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Serum amyloid A1

serum amyloid A, SAA1
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn s disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: HAD, Interleukin-6, C-reactive protein, CAN, Haptoglobin
Papers on serum amyloid A
Serum acute phase proteins in Dirofilaria immitis and Wolbachia seropositive cats.
Pastor et al., Vila Real, Portugal. In J Feline Med Surg, Feb 2016
METHODS: The APP serum amyloid A (SAA), haptoglobin (Hp) and ceruloplasmin (Cp) were measured in 25 seropositive cats and in 16 healthy seronegative cats.
Effect of Arthroscopic Lavage on Systemic and Synovial Fluid Serum Amyloid A in Healthy Horses.
Rubio-Martínez et al., Saskatoon, Canada. In Vet Surg, Feb 2016
OBJECTIVE: To evaluate the effect of arthroscopic lavage on systemic serum amyloid A (SAA) and SAA, total protein, nucleated cell count, and percentage of neutrophils in synovial fluid in healthy horses.
Effect of vitamin B12 and folic acid supplementation on biomarkers of endothelial function and inflammation among elderly individuals with hyperhomocysteinemia.
Smulders et al., Rotterdam, Netherlands. In Vasc Med, Feb 2016
Using an electrochemiluminescence platform, we measured intercellular adhesion molecule 1 (ICAM-1), vascular adhesion molecule 1 (VCAM-1), serum amyloid A (SAA), vascular endothelial growth factor (VEGF) and C-reactive protein (CRP) at baseline and follow-up in a subsample of 522 participants (271 intervention group; 251 placebo).
Designing peptidic inhibitors of serum amyloid A aggregation process.
Jankowska et al., Gdańsk, Poland. In Amino Acids, Feb 2016
It is characterized by extracellular tissue deposition of fibrils that are composed of fragments of serum amyloid A protein (SAA), a major acute-phase reactant protein, produced predominantly by hepatocytes.
Serum Amyloid A Induces Toll-Like Receptor 2-Dependent Inflammatory Cytokine Expression and Atrophy in C2C12 Skeletal Muscle Myotubes.
Hansen et al., Melbourne, Australia. In Plos One, Dec 2015
Serum levels of the pro-inflammatory acute phase protein Serum Amyloid A (SAA) can rise more than 1000-fold in AECOPD and are predictively correlated with exacerbation severity.
An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses.
Littman et al., New York City, United States. In Cell, Nov 2015
However, robust IL-17A production was restricted to the ileum, where SFB makes direct contact with the epithelium and induces serum amyloid A proteins 1 and 2 (SAA1/2), which promote local IL-17A expression in RORγt(+) T cells.
Renal LECT2 amyloidosis: a newly described disorder gaining greater recognition.
Lerma et al., In Clin Nephrol, Oct 2015
Most often, the deposition is composed of the well-known monoclonal immunoglobulin light chains (AL) or serum amyloid A protein (AA).
Serum Amyloid A-Positive Hepatocellular Neoplasm: A New Type of Tumor Arising in Patients with Advanced Alcoholic Disease.
Nakanuma et al., Kanazawa, Japan. In Dig Dis, Sep 2015
This chapter reviews a new type of hepatocellular neoplasm, serum amyloid A-positive hepatocellular neoplasm (SAA-HN), which arises in patients with advanced alcoholic liver disease such as cirrhosis.
Markers of preclinical atherosclerosis and their clinical relevance.
Kaja Ježovnik et al., Ljubljana, Slovenia. In Vasa, Jul 2015
Increased basal levels of cytokines, the cell adhesion molecules, selectins and acute-phase reactants such as high sensitive C-reactive protein (hsCRP), fibrinogen, and serum amyloid A are related to an increased risk of cardiovascular events.
AA amyloidosis: pathogenesis and targeted therapy.
Westermark et al., Uppsala, Sweden. In Annu Rev Pathol, 2014
In AA amyloidosis, the expression of cytokines, particularly interleukin 6, leads to overproduction of serum amyloid A (SAA) by the liver.
Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights.
Gursky et al., Boston, United States. In Adv Exp Med Biol, 2014
Misfolding of apoA-I, apoA-II, and serum amyloid A (SAA) causes systemic amyloidoses, apoE4 is a critical risk factor in Alzheimer's disease, and apolipoprotein misfolding is also implicated in cardiovascular disease.
Intrinsic Stability, Oligomerization, and Amyloidogenicity of HDL-Free Serum Amyloid A.
Srinivasan et al., Troy, United States. In Adv Exp Med Biol, 2014
Serum amyloid A (SAA) is an acute-phase reactant protein predominantly bound to high-density lipoprotein in serum and presumed to play various biological and pathological roles.
Fatigue, inflammation, and ω-3 and ω-6 fatty acid intake among breast cancer survivors.
Ballard-Barbash et al., Bethesda, United States. In J Clin Oncol, 2012
METHODS: Six hundred thirty-three survivors (mean age, 56 years; stage I to IIIA) participating in the Health, Eating, Activity, and Lifestyle Study completed a food frequency/dietary supplement questionnaire and provided a blood sample assayed for C-reactive protein (CRP) and serum amyloid A (30 months after diagnosis) and completed the Piper Fatigue Scale and Short Form-36 (SF-36) vitality scale (39 months after diagnosis).
Large-scale isotype-specific quantification of Serum amyloid A 1/2 by multiple reaction monitoring in crude sera.
Cho et al., Seoul, South Korea. In J Proteomics, 2012
successful quantification of SAA2 in crude serum by MRM, for the first time, shows that SAA2 can be a good biomarker for the detection of lung cancers.
Acute-phase serum amyloid A regulates tumor necrosis factor α and matrix turnover and predicts disease progression in patients with inflammatory arthritis before and after biologic therapy.
Fearon et al., Dublin, Ireland. In Arthritis Rheum, 2012
acute phase SAA may be involved in joint destruction though MMP induction and collagen cleavage in vivo.
Purification, identification and profiling of serum amyloid A proteins from sera of advanced-stage cancer patients.
Yang et al., Beijing, China. In J Chromatogr B Analyt Technol Biomed Life Sci, 2012
Purified ten targeted proteins from sera of patients with various types of advanced stage(stage III-IV)cancers. These proteins were identified as isoforms of the human serum amyloid protein A (SAA) family with or without truncations at their N-terminals.
AA amyloid quantification in biopsy samples from the stomach.
Okuda et al., Tochigi, Japan. In Ann Clin Lab Sci, 2011
Amyloid A (AA) proteins in biopsy samples taken from the stomachs of patients with AA amyloidosis
Amyloid A amyloidosis secondary to rheumatoid arthritis: pathophysiology and treatments.
Nakamura, Kumamoto, Japan. In Clin Exp Rheumatol, 2011
Reactive amyloid A (AA) amyloidosis, one of the most severe complications of RA, is a serious, potentially life-threatening disorder caused by deposition of AA amyloid fibrils in multiple organs.
Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A.
Cerundolo et al., Oxford, United Kingdom. In Nat Immunol, 2010
We now show that systemic serum amyloid A 1 (SAA-1) controls the plasticity of neutrophil differentiation.
Use of canakinumab in the cryopyrin-associated periodic syndrome.
Canakinumab in CAPS Study Group et al., London, United Kingdom. In N Engl J Med, 2009
We evaluated therapeutic responses using disease-activity scores and analysis of levels of C-reactive protein (CRP) and serum amyloid A protein (SAA).
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