Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells.
Cambridge, United Kingdom. In Nature, Jul 2015
Recent studies have demonstrated that a subset of transposable elements, endogenous retroviral elements (ERVs) containing long terminal repeats (LTRs), are silenced through trimethylation of histone H3 on lysine 9 (H3K9me3) by ESET (also known as SETDB1 or KMT1E) and a co-repressor complex containing KRAB-associated protein 1 (KAP1; also known as TRIM28) in mouse embryonic stem cells.
SETDB1 in Early Embryos and Embryonic Stem Cells.
Taejŏn, South Korea. In Curr Issues Mol Biol, 2014
The histone methyltransferase SETDB1 contributes to the silencing of local chromatin and the target specificity appears to be determined through various proteins that SETDB1 interacts with.
On your histone mark, SET, methylate!
Newcastle, South Africa. In Epigenetics, 2013
Two very interesting examples of this cross-talk between methyl-lysine sites are found in the SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing lysine methyltransferases SET7 and SETDB1, whereby the histone H3 trimethylated on lysine 4 (H3K4 (me3) ) modification prevents methylation by SETDB1 on H3 lysine 9 (H3K9) and the histone H3 trimethylated on lysine 9 (H3K9 (me3) ) modification prevents methylation by SET7 on H3K4.
Dynamics of Setdb1 expression in early mouse development.
Taejŏn, South Korea. In Gene Expr Patterns, 2012
Observations highlight the significance of Setdb1 in early mouse development; Setdb1 signals were observed diffusely in the nucleus from the two-cell stage onward and, by the blastocyst, took a punctate form, away from nucleolus.
Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis.
Tokyo, Japan. In Nat Rev Rheumatol, 2009
Signaling via the canonical Wnt-beta-catenin pathway inhibits PPARgamma mRNA expression, whereas signaling via the noncanonical Wnt pathway results in activation of a histone methyltransferase SETDB1 that represses PPARgamma transactivation through histone H3K9 methylation of target genes.