SUMO routes ribosome maturation.
Martinsried, Germany. In Nucleus, 2011
In particular, removal of SUMO from trans-acting factors by the SUMO-specific isopeptidase SENP3 is instrumental in the 60S maturation pathway in mammals.
Coronin 2A mediates actin-dependent de-repression of inflammatory response genes.
San Diego, United States. In Nature, 2011
Intriguingly, the LXR transrepression pathway can itself be inactivated by inflammatory signals that induce calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)-dependent phosphorylation of LXRs, leading to their deSUMOylation by the SUMO protease SENP3 and release from CORO2A.
SENP1 participates in the dynamic regulation of Elk-1 SUMOylation.
Manchester, United Kingdom. In Biochem J, 2010
Results demonstrate that SENP1 is the most efficient SUMO protease acting on Elk-1, and that SENP3 has little effect on Elk-1. SENP2 has an intermediate effect, but its ability to activate Elk-1 is independent from its SUMO-deconjugating activity.