on sex hormones in women: a systematic review and meta-analysis of randomized controlled trials.
Diorio et al., Québec, Canada. In Breast Cancer Res, 2014
Randomized controlled trials (RCTs) were included if they compared any type of exercise intervention to no intervention or other interventions, and assessed the effects on estrogens, androgens or the sex hormone binding globulin (SHBG) in cancer-free women.
Inclusion of endogenous hormone levels in risk prediction models of postmenopausal breast cancer.
Hankinson et al., Boston, United States. In J Clin Oncol, 2014
Therefore, we evaluated whether inclusion of plasma estradiol, estrone, estrone sulfate, testosterone, dehydroepiandrosterone sulfate, prolactin, and sex hormone-binding globulin (SHBG) improved risk prediction for postmenopausal invasive breast cancer (n = 437 patient cases and n = 775 controls not using postmenopausal hormones) in the Nurses' Health Study.
Sex hormones and risk of breast cancer in premenopausal women: a collaborative reanalysis of individual participant data from seven prospective studies.
Vineis et al., In Lancet Oncol, 2013
METHODS: Individual participant data for prediagnostic sex hormone and sex hormone-binding globulin (SHBG) concentrations were contributed from seven prospective studies.
Association between SHBG Asp327Asn (rs6259) polymorphism and breast cancer risk: a meta-analysis of 10,454 cases and 13,111 controls.
Ma et al., Guangzhou, China. In Mol Biol Rep, 2012
this meta-analysis suggests that SHBG Asp327Asn polymorphism is not associated with breast cancer risk overall, while it might be an important genetic susceptibility factor in postmenopausal Asian women for developing breast cancer.
Reduced-calorie dietary weight loss, exercise, and sex hormones in postmenopausal women: randomized controlled trial.
McTiernan et al., Vancouver, Canada. In J Clin Oncol, 2012
Outcomes were estrone concentration (primary) and estradiol, free estradiol, total testosterone, free testosterone, androstenedione, and sex hormone-binding globulin (SHBG) concentrations (secondary).
Selective cleavage of human sex hormone-binding globulin by kallikrein-related peptidases and effects on androgen action in LNCaP prostate cancer cells.
Harris et al., Brisbane, Australia. In Endocrinology, 2012
ananlysis of selective cleavage of human sex hormone-binding globulin by kallikrein-related peptidases and effects on androgen action in LNCaP prostate cancer cells
Testosterone, SHBG and differential white blood cell count in middle-aged and older men.
Khaw et al., Utrecht, Netherlands. In Maturitas, 2012
Endogenous testosterone and sex-hormone binding globulin levels were inversely associated with total white blood cell and granulocyte count in middle-aged and older men. These results support a link between hormonal status and low-grade inflammation.
Molecular Mechanism of TNFα-Induced Down-Regulation of SHBG Expression.
Selva et al., Barcelona, Spain. In Mol Endocrinol, 2012
Tumor necrosis factor alpha decreases SHBG production by reducing hepatic HNF-4alpha levels via NF-kappaB activation in HepG2 cells.
Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women.
De Vivo et al., Boston, United States. In Plos One, 2011
No variant associated with estradiol, testosterone, or SHBG at P<10(-5) was associated with postmenopausal breast cancer risk.
The role of the urologist in the prevention and early detection of cardiovascular disease.
Gooren et al., Hamburg, Germany. In Arab J Urol, 2011
Lower total testosterone and sex hormone-binding globulin levels predict a higher incidence of the metabolic syndrome.
Testosterone levels and quality of life in diverse male patients with cancers unrelated to androgens.
Suppiah et al., New York City, United States. In J Clin Oncol, 2011
Serum was analyzed for total testosterone (TT), free testosterone (FT), bioavailable testosterone (BAT), and sex hormone binding globulin (SHBG).
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