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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Septin 9

SEPT9, Septin 9
This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2009] (from NCBI)
Top mentioned proteins: CAN, SEP2, HAD, MLL, Actin
Papers on SEPT9
Early detection of colorectal cancer: from conventional methods to novel biomarkers.
Review
New
Salehi et al., Eşfahān, Iran. In J Cancer Res Clin Oncol, Feb 2016
In particular, DNA methylation markers (e.g., SEPT9, SFRP2, and ALX4), circulating microRNAs (e.g., microRNA21), SNPs in microRNAs binding site (e.g., rs4596 located within a target region of the predicted miR-518a-5p and miR-527), protein markers (e.g., carcinoembryonic antigen, N-methyltransferase), or microsatellites instability in tumors with deficient mismatch repair of some genes are among the most interesting and promising biomarkers.
Development of Castration Resistant Prostate Cancer Can Be Predicted by a DNA Hypermethylation Profile.
New
Ropero et al., Getafe, Spain. In J Urol, Dec 2015
Hypermethylation of IRAK3 (HR 13.72), ZNF215 (HR 4.81) and SEPT9 (HR 7.64) were independent markers of prognosis.
Next generation sequencing in synovial sarcoma reveals novel gene mutations.
New
Versleijen-Jonkers et al., Nijmegen, Netherlands. In Oncotarget, Nov 2015
Additional mutations were detected in RNF213, SEPT9, KDR, CSMD3, MLH1 and ERBB4.
Septin 9 Exhibits Polymorphic Binding to F-Actin and Inhibits Myosin and Cofilin Activity.
New
Galkin et al., Norfolk, United States. In J Mol Biol, Nov 2015
Septin 9 (SEPT9) interacts directly with actin filaments and functions as an actin stress fiber cross-linking protein that promotes the maturation of nascent focal adhesions and cell migration.
Novel Host Proteins and Signaling Pathways in Enteropathogenic E. coli Pathogenesis Identified by Global Phosphoproteome Analysis.
New
Finlay et al., Vancouver, Canada. In Mol Cell Proteomics, Jul 2015
We determined the biological relevance of the phosphorylation of a novel protein in EPEC pathogenesis, septin-9 (SEPT9).
Comparison of genetic and epigenetic alterations of primary tumors and matched plasma samples in patients with colorectal cancer.
Guidi et al., Verona, Italy. In Plos One, 2014
KRAS and SEPT9 status was assessed by allele refractory mutation system quantitative PCR and quantitative methylation-specific PCR, respectively.
Simultaneous Analysis of SEPT9 Promoter Methylation Status, Micronuclei Frequency, and Folate-Related Gene Polymorphisms: The Potential for a Novel Blood-Based Colorectal Cancer Biomarker.
Angelini et al., Bologna, Italy. In Int J Mol Sci, 2014
The present study investigated the promoter methylation status of the SEPT9 gene in peripheral blood samples of subjects' positive fecal occult blood test (FOBT).
Epigenomic profiling of prostate cancer identifies differentially methylated genes in TMPRSS2:ERG fusion-positive versus fusion-negative tumors.
Stanford et al., Seattle, United States. In Clin Epigenetics, 2014
A number of top-ranked differentially methylated CpGs in genes (FDR Q-values ≤1.53E-29) were identified: C3orf14, CACNA1D, GREM1, KLK10, NT5C, PDE4D, RAB40C, SEPT9, and TRIB2, several of which had a corresponding alteration in mRNA expression.
Aberrant methylation patterns in cancer: a clinical view.
Review
Hudler et al., Ljubljana, Slovenia. In Biochem Med (zagreb), 2014
Even more, promoter methylation patterns of some genes, such as MGMT, SHOX2, and SEPT9, have already been translated into commercial clinical assays aiding in patient assessment as adjunct diagnostic tools.
Methylation of cell-free circulating DNA in the diagnosis of cancer.
Review
Samimi et al., Sydney, Australia. In Front Mol Biosci, 2014
A commercial blood test for colorectal cancer based on the methylation of the SEPT9 promoter region in circDNA is under review for approval by the Federal Drug Administration (FDA) for clinical use.
SEPT9: A Specific Circulating Biomarker for Colorectal Cancer.
Review
Li et al., Beijing, China. In Adv Clin Chem, 2014
In this chapter, we will first provide the background on the role of septin9 protein and the theoretical basis of the SEPT9 gene methylation assay.
Novel loci for non-syndromic coarctation of the aorta in sporadic and familial cases.
Toka et al., Erlangen, Germany. In Plos One, 2014
We identified one CNV locus within a locus with high multipoint LOD score from a linkage analysis of the familial cases (SEPT9); another locus overlapped with a region implicated in Kabuki syndrome.
Cost-effectiveness of colorectal cancer screening in Germany: current endoscopic and fecal testing strategies versus plasma methylated Septin 9 DNA.
Brueggenjuergen et al., Stanford, United States. In Endosc Int Open, 2014
Blood-based biomarkers, such as methylated Septin 9 DNA ( (m) SEPT9), may improve screening rates.
Detection of colorectal cancer by DNA methylation biomarker SEPT9: past, present and future.
Review
He et al., Beijing, China. In Biomark Med, 2013
Peripheral blood SEPT9 gene methylation assay has become a potential option with promising future for early detection and screening of colorectal cancer.
Expression of the SEPT9_i4 isoform confers resistance to microtubule-interacting drugs.
GeneRIF
Russell et al., Belfast, United Kingdom. In Cell Oncol (dordr), 2012
SEPT9_v4 expression may be clinically relevant and contribute to some forms of drug resistance.
SEPT9 occupies the terminal positions in septin octamers and mediates polymerization-dependent functions in abscission.
GeneRIF
Trimble et al., Toronto, Canada. In J Cell Biol, 2011
SEPT9 holds a terminal position in the septin octamers, mediating abscission-specific polymerization during cytokinesis.
Characterization of human septin interactions.
GeneRIF
Zieger et al., Freiburg, Germany. In Biol Chem, 2011
Data illustrated roles of SEPT9 that might contribute to hetero-trimeric septin complex formation. SEPT9 can substitute for septins of the SEPT2 group and partially for SEPT7.
Septin9 is involved in septin filament formation and cellular stability.
GeneRIF
Füchtbauer et al., Århus, Denmark. In Biol Chem, 2011
Data reveal the importance of Sept9 for septin filament formation and general cell stability.
Septin 9 isoform expression, localization and epigenetic changes during human and mouse breast cancer progression.
GeneRIF
Montagna et al., United States. In Breast Cancer Res, 2010
SEPT9 gene amplification and overexpression during mouse breast tumorigenesis
Mutations in SEPT9 cause hereditary neuralgic amyotrophy.
Impact
GeneRIF
Chance et al., Münster, Germany. In Nat Genet, 2005
Three mutations in the gene septin 9 (SEPT9) in six families with hereditary neuralgic amyotrophy linked to chromosome 17q25 were reported.
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