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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Extra spindle pole bodies homolog 1

separase, CRIP, Esp1, cut1
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010] (from NCBI)
Top mentioned proteins: CAN, Scc1, PCNA, APC, CDC2
Papers using separase antibodies
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2
Gruneberg Ulrike et al., In The Journal of Cell Biology, 2009
... (BD), mouse anti-Sgo1 (Abcam), rabbit anti-Sgo2 (Bethyl Laboratories, Inc.), mouse anti-securin (Bethyl Laboratories, Inc.), mouse anti-separase (Abcam), rabbit anti-separase (Bethyl Laboratories, ...
Papers on separase
Co-expression of galectin-3 and CRIP-1 in endometrial cancer: prognostic value and patient survival.
Chatzaki et al., Alexandroúpolis, Greece. In Med Oncol, Jan 2016
Galectin-3 (GAL-3) and CRIP-1 are multifunctional proteins which seem to be involved in many neoplasias.
Centrosomes in the DNA damage response-the hub outside the centre.
Morrison et al., Galway, Ireland. In Chromosome Res, Dec 2015
We discuss several potential mechanisms for how centrosome numbers become dysregulated after DNA damage and explore the links between the DDR and the PLK1- and separase-dependent mechanisms that drive centriole separation and reduplication.
Elucidation of novel budding yeast separase mutants.
Ushimaru et al., Shizuoka, Japan. In Biosci Biotechnol Biochem, Dec 2015
Here, we isolated and characterized 10 temperature-sensitive (ts) mutants of separase ESP1 in the budding yeast Saccharomyces cerevisiae.
Structural Insights into Separase Architecture and Substrate Recognition through Computational Modelling of Caspase-Like and Death Domains.
Bayliss et al., Leicester, United Kingdom. In Plos Comput Biol, Oct 2015
A comparative model of the single C-terminal caspase-like domain in separase from C. elegans suggests similar binding modes of substrate peptides between these protein subfamilies, and enables differences in substrate specificity of separase proteins to be rationalised.
Chromosome Dynamics during Mitosis.
Hirano, Wako, Japan. In Cold Spring Harb Perspect Biol, Jun 2015
In anaphase, this connection is released by the action of separase that proteolytically cleaves the remaining population of cohesin.
Sharpening the anaphase switch.
Millar et al., Coventry, United Kingdom. In Biochem Soc Trans, Feb 2015
This leads to the activation of separase, a specialized protease that cleaves the kleisin-subunit of the cohesin complex, to relieve cohesion between sister chromatids.
From sexual attraction to maternal aggression: when pheromones change their behavioural significance.
Martínez-Garcia et al., Burjassot, Spain. In Horm Behav, Feb 2015
Non-urinary male chemosignals, such as the lacrimal protein ESP1, promote lordosis in female mice, but its attractive properties are still to be tested.
Solving the centriole disengagement puzzle.
Fry, In Nat Cell Biol, 2015
Plk1-mediated degradation of Cep68 and separase-mediated cleavage of pericentrin release both pools of Cep215, thereby promoting centriole disengagement.
PLK1 regulation of PCNT cleavage ensures fidelity of centriole separation during mitotic exit.
Rhee et al., Seoul, South Korea. In Nat Commun, 2014
It was previously known that separase specifically cleaves pericentrin (PCNT) during mitotic exit.
Characterization of a DNA exit gate in the human cohesin ring.
Peters et al., Vienna, Austria. In Science, 2014
These open forms may resemble intermediate states of cohesin normally generated by the release factor Wapl and the protease separase, respectively.
Cyclin B2 and p53 control proper timing of centrosome separation.
van Deursen et al., Rochester, United States. In Nat Cell Biol, 2014
Cyclins B1 and B2 both induce aneuploidy when overexpressed but through distinct mechanisms, with cyclin B1 inhibiting separase activation, leading to anaphase bridges, and cyclin B2 triggering aurora-A-mediated Plk1 hyperactivation, resulting in accelerated centrosome separation and lagging chromosomes.
Wapl is an essential regulator of chromatin structure and chromosome segregation.
Peters et al., Vienna, Austria. In Nature, 2013
In mitosis, Wapl-mediated release of cohesin from DNA is essential for proper chromosome segregation and protects cohesin from cleavage by the protease separase, thus enabling mitotic exit in the presence of functional cohesin complexes.
Post-replicative repair involves separase-dependent removal of the kleisin subunit of cohesin.
Aragón et al., London, United Kingdom. In Nature, 2013
Here we show that DNA breaks promote dissociation of cohesin loaded during the previous S phase in budding yeast, and that damage-induced dissociation of cohesin requires separase, the protease that dissolves cohesion in anaphase.
Molecular participants in regulation of the meiotic cell cycle in mammalian oocytes.
Dekel et al., Israel. In Reprod Fertil Dev, 2012
The latest findings regarding the contribution of ubiquitin chain topology, separase, securin, cyclin B1, CDK1, Polo-like kinase 1 and mitogen-activated protein kinase kinase 1/2 to the regulation of meiosis are discussed.
Separase sensor reveals dual roles for separase coordinating cohesin cleavage and cdk1 inhibition.
Hirota et al., Tokyo, Japan. In Dev Cell, 2012
By consecutively acting as a protease and a cdk1 inhibitor, separase coordinates two key processes to achieve simultaneous and abrupt separation of sister chromatids.
Separase biosensor reveals that cohesin cleavage timing depends on phosphatase PP2A(Cdc55) regulation.
Morgan et al., San Francisco, United States. In Dev Cell, 2012
Separase acts directly on Scc1 and also indirectly, through inhibition of PP2A(Cdc55), to stimulate cohesin cleavage, providing a feedforward loop that may contribute to a robust and timely anaphase.
Shugoshins: from protectors of cohesion to versatile adaptors at the centromere.
Pendás et al., Salamanca, Spain. In Trends Genet, 2012
Shugoshin proteins protect cohesin from cleavage by separase during meiosis I in eukaryotes and from phosphorylation-mediated removal during mitosis in vertebrates.
Kendrin is a novel substrate for separase involved in the licensing of centriole duplication.
Takahashi et al., Ichihara, Japan. In Curr Biol, 2012
Kendrin is a novel and crucial substrate for separase (ESPL1) at the centrosome, protecting the engaged centrioles from premature disengagement and thereby blocking reduplication until the cell passes through mitosis.
The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma.
Lung et al., Hong Kong, Hong Kong. In Cancer Lett, 2012
CRIP2 expression is down-regulated in ESCC tissues and cell lines.
CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients.
Nathrath et al., Basel, Switzerland. In Oncotarget, 2011
CRIP1 expression is associated with long-term survival and no metastases in osteosarcoma patients.
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