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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Tousled-like kinase 1

serine-threonine protein kinase, TLK1
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: Akt, CAN, ACID, V1a, HAD
Papers on serine-threonine protein kinase
Atrial remodeling in atrial fibrillation: CaMKII as a nodal proarrhythmic signal.
Anderson et al., Baltimore, United States. In Cardiovasc Res, Feb 2016
UNASSIGNED: CaMKII is a serine-threonine protein kinase that is abundant in myocardium.
First report of somatic mosaicism for mutations in STK11 in four patients with Peutz-Jeghers syndrome.
Greenhalgh et al., Liverpool, United Kingdom. In Fam Cancer, Jan 2016
Mutations in STK11, a serine-threonine protein kinase, have been associated with PJS in up to 100 % of published series.
Hypoxic stress: impact on the modulation of TLR2, TLR4, NOD1 and NOD2 receptor and their down-stream signalling genes expression in catla (Catla catla).
Samanta et al., Bhubaneshwar, India. In Mol Biol Rep, Jan 2016
After the designated time course, total RNA was extracted from gill, liver, kidney and blood, and modulation of TLRs (TLR2 and TLR4), NOD (NOD1 and NOD2) receptors, MyD88 (myeloid differentiation primary response gene 88), RICK (receptor interacting serine-threonine protein kinase-2), interleukin (IL)-6, IL-8 and IL-10 gene expression were analyzed by quantitative reverse transcriptase PCR assay.
mTOR signaling controls VGLUT2 expression to maintain pain hypersensitivity after tissue injury.
Amaya et al., Kyoto, Japan. In Neuroscience, Dec 2015
Mammalian target of rapamycin (mTOR) is a serine-threonine protein kinase that controls protein synthesis in the nervous system.
Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.
Oegema et al., San Diego, United States. In Science, Jul 2015
To investigate the importance of centrosomes in the proliferation of normal and cancer cells, we developed centrinone, a reversible inhibitor of Polo-like kinase 4 (Plk4), a serine-threonine protein kinase that initiates centriole assembly.
Activation of the Mammalian Target of Rapamycin in the Rostral Ventromedial Medulla Contributes to the Maintenance of Nerve Injury-Induced Neuropathic Pain in Rat.
Li et al., Xi'an, China. In Neural Plast, 2014
The mammalian target of rapamycin (mTOR), a serine-threonine protein kinase, integrates extracellular signals, thereby modulating several physiological and pathological processes, including pain.
Effects of doxepin on brain-derived neurotrophic factor, tumor necrosis factor alpha, mitogen-activated protein kinase 14, and AKT1 genes expression in rat hippocampus.
Reisi et al., Eşfahān, Iran. In Adv Biomed Res, 2014
Therefore, this study investigated the effect of doxepin on gene expression of brain-derived neurotrophic factor (BDNF), tumor necrosis factor alpha (TNF-α), mitogen-activated protein kinase 14 (MAPK14), and serine-threonine protein kinase AKT1 in rat hippocampus.
Molecular biomarkers and classification models in the evaluation of the prognosis of colorectal cancer.
Papagrigoriadis et al., London, United Kingdom. In Anticancer Res, 2014
CIMP is the third most commonly involved event, and is defined by widespread methylation of CpG islands of suppressor promoters, with two phenotypes: CIMP-high and CIMP-low which interact with MSI or CIN status V-raf murine sarcoma viral oncogene homolog B (BRAF) is a serine-threonine protein kinase that acts as a downstream effector of the Kirsten rat sarcoma viral oncogene homolog (KRAS) pathway.
Costimulatory molecule DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse cytomegalovirus infection.
Lanier et al., San Francisco, United States. In Immunity, 2014
Src-family tyrosine kinase Fyn and serine-threonine protein kinase C isoform eta (PKCη) signaling through DNAM-1 played distinct roles in the generation of MCMV-specific effector and memory NK cells.
BRAF mutations in melanoma and colorectal cancer: a single oncogenic mutation with different tumour phenotypes and clinical implications.
Crown et al., Dublin, Ireland. In Crit Rev Oncol Hematol, 2013
BRAF is an oncogene encoding a serine-threonine protein kinase involved in the MAPK signalling cascade.
Improved survival with MEK inhibition in BRAF-mutated melanoma.
METRIC Study Group et al., Boston, United States. In N Engl J Med, 2012
BACKGROUND: Activating mutations in serine-threonine protein kinase B-RAF (BRAF) are found in 50% of patients with advanced melanoma.
Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice.
Podrez et al., Cleveland, United States. In Cell Metab, 2012
Akt, a serine-threonine protein kinase, exists as three isoforms.
Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib.
Ribas et al., Nashville, United States. In N Engl J Med, 2012
BACKGROUND: Approximately 50% of melanomas harbor activating (V600) mutations in the serine-threonine protein kinase B-RAF (BRAF).
A pseudokinase debut at the mycobacterial cell wall.
Mizrahi et al., Cape Town, South Africa. In Sci Signal, 2012
New findings implicate the essential mycobacterial serine-threonine protein kinase (STPK), PknB, in regulating the formation of a regulatory complex that includes the integral membrane protein MviN, which is required for peptidoglycan biosynthesis, and a forkhead-associated (FHA) domain protein, FhaA.
Role of BRAF in thyroid oncogenesis.
Shah et al., Columbus, United States. In Clin Cancer Res, 2012
BRAF, a cytoplasmic serine-threonine protein kinase, plays a critical role in cell signaling as an activator within the mitogen-activated protein kinase (MAPK) pathway.
The expression of Tousled kinases in CaP cell lines and its relation to radiation response and DSB repair.
De Benedetti et al., Shreveport, United States. In Prostate, 2011
TLKs appear to be intimately linked to the pattern of resistance to DNA damage, and specifically double-strand breaks.
Adenoviral delivery of Tousled kinase for the protection of salivary glands against ionizing radiation damage.
Sunavala-Dossabhoy et al., Shreveport, United States. In Gene Ther, 2011
Adenoviral delivery of Tousled kinase protects salivary glands against ionizing radiation damage.
Silencing of Tousled-like kinase 1 sensitizes cholangiocarcinoma cells to cisplatin-induced apoptosis.
Senga et al., Nagoya, Japan. In Cancer Lett, 2010
Silencing of TLK1 enhanced DNA damage induced by cisplatin treatment, suggesting that TLK1 plays a pivotal role for the repair of cisplatin-induced DNA damage.
Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases.
Moshkin et al., Genève, Switzerland. In Plos One, 2008
ASF1 cellular levels are tightly controlled by distinct pathways and provide a molecular mechanism for post-translational regulation of dASF1 and hASF1a by TLK kinases.
TLK1B promotes repair of DSBs via its interaction with Rad9 and Asf1.
De Benedetti et al., Shreveport, United States. In Bmc Mol Biol, 2008
present direct evidence that TLK1B can promote repair of linearized plasmids with incompatible ends that require processing prior to ligation.
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