gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ATPase, Ca++ transporting, ubiquitous

SERCA3, sarco/endoplasmic reticulum Ca2+-ATPase, ATP2A3
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ATPase, SERCA, SERCA2, SR Ca(2+)-ATPase, ACID
Papers on SERCA3
Histone deacetylase inhibitors promote the expression of ATP2A3 gene in breast cancer cell lines.
New
Santiago-García et al., Veracruz, Mexico. In Mol Carcinog, Oct 2015
The ATP2A2 and ATP2A3 genes encode SERCA2 and SERCA3 isoforms, respectively.
Isoflavones in soy flour diet have different effects on whole-genome expression patterns than purified isoflavone mix in human MCF-7 breast tumors in ovariectomized athymic nude mice.
New
Helferich et al., Champaign, United States. In Mol Nutr Food Res, Aug 2015
Tumors in MS-fed mice exhibited higher expression of tumor growth suppressing genes ATP2A3 and BLNK and lower expression of oncogene MYC.
Inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA1) by rutin derivatives.
New
Horakova et al., Bratislava, Slovakia. In J Muscle Res Cell Motil, Apr 2015
The effect of lipophilic rutin derivatives (acylated with fatty acid chain length of 16-22) on sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA1 isoform) compared to the parent molecule rutin was evaluated.
Quantitative proteomics reveals ELP2 as a regulator to the inhibitory effect of TNF-α on osteoblast differentiation.
New
Yu et al., Guangzhou, China. In J Proteomics, Mar 2015
The results showed 6 proteins involved in BMP-2 induced osteoblast differentiation inhibition by TNF-α: Periostin, Protein S100-A4, ATPase inhibitor, Cytochrome b5, SERCA3, and ELP2.
Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs.
New
Li et al., Hong Kong, Hong Kong. In Circ Arrhythm Electrophysiol, Feb 2015
As anticipated from the inhibitory effect of unphosphorylated PLB on sarco/endoplasmic reticulum Ca2+-ATPase, Ad-PLB transduction significantly attenuated electrically evoked Ca2+ transient amplitude and prolonged the 50% decay time.
mir-233 modulates the unfolded protein response in C. elegans during Pseudomonas aeruginosa infection.
Zhang et al., Kunming, China. In Plos Pathog, 2015
Quantitative proteomic analysis identifies SCA-1, a C. elegans homologue of the sarco/endoplasmic reticulum Ca2+-ATPase, as a target of mir-233.
Enhanced Store-Operated Calcium Entry in Platelets is Associated with Peripheral Artery Disease in Type 2 Diabetes.
Zhao et al., In Cell Physiol Biochem, 2014
Platelet calcium influx and protein expression of STIM1 and sarcoendoplasmic reticulum Ca2+-ATPase 3 (SERCA3) were investigated.
Polymorphisms in Ion Transport Genes Are Associated with Eggshell Mechanical Property.
Yang et al., Beijing, China. In Plos One, 2014
Both ATP2A3 and SLC4A5 had a significant effect on all the three traits.
Regulation of SERCA pumps expression in diabetes.
Review
Estrada-Avilés et al., Mexico. In Cell Calcium, 2014
In the diabetic pancreas, there has been reported reduction in SERCA2b and SERCA3 expression in β-cells, resulting in diminished insulin secretion.
Regulation of PKC mediated signaling by calcium during visceral leishmaniasis.
Sen et al., Calcutta, India. In Plos One, 2013
In the present study we have dileneated the involvement of PMCA4 and SERCA3 during leishmaniasis.
A systematic review of fetal genes as biomarkers of cardiac hypertrophy in rodent models of diabetes.
Review
Marsh et al., Spokane, United States. In Plos One, 2013
There were no correlations between the heart weight:body weight index and mRNA or protein levels of the fetal genes α-myosin heavy chain (α-MHC) or β-MHC, sarco/endoplasmic reticulum Ca2+-ATPase, atrial natriuretic peptide (ANP), or brain natriuretic peptide.
Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.
Impact
Brown et al., Cambridge, United Kingdom. In Nat Genet, 2013
Gain-of-function mutations in KCNJ5 and apparent loss-of-function mutations in ATP1A1 and ATP2A3 were reported to occur in APAs.
Mechanisms of control of the free Ca2+ concentration in the endoplasmic reticulum of mouse pancreatic β-cells: interplay with cell metabolism and [Ca2+]c and role of SERCA2b and SERCA3.
GeneRIF
Gilon et al., Brussels, Belgium. In Diabetes, 2011
This study evaluated the role of SERCA2b and SERCA3 in the control of the free calcium concentration in the endoplasmic reticulum and the role of SERCA3 in the control of insulin secretion.
Endoplasmic reticulum calcium pumps and cancer.
Review
Papp et al., Paris, France. In Biofactors, 2011
In several cell types such as cells of hematopoietic origin or various epithelial cells, two SERCA genes (SERCA2 and SERCA3) are simultaneously expressed.
Markers of squamous cell carcinoma in sarco/endoplasmic reticulum Ca2+ ATPase 2 heterozygote mice keratinocytes.
Review
Shin et al., Seoul, South Korea. In Prog Biophys Mol Biol, 2010
A mutation of Atp2a2 gene encoding the sarco/endoplasmic reticulum Ca(2+)-ATPase 2 (SERCA2) causes Darier's disease in human and null mutation in one copy of Atp2a2 leads to a high incidence of squamous cell tumor in a mouse model.
Multiple and diverse coexpression, location, and regulation of additional SERCA2 and SERCA3 isoforms in nonfailing and failing human heart.
Review
GeneRIF
Enouf et al., Paris, France. In J Mol Cell Cardiol, 2010
SERCA2 and SERCA3 isoforms have roles in the failing and failing human heart
Determination of apparent calcium affinity for endogenously expressed human sarco(endo)plasmic reticulum calcium-ATPase isoform SERCA3.
GeneRIF
Lytton et al., Calgary, Canada. In Am J Physiol Cell Physiol, 2009
affinity for Ca(2+) is inherently lower for SERCA3 expressed in situ than for other SERCA isoforms
Expression of sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) 3 proteins in two major conformational states in native human cell membranes.
GeneRIF
Enouf et al., Paris, France. In Biochim Biophys Acta, 2009
two distinct SERCA3 fragmentation profiles sign the co-expression of SERCA3 proteins in two conformational states in platelet membranes.
Modulation of B-cell endoplasmic reticulum calcium homeostasis by Epstein-Barr virus latent membrane protein-1.
GeneRIF
Papp et al., Paris, France. In Mol Cancer, 2008
Data show that low Ca2+-affinity SERCA3, and the high Ca2+-affinity SERCA2 enzymes are simultaneously expressed in B cells, and decreased SERCA3 expression during EBV-infection.
share on facebooktweetadd +1mail to friends