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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

SET domain, bifurcated 2

SETDB2, SET domain, bifurcated 2, CLLD8
Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: SET, Histone, PHF11, CAN, SETDB1
Papers using SETDB2 antibodies
SMART
Supplier
Kashanchi Fatah et al., In Retrovirology, 1991
... Anti-SETDB2 antibody was purchased from Abgent (San Diego, CA) ...
Papers on SETDB2
Type I Interferon Induced Epigenetic Regulation of Macrophages Suppresses Innate and Adaptive Immunity in Acute Respiratory Viral Infection.
New
Kunkel et al., Nara, Japan. In Plos Pathog, Dec 2015
We have found that type I interferon (IFN-I) potently upregulates the lysine methyltransferase Setdb2 in murine and human Mϕ, and in turn Setdb2 regulates Mϕ-mediated immunity in response to IAV.
Left-Right Axis Differentiation and Functional Lateralization: a Haplotype in the Methyltransferase Encoding Gene SETDB2 Might Mediate Handedness in Healthy Adults.
New
Akkad et al., Bochum, Germany. In Mol Neurobiol, Dec 2015
The methyltransferase SETDB2 (SET domain, bifurcated 2) has been shown to regulate structural left-right asymmetry in the vertebrate central nervous system by suppressing fgf8 expression.
A functional AT/G polymorphism in the 5'-untranslated region of SETDB2 in the IgE locus on human chromosome 13q14.
New
Zhang et al., London, United Kingdom. In Genes Immun, Oct 2015
The immunoglobulin E (IgE)-associated locus on human chromosome 13q14 influencing asthma-related traits contains the genes PHF11 and SETDB2.
Genetic alterations of histone lysine methyltransferases and their significance in breast cancer.
New
Yang et al., Detroit, United States. In Oncotarget, Mar 2015
Integrative analysis identified 8 HMTs (SETDB1, SMYD3, ASH1L, SMYD2, WHSC1L1, SUV420H1, SETDB2, and KMT2C) that are dysregulated by genetic alterations, classifying them as candidate therapeutic targets.
The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection.
Impact
Bergthaler et al., Vienna, Austria. In Nat Immunol, 2015
Here we report that Setdb2 was the only protein lysine methyltransferase induced during infection with influenza virus.
Homozygosity mapping and sequencing identify two genes that might contribute to pointing behavior in hunting dogs.
Epplen et al., Bochum, Germany. In Canine Genet Epidemiol, 2014
In addition, we identified one non-synonomous variation in each of the coding genes SETDB2 and CYSLTR2 that might have a functional consequence.
Epigenetic modulations in activated cells early after HIV-1 infection and their possible functional consequences.
Janini et al., São Paulo, Brazil. In Plos One, 2014
SETDB2 and RSK2 transcripts showed highest up-regulation levels.
Single nucleotide polymorphisms associated with growth traits in Jinghai yellow chickens.
Wang et al., Yangzhou, China. In Genet Mol Res, 2014
The functions of six important candidate genes (SETDB2, ATP7B, INTS6, KPNA3, DLEU7, and FOXO1A) were discussed.
Functional analysis of a novel ENU-induced PHD finger 11 (Phf11) mouse mutant.
Moffatt et al., London, United Kingdom. In Mamm Genome, 2014
After administration of lipopolysaccharide, the level of expression of Il2, NF-kB and Setdb2 were significantly increased in Phf11 mutant homozygous lungs compared to control littermates.
Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1.
Huang et al., Shanghai, China. In Dev Biol, 2014
Here, we show that the setdb2-dvr1 transcriptional cascade plays a critical role in C&E movements during zebrafish gastrulation.
Frameshift mutation of a histone methylation-related gene SETD1B and its regional heterogeneity in gastric and colorectal cancers with high microsatellite instability.
Lee et al., Seoul, South Korea. In Hum Pathol, 2014
The aims of this study were to explore whether SETD1B, SETDB2, and SETD2, SET domain-containing HMT genes, are mutated and expressionally altered in gastric (GC) and colorectal cancers (CRC).
The expanding role of MBD genes in autism: identification of a MECP2 duplication and novel alterations in MBD5, MBD6, and SETDB1.
Gilbert et al., Miami, United States. In Autism Res, 2012
We now describe the first study evaluating individuals with ASD for rare variants in four autosomal MBD family members, MBD5, MBD6, SETDB1, and SETDB2, and expand our initial screening in the MECP2 gene.
13q deletion anatomy and disease progression in patients with chronic lymphocytic leukemia.
Strefford et al., Southampton, United Kingdom. In Leukemia, 2011
Mb), including SETDB2, PHF11 and RCBTB1, was significantly associated (P<0.01) with disease progression.
Identification and expression of potential regulators of the mammalian mitotic-to-meiotic transition.
Griswold et al., Pullman, United States. In Biol Reprod, 2011
Three such candidates include establishment of cohesion 1 homolog 2 (Esco2), encoding a protein essential for sister chromatid cohesion; SET domain, bifurcated 2 (Setdb2), the mouse ortholog of Eggless, which is essential for oogenesis in Drosophila; and ubiquitin-activating enzyme 6 (Uba6), a gene with fivefold higher expression in human and mouse testes than any other organ.
CLLD8/KMT1F is a lysine methyltransferase that is important for chromosome segregation.
GeneRIF
Magdinier et al., Oullins, France. In J Biol Chem, 2010
Results provide evidence that CLLD8/KMT1F is recruited to heterochromatin regions and contributes in vivo to the deposition of trimethyl marks in concert with SUV39H1/KMT1A.SUV39H1/KMT1A.
Asthma severity and genetics in Taiwan.
Review
Huang, Taiwan. In J Microbiol Immunol Infect, 2005
These are A desintegrin and metalloproteinase 33 (ADAM33), dipeptidyl peptidase 10 (DPP10), plant homeodomain zinc finger protein 11 (PHF11) and SET domain, bifurcated 2, G-protein related receptor for asthma (GPRA) and serine protease inhibitor Kazal type 5 (SPINK5).
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