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Sestrin 2

Sestrin2, Sesn2, Hi95, H195, Ses2
This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p53, Ros, V1a, AMPK, mTOR
Papers on Sestrin2
Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4.
Evstafieva et al., Moscow, Russia. In Cell Cycle, Feb 2016
We found that inhibitors of mitochondrial respiratory chain complexes III (myxothiazol) and I (piericidin A) in some epithelial carcinoma cell lines induce transcription of the p53-responsive SESN2 gene that plays an important role in stress response and homeostatic regulation.
p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb.
Moran et al., Richmond, United States. In Mol Cancer Res, Jan 2016
Mechanistically, it was determined that loss or mutation of p53 decreased expression of TSC2 and Sestrin2 (SESN2).
Nck1 deficiency improves pancreatic β cell survival to diabetes-relevant stresses by modulating PERK activation and signaling.
Larose et al., Montréal, Canada. In Cell Signal, Dec 2015
Interestingly, silencing Nck1 in MIN6 cells results in increased PERK basal activity and expression of the PERK downstream target sestrin2, which promotes autophagy by attenuating mTORC1 activation through AMPK-dependent and -independent mechanisms.
Actinomycin D and nutlin-3a synergistically promote phosphorylation of p53 on serine 46 in cancer cell lines of different origin.
Rusin et al., Gliwice, Poland. In Cell Signal, Sep 2015
Other p53 target genes (SESN1, SESN2, TIGAR, DRAM1) were also efficiently upregulated; however, a marker of apoptosis (active caspase-3) appeared only in some cancer cell lines (e.g., A375 and other cell lines derived from melanoma) indicating that phosphorylation of p53 on serine 46 is not straightforwardly associated with induction of apoptosis.
Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.
Qin et al., Suzhou, China. In Mol Cell Biol, Aug 2015
In the present study, we investigated the role of sestrin2 in autophagic degradation of α-synuclein and preservation of cell viability in a rotenone-induced cellular model of PD.
Toward the development of transcriptional biodosimetry for the identification of irradiated individuals and assessment of absorbed radiation dose.
Kruszewski et al., Warsaw, Poland. In Radiat Environ Biophys, Aug 2015
The mRNA level of 16 genes (ATF3, BAX, BBC3, BCL2, CDKN1A, DDB2, FDXR, GADD45A, GDF15, MDM2, PLK3, SERPINE1, SESN2, TNFRSF10B, TNFSF4, and VWCE) was assessed by reverse transcription quantitative PCR 6, 12, 24, and 48 h after exposure with ITFG1 and DPM1 used as a reference genes.
Nuclear Factor-kappaB-Dependent Sestrin2 Induction Mediates the Antioxidant Effects of BDNF Against Mitochondrial Inhibition in Rat Cortical Neurons.
Yang et al., Taipei, Taiwan. In Mol Neurobiol, Aug 2015
Sestrin2 is a stress-responsive gene implicated in the cellular defense against oxidative stress.
Gossypol Acetic Acid Prevents Oxidative Stress-Induced Retinal Pigment Epithelial Necrosis by Regulating the FoxO3/Sestrin2 Pathway.
Wang et al., New Orleans, United States. In Mol Cell Biol, Jul 2015
Sestrin2 (SESN2) is found to mediate GAA function in antioxidative response and RPE survival upon oxidative stress.
[Study of thioredoxin antioxidative system in lateral geniculate body of chronic intraocular hypertension rat].
Sun et al., Shanghai, China. In Zhonghua Yan Ke Za Zhi, Feb 2015
The expression of Trx, Trx1, Trx2, Sesn2, Srxn1, Txnip was detected by Western blot and RT-PCR at different time points after intraocular pressure rose (1, 3, 7, 14, 28 d), and were grouped according to the time points.
Insulin Increases Sestrin 2 Content by Reducing Its Degradation through the PI 3 K/mTOR Signaling Pathway.
Yu et al., Fuzhou, China. In Int J Endocrinol, 2014
Here we report that insulin markedly increased SESN2 level in HepG2 cells through mTOR activation.
Roles of Sestrin2 and Ribosomal Protein S6 in Transient Global Ischemia-Induced Hippocampal Neuronal Injury.
Chen et al., Kao-hsiung, Taiwan. In Int J Mol Sci, 2014
Recent studies suggested that sestrin2 is a crucial modulator for the production of reactive oxygen species (ROS).
Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm.
Wang et al., Shenzhen, China. In Cell, 2012
We further identified essential thrombocythemia (ET)-related candidate mutations such as SESN2 and NTRK1, which may be involved in neoplasm progression.
Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.
Singh et al., Hamilton, Canada. In Plos One, 2011
In breast cancer cells SESN2 is associated with AMPK.
Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells.
Feng et al., Hong Kong, Hong Kong. In Br J Pharmacol, 2011
Signalling by the AMP-activated protein kinase was also involved as a downstream target of sestrin2.
Association of platelet-derived growth factor receptor β accumulation with increased oxidative stress and cellular injury in sestrin 2 silenced human glioblastoma cells.
Lee et al., Taipei, Taiwan. In Febs Lett, 2011
PDGFRbeta accumulation is associated with increased oxidative stress and cellular damage in SESN2 silenced human glioblastoma U87 cells.
Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.
von Melchner et al., Frankfurt am Main, Germany. In Dis Model Mech, 2010
The mutational inactivation of the antioxidant protein sestrin 2 (sesn2) partially rescues the emphysema phenotype of Ltbp4S mice and is associated with activation of the TGF-beta and mammalian target of rapamycin (mTOR) signal transduction pathways.
Role of sestrin2 in peroxide signaling in macrophages.
Brüne et al., Frankfurt am Main, Germany. In Febs Lett, 2009
Sestrin2 plays a role in peroxide defense as a reductase for peroxiredoxins.
p53 strikes mTORC1 by employing sestrins.
Hay, Chicago, United States. In Cell Metab, 2008
Recent results by Budanov and Karin, (2008) reveal that p53 exerts its effect on mTORC1 through sestrin1 and sestrin2.
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.
Karin et al., San Diego, United States. In Cell, 2008
Sestrin1 and Sestrin2 therefore provide an important link between genotoxic stress, p53 and the mTOR signaling pathway.
Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.
Chumakov et al., Cleveland, United States. In Science, 2004
results show that sestrins, a family of proteins whose expression is modulated by p53, are required for regeneration of peroxiredoxins containing Cys-SO(2)H
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