Centrosomes in the DNA damage response-the hub outside the centre.
Galway, Ireland. In Chromosome Res, Dec 2015
We discuss several potential mechanisms for how centrosome numbers become dysregulated after DNA damage and explore the links between the DDR and the PLK1- and separase-dependent mechanisms that drive centriole separation and reduplication.
Chromosome Dynamics during Mitosis.
Wako, Japan. In Cold Spring Harb Perspect Biol, Jun 2015
In anaphase, this connection is released by the action of separase that proteolytically cleaves the remaining population of cohesin.
Sharpening the anaphase switch.
Coventry, United Kingdom. In Biochem Soc Trans, Feb 2015
This leads to the activation of separase, a specialized protease that cleaves the kleisin-subunit of the cohesin complex, to relieve cohesion between sister chromatids.
Solving the centriole disengagement puzzle.
In Nat Cell Biol, 2015
Plk1-mediated degradation of Cep68 and separase-mediated cleavage of pericentrin release both pools of Cep215, thereby promoting centriole disengagement.
Cyclin B2 and p53 control proper timing of centrosome separation.
Rochester, United States. In Nat Cell Biol, 2014
Cyclins B1 and B2 both induce aneuploidy when overexpressed but through distinct mechanisms, with cyclin B1 inhibiting separase activation, leading to anaphase bridges, and cyclin B2 triggering aurora-A-mediated Plk1 hyperactivation, resulting in accelerated centrosome separation and lagging chromosomes.