SENP5 mediates breast cancer invasion via a TGFβRI SUMOylation cascade.
Ramat Gan, Israel. In Oncotarget, 2014
By iterating over the compendia of genes, we screened for their significance as prognosis biomarkers and identified SUMO-specific protease 5 (SENP5) to significantly stratify patients into two survival groups across five unrelated tested datasets.
The SUMO-specific protease SENP5 is required for cell division.
Boston, United States. In Mol Cell Biol, 2006
Knockdown of SENP5 resulted in increased levels of SUMO-1 and SUMO-2/3, inhibition of cell proliferation, defects in nuclear morphology, and appearance of binucleate cells, revealing an essential role for SENP5 in mitosis and/or cytokinesis.