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proteins. Page last changed on 08 Dec 2016.
SUMO1/sentrin/SMT3 specific peptidase 2
SENP2, SuPr-1, sentrin-specific protease
SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004] (from
Abe et al., Houston, United States. In Antioxid Redox Signal, Jan 2016
In addition, PKCζ activation plays a role in regulating SUMOylation-related enzymes of PIAS4, p90RSK activation plays a role in regulating SUMOylation-related enzymes of SENP2, and DNA methyltransferase, SUMOylation may play a role in d-flow signaling.
Turk et al., Ljubljana, Slovenia. In J Biol Chem, Dec 2015
Althoughthese substrates were cleaved by cathepsins, making them unsuitable for analysis of complex cellular systems, they were recognized exclusively by TcAtg4.2, but not by HsAtg4B nor by the structurally related human proteases SENP1, SENP2, and UCH-L3.
We have previously shown that d-flow increases SUMOylation of p53 and ERK5 through downregulation of sentrin/SUMO-specific protease 2 (SENP2) function; however, it is not known how SENP2 itself is regulated by d-flow.
Tschan et al., Bern, Switzerland. In Leuk Res Rep, 2014
In an mRNA profiling screen performed to unveil novel mechanisms of leukemogenesis, we found that the sentrin-specific protease 5 (SENP5) was significantly repressed in clinical acute myeloid leukemia when compared to healthy neutrophil samples.
Shu et al., Wuhan, China. In J Mol Cell Biol, 2011
Data suggest that SENP2 regulates antiviral innate immunity by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation, and provide an example of cross-talk between the ubiquitin and SUMO pathways in innate immunity.