Gated entry into the ciliary compartment.
Ann Arbor, United States. In Cell Mol Life Sci, Nov 2015
For membrane proteins, the septin protein SEPT2 is part of the barrier to entry whereas the gating function is carried out and/or regulated by proteins associated with ciliary diseases (ciliopathies) such as nephronophthisis, Meckel-Gruber syndrome and Joubert syndrome.
The Proteomic Analysis of Human Placenta with Pre-eclampsia and Normal Pregnancy.
Suwŏn, South Korea. In J Korean Med Sci, Jun 2015
In preeclamptic placenta 9 differentially expressed proteins were down-regulated with Hsp 70, serum albumin crystal structure chain A, lamin B2, cytokeratin 18, actin cytoplasmic, alpha fibrinogen precursor, septin 2, dihydrolipoamide branched chain transacylase E2 and firbrinogen beta chain.
Self assembly of human septin 2 into amyloid filaments.
São Carlos, Brazil. In Biochimie, 2012
The results shown in study support the hypothesis that single Septin 2, when present in excess or with unbalanced stoichiometries, may be unstable and assemble into amyloid-like structures.