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SEN34 Sen34p

Sen34, Sen34p, HsSen34
This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: sen2, HsSen15, Sen54, STEP, Exportin-t
Papers on Sen34
[Recommendations for the perinatal management and follow up of late preterm newborns].
Demestre Guasch et al., Spain. In An Pediatr (barc), 2014
The SEN34-36 group of the Spanish Society of Neonatology suggests these recommendations for the management of late preterm babies.
Three-dimensional structure determined for a subunit of human tRNA splicing endonuclease (Sen15) reveals a novel dimeric fold.
Markley et al., Madison, United States. In J Mol Biol, 2007
Splicing of eukaryal intron-containing tRNAs requires the action of the heterotetrameric splicing endonuclease, which is composed of two catalytic subunits, Sen34 and Sen2, and two structural subunits, Sen15 and Sen54.
Cleavage of pre-tRNAs by the splicing endonuclease requires a composite active site.
Peltz et al., South Plainfield, United States. In Nature, 2006
The first step of splicing, intron recognition and cleavage, is performed by the tRNA-splicing endonuclease, a tetrameric enzyme composed of the protein subunits Sen54, Sen2, Sen34 and Sen15.
Sen34p depletion blocks tRNA splicing in vivo and delays rRNA processing.
Biffo et al., Milano, Italy. In Biochem Biophys Res Commun, 2005
Sen34p is absolutely required for tRNA splicing and may affect also rRNA maturation.
Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation.
Trotta et al., South Plainfield, United States. In Cell, 2004
This enzyme consists of HsSen2, HsSen34, HsSen15, and HsSen54, homologs of the yeast tRNA endonuclease subunits.
Possibility of cytoplasmic pre-tRNA splicing: the yeast tRNA splicing endonuclease mainly localizes on the mitochondria.
Endo et al., Nagoya, Japan. In Mol Biol Cell, 2003
In yeast, the tRNA splicing endonuclease that cleaves the exon-intron junctions of pre-tRNAs consists of Sen54p, Sen2p, Sen34p, and Sen15p and was thought to be an integral membrane protein of the inner nuclear envelope.
Identification of two catalytic subunits of tRNA splicing endonuclease from Arabidopsis thaliana.
Beier et al., Matsue, Japan. In Gene, 2000
Sen34 and Sen44, contain the active sites for cleavage at the 3'- and 5'-splice sites, respectively.
The yeast tRNA splicing endonuclease: a tetrameric enzyme with two active site subunits homologous to the archaeal tRNA endonucleases.
Abelson et al., Pasadena, United States. In Cell, 1997
Two subunits, Sen2p and Sen34p, contain a homologous domain of approximately 130 amino acids.
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