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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

SUMO1/sentrin specific peptidase 1

SENP1
The covalent modification of proteins by the small ubiquitin (UBB; MIM 191339)-like protein SUMO (see SUMO1, MIM 601912) is implicated in the regulation of nucleocytoplasmic transport, genomic stability, gene transcription, and other processes. Sumoylation is catalyzed on target lysine residues by a multienzyme process and is reversed by desumoylating enzymes such as SENP1 (Yamaguchi et al., 2005 [PubMed 15923632]).[supplied by OMIM, Jul 2008] (from NCBI)
Top mentioned proteins: Smt3, Ubiquitin, DAPI, CAN, SUMO-2
Papers using SENP1 antibodies
Activity-dependent endocytic sorting of kainate receptors to recycling or degradation pathways.
Supplier
Feng Zhong-Ping, In PLoS ONE, 2003
... (1/240; Invitrogen, Carlsbad, CA, USA), mouse anti-Ubc9 (1/200, BD Bioscience, Rungis, France), goat anti-AoS1, rabbit anti-SENP1 and goat anti-SENP6 (1/200, Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Papers on SENP1
Regulation of mGluR7 trafficking by SUMOylation in neurons.
New
Suh et al., Suwŏn, South Korea. In Neuropharmacology, Mar 2016
In the present study, we find that mGluR7 at Lys889 is a target of SUMO conjugation, which is impeded by SUMO-specific isopeptidase SENP1 in HEK 293T cells.
Evaluation of the activity and substrate specificity of the human SENP family of SUMO proteases.
New
Pinto et al., Porto, Portugal. In Biochim Biophys Acta, Jan 2016
The reversibility of SUMOylation is ensured by SUMO proteases many of which belong to the sentrin/SUMO-specific protease (SENP) family.
SENP1 regulates hepatocyte growth factor-induced migration and epithelial-mesenchymal transition of hepatocellular carcinoma.
New
Wang et al., Shenyang, China. In Tumour Biol, Jan 2016
In this study, we demonstrated that HCC cells express a high level of SUMO/sentrin-specific protease 1 (Senp1) which is induced by HGF/c-Met signals.
New genetic and physiological factors for excessive erythrocytosis and Chronic Mountain Sickness.
Review
New
Villafuerte, Lima, Peru. In J Appl Physiol, Jan 2016
The recent finding of the association of the CMS phenotype with a single-nucleotide polymorphism (SNP) in the Sentrin-specific Protease 1 (SENP1) gene, and its differential expression pattern in Andean highlanders with and without CMS, has triggered large interest in high-altitude studies because of the potential role of its gene product in the control of erythropoiesis.
SENP1 inhibits the IH-induced apoptosis and nitric oxide production in BV2 microglial cells.
New
Ren et al., Shanghai, China. In Biochem Biophys Res Commun, Dec 2015
We found that SENP1 was significantly down-regulated in cells exposure to IH.
SUMOylation Confers Posttranslational Stability on NPM-ALK Oncogenic Protein.
New
Amin et al., Shanghai, China. In Neoplasia, Sep 2015
Importantly, antagonizing SUMOylation by the SENP1 protease decreased the accumulation of NPM-ALK and suppressed lymphoma cell viability, proliferation, and anchorage-independent colony formation.
[Effects of SUMO specific protease 1 on hPXR-mediated P-gp gene expression].
New
Chen et al., In Yao Xue Xue Bao, Sep 2015
The study aimed to investigate the effects of small ubiquitin-related modifier (SUMO) specific protease 1 (SENP1) on human PXR-mediated MDR1 transcriptional activity and mRNA expression.
Higher androgen bioactivity is associated with excessive erythrocytosis and chronic mountain sickness in Andean Highlanders: a review.
Review
New
Chaupis et al., Lima, Peru. In Andrologia, Sep 2015
Men with CMS at Peruvian Central Andes have two genes SENP1, and ANP32D with higher transcriptional response to hypoxia relative to those without.
SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression.
Min et al., Guangzhou, China. In Nat Commun, 2014
Here we show that mice with a adipocyte-specific deletion of the SUMO-specific protease SENP1 gene develop symptoms of type-1 diabetes mellitus (T1DM), including hyperglycaemia and glucose intolerance with mild insulin resistance.
SENP1 desensitizes hypoxic ovarian cancer cells to cisplatin by up-regulating HIF-1α.
Huang et al., Wuhan, China. In Sci Rep, 2014
Although it is reported that HIF-1α can be regulated by Sentrin/SUMO-specific protease 1 (SENP1), the effects of SENP1 on HIF-1α is still controversial.
Lens epithelium-derived growth factor deSumoylation by Sumo-specific protease-1 regulates its transcriptional activation of small heat shock protein and the cellular response.
GeneRIF
Singh et al., Omaha, United States. In Febs J, 2012
mutation of K364 to arginine (R) or deSumoylation by small ubiquitin-like modifier (Sumo)-specific protease-1, a nuclear deSumoylase, enhanced the transactivation capacity of LEDGF and its cellular abundance
SENP1 deficiency promotes ER stress-induced apoptosis by increasing XBP1 SUMOylation.
GeneRIF
Cheng et al., Shanghai, China. In Cell Cycle, 2012
SENP1 is essential for cell survival during endoplasmic reticulum stress.
SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation.
GeneRIF
Yeh et al., Houston, United States. In Mol Cell, 2012
SENP1 is essential for the development of early T and B cells.
SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitors.
GeneRIF
Chen et al., Shanghai, China. In Cancer Lett, 2011
SENP1 might play a role in cell cycle regulation of colon cancer cells
The role of Co²+ in the crystallization of human SENP1 and comments on the limitations of automated refinement protocols.
GeneRIF
Hunter et al., Dundee, United Kingdom. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011
crystal structure of human SENP1 was redetermined at 2.4 A degrees resolution with Rwork and Rfree values of 23.1% and 31.3%, respectively
SUMO proteases: redox regulation and biological consequences.
Review
Au et al., Hong Kong, Hong Kong. In Antioxid Redox Signal, 2009
Findings on the oxidation-induced intermolecular disulfide of E1-E2 ligases and SENP1/2 have improved our understanding of the mechanism by which modification is switched up or down.
FRET-based in vitro assays for the analysis of SUMO protease activities.
Review
Hay et al., Dundee, United Kingdom. In Methods Mol Biol, 2008
In humans cells three SUMO paralogues (SUMO-1, SUMO-2 and SUMO-3) and six SUMO specific proteases (SENP1-SENP3 and SENP5-SENP7) are expressed.
Preparation of SUMO proteases and kinetic analysis using endogenous substrates.
Review
Lima et al., Barcelona, Spain. In Methods Mol Biol, 2008
The SUMO protease family includes two members in yeast (Ulp1 and Ulp2) and as many as six members in human (SENP1-3, SENP5-7).
SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia.
Impact
GeneRIF
Yeh et al., Houston, United States. In Cell, 2007
These results show that SENP1 plays a key role in the regulation of the hypoxic response through regulation of HIF1alpha stability and that SUMOylation can serve as a direct signal for ubiquitin-dependent degradation.
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress.
Impact
Bai et al., Tampa, United States. In Nat Cell Biol, 2007
Conversely, mutation of SIRT1 at Lys 734 or desumoylation by SENP1, a nuclear desumoylase, reduced its deacetylase activity.
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