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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Jagged 2

Ser2, Jagged2, JAG2
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: p300, Notch3, CAN, HAD, Notch2
Papers using Ser2 antibodies
The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo
Supplier
Griffin J D et al., In British Journal of Cancer, 2006
... Jagged2 antibody was from Cell Signaling (Danvers, MA, USA) ...
Papers on Ser2
A multicentric association study between 39 genes and nonsyndromic cleft lip and palate in a Brazilian population.
New
Gil-da-Silva-Lopes et al., Campinas, Brazil. In J Craniomaxillofac Surg, Jan 2016
RESULTS: Twenty-four SNPs in 16 genes were significantly associated with the etiology of NSCLP, including MSX1, SPRY1, MSX2, PRSS35, TFAP2A, SHH, VAX1, TBX10, WNT11, PAX9, BMP4, JAG2, AXIN2, DVL2, KIF7, and TCBE3.
Aberrant expression of Notch1, HES1, and DTX1 genes in glioblastoma formalin-fixed paraffin-embedded tissues.
New
Chand et al., Bengaluru, India. In Tumour Biol, Jan 2016
Using real-time PCR, we assessed the expression of Notch genes including receptors (Notch1, Notch2, Notch3, and Notch4), ligands (JAG1, JAG2, and DLL3), downstream targets (HES1 and HEY2), regulator Deltex1 (DTX1), inhibitor NUMB along with transcriptional co-activator MAML1, and a component of gamma-secretase complex APH1A in 15 formalin-fixed paraffin-embedded (FFPE) patient samples.
Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung.
New
Impact
Siebel et al., San Francisco, United States. In Nature, Jan 2016
During development or repair, the closely related Jagged ligands (JAG1 and JAG2) induce Notch signalling to determine the fate of these lineages as they descend from a common proliferating progenitor.
Breast parenchymal signal enhancement ratio at preoperative magnetic resonance imaging: association with early recurrence in triple-negative breast cancer patients.
New
Moon et al., Seoul, South Korea. In Acta Radiol, Nov 2015
At multivariate analysis of preoperative variables, a higher SER around the tumor was independently associated with worse recurrence-free survival (hazard ratio [HR] = 7.072, P = 0.003 for SER1; HR = 6.268, P = 0.006 for SER2; HR = 3.004, P = 0.039 for SER3).
A 10-gene expression signature of Notch pathway predicts recurrence in ovarian carcinoma.
New
Liu et al., Weifang, China. In Oncol Lett, Sep 2015
A 10-gene signature (FZD4, HES1, PSEN2, JAG2, PPARG, FOS, HEY1, CDC16, MFNG, and EP300) was identified and validated that is associated with recurrence-free survival time, but not with overall survival time, in the TCGA dataset and in other two independent datasets, GSE9891 and GSE30161.
Combined QTL and selective sweep mappings with coding SNP annotation and cis-eQTL analysis revealed PARK2 and JAG2 as new candidate genes for adiposity regulation.
New
Lagarrigue et al., Rennes, France. In G3 (bethesda), Apr 2015
Moreover, it highlights two genes, JAG2 and PARK2, as new potential negative and positive key regulators of adiposity in chicken and mice.
Supination external rotation ankle fractures: A simpler pattern with better outcomes.
New
Egol et al., New York City, United States. In Indian J Orthop, Mar 2015
This study reports the functional outcomes following a stable, low energy, rotational ankle fracture supination external rotation (SER2) when compared to unstable SER4 fractures treated operatively.
Downregulation of notch signaling pathway in late preterm and term placentas from pregnancies complicated by preeclampsia.
Spandidos et al., Irákleion, Greece. In Plos One, 2014
On the contrary, NOTCH2, NOTCH3, DLL3, DLL4, JAG1, JAG2, HEY1 and HEY2 mRNA levels were downregulated in PE samples vs. controls (p<0.01).
BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells.
Ahn et al., Seoul, South Korea. In Mol Cancer, 2014
BMP4 up-regulated JAG2, an upstream factor of miR-200; therefore, JAG2, miR-200, and BMP4 form a regulatory loop.
Genome-wide copy-number variation study of psychosis in Alzheimer's disease.
Feingold et al., Pittsburgh, United States. In Transl Psychiatry, 2014
JAG2 (P=5.01E-07) and ZFPM1 (P=2.13E-07)
Possible roles of DLK1 in the Notch pathway during development and disease.
Review
Gaemers et al., Amsterdam, Netherlands. In Biochim Biophys Acta, 2012
In mammals, four Notch receptors (NOTCH1-4) and five activating canonical ligands (JAGGED1, JAGGED2, DLL1, DLL3 and DLL4) have been described.
Critical role of the NOTCH ligand JAG2 in self-renewal of myeloma cells.
GeneRIF
Pellat-Deceunynck et al., Nantes, France. In Blood Cells Mol Dis, 2012
JAG2 is often expressed by CD138(+) primary cells. Our results indicate that spontaneous clonogenic growth of myeloma cells requires the expression of JAG2.
Downregulation of Notch-1/Jagged-2 in human colon tissues from Hirschsprung disease patients.
GeneRIF
Wang et al., Shenyang, China. In Int J Colorectal Dis, 2012
This study is the first illustration of Notch-1 and Jagged-2 expression in human tissues from non-cancerous disease.
P4 down-regulates Jagged2 and Notch1 expression during primordial folliculogenesis.
GeneRIF
Zhang et al., Beijing, China. In Front Biosci (elite Ed), 2011
results demonstrate that maternal P4 levels during midpregnancy can inhibit the expression of Jagged2 and Notch1, which are involved in primordial folliculogenesis, in the mouse fetal ovary
Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells.
GeneRIF
Watabe et al., Springfield, United States. In Oncogene, 2011
hypoxia-induced Jagged2 activation in both tumor invasive front and normal bone stroma has a critical role in tumor progression and metastasis
Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells.
GeneRIF
Krampera et al., Verona, Italy. In Blood, 2011
The stromal cell-mediated antiapoptotic effect on B- ALL cells is mediated by Notch-3 and -4 or Jagged-1/-2 and DLL-1 in a synergistic manner.
Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.
Review
Katoh et al., Japan. In Curr Mol Med, 2009
GLI activators bind to GACCACCCA motif to regulate transcription of GLI1, PTCH1, PTCH2, HHIP1, MYCN, CCND1, CCND2, BCL2, CFLAR, FOXF1, FOXL1, PRDM1 (BLIMP1), JAG2, GREM1, and Follistatin.
Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review).
Review
Katoh et al., Japan. In Int J Mol Med, 2008
GLI activators then upregulate CCND1, CCND2 for cell cycle acceleration, FOXA2, FOXC2, FOXE1, FOXF1, FOXL1, FOXP3, POU3F1, RUNX2, SOX13, TBX2 for cell fate determination, JAG2, INHBC, and INHBE for stem cell signaling regulation.
Dysregulation of stem cell signaling network due to germline mutation, SNP, Helicobacter pylori infection, epigenetic change and genetic alteration in gastric cancer.
Review
Katoh, Tokyo, Japan. In Cancer Biol Ther, 2007
Hedgehog signals induce upregulation of GLI1, PTCH1, CCND2, FOXL1, JAG2 and SFRP1 genes.
Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis.
Review
Katoh, Tokyo, Japan. In Stem Cell Rev, 2007
Hedgehog signals induce upregulation of SFRP1, JAG2 and FOXL1, and then FOXL1 induces BMP4 upregulation.
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