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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Amine oxidase, copper containing 3

semicarbazide-sensitive amine oxidase, SSAO, VAP-1, vascular adhesion protein-1
Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The product is a major protein on the adipocyte plasma membrane. It has adhesive properties and also has functional monoamine oxidase activity. A pseudogene for this gene has been discribed and is located approximately 9-kb downstream. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Monoamine Oxidase, CAN, Insulin, HAD, AGE
Papers on semicarbazide-sensitive amine oxidase
Vascular adhesion protein-1: Role in human pathology and application as a biomarker.
Speeckaert et al., Gent, Belgium. In Crit Rev Clin Lab Sci, Dec 2015
Vascular adhesion protein-1 (VAP-1) is a member of the copper-containing amine oxidase/semicarbazide-sensitive amine oxidase (AOC/SSAO) enzyme family.
Interstitial renal fibrosis due to multiple cisplatin treatments is ameliorated by semicarbazide-sensitive amine oxidase inhibition.
Noiri et al., Tokyo, Japan. In Kidney Int, Dec 2015
Oral administration of a recently reported selective semicarbazide-sensitive amine oxidase inhibitor, PXS-4728A, for 1 week attenuated kidney injury and interstitial fibrosis compared with vehicle.
Disruption of phactr-1 pathway triggers pro-inflammatory and pro-atherogenic factors: New insights in atherosclerosis development.
Lepelletier et al., Villejuif, France. In Biochimie, Nov 2015
Besides, Phactr-1 down-expression also induces emerging atherosclerosis biomarkers such as semicarbazide-sensitive amine oxidase (SSAO) and TGF-beta-inducible gene h3 (βIG-H3).
Circulating renalase, catecholamines, and vascular adhesion protein 1 in hypertensive patients.
Malyszko et al., Białystok, Poland. In J Am Soc Hypertens, Nov 2015
The aim of the study was to estimate and correlate circulating levels of renalase, vascular adhesion protein-1 (VAP-1), catecholamines in patients with primary hypertension.
Protective effect of the multitarget compound DPH-4 on human SSAO/VAP-1-expressing hCMEC/D3 cells under oxygen-glucose deprivation conditions: an in vitro experimental model of cerebral ischaemia.
Solé et al., Barcelona, Spain. In Br J Pharmacol, Nov 2015
Plasma levels of semicarbazide-sensitive amine oxidase/vascular adhesion protein 1 (SSAO/VAP-1, also known as Primary Amine Oxidase -PrAO) are increased in both stroke and AD patients and contribute to the vascular damage.
Inhibition and oxygen activation in copper amine oxidases.
Dooley et al., Bozeman, United States. In Acc Chem Res, Jun 2015
This is vital given the existence of human diamine oxidase and vascular adhesion protein-1, which have distinct amine substrate preferences and are associated with different metabolic processes.
68Ga-DOTA-Siglec-9--a new imaging tool to detect synovitis.
Roivainen et al., Turku, Finland. In Arthritis Res Ther, 2014
INTRODUCTION: Vascular adhesion protein-1 (VAP-1) is an adhesion molecule, which upon inflammation is rapidly translocated from intracellular sources to the endothelial cell surface.
Semicarbazide-sensitive amine oxidase and kidney disease.
Wong et al., Australia. In Am J Physiol Renal Physiol, 2014
In this review, we discuss mechanistic aspects in the physiological and pathological role of semicarbazide-sensitive amine oxidase, a protein enzyme involved in cellular trafficking and inflammation, with respect to the kidney.
Adhesion molecules in CNS disorders: biomarker and therapeutic targets.
Tang et al., Loma Linda, United States. In Cns Neurol Disord Drug Targets, 2013
Lately, vascular adhesion protein-1, a novel adhesion molecule and endothelial cell surface enzyme, has been implicated as a brake in the rolling step of the adhesion cascade, and also a regulator of leukocyte transmigration step.
Vascular adhesion protein-1 and syndecan-1 in septic shock.
Pettilä et al., Helsinki, Finland. In Acta Anaesthesiol Scand, 2012
We found increased VAP-1 activity and anchor protein syndecan-1 content in critically ill patients with septic shock
VAP-1/SSAO plasma activity and brain expression in human hemorrhagic stroke.
Montaner et al., Barcelona, Spain. In Cerebrovasc Dis, 2011
Plasma VAP-1/SSAO activity is increased in intracranial hemorrhage and predicts neurological outcome, suggesting a possible contribution of the soluble protein in secondary brain damage.
Implication for functions of the ectopic adipocyte copper amine oxidase (AOC3) from purified enzyme and cell-based kinetic studies.
Klinman et al., Berkeley, United States. In Plos One, 2011
The demonstrated AOC3 turnover of primary amines that are non-native to human tissue suggests possible roles for the adipocyte enzyme in subcutaneous bacterial infiltration and obesity.
Immunolocalization of vascular adhesion protein-1 in human conjunctival tumors.
Ishida et al., Sapporo, Japan. In Ophthalmic Res, 2011
The immunolocalization of VAP-1 varied in the histopathology of the conjunctiva, involving the pathology of inflammatory conjunctival disorders.
Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer.
Jalkanen et al., Turku, Finland. In Blood, 2011
The Siglec-9 peptide binding to the enzymatic groove of VAP-1 can be used for imaging conditions, such as inflammation and cancer.
Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1: a patent survey.
Mátyus et al., Budapest, Hungary. In Expert Opin Ther Pat, 2011
INTRODUCTION: Vascular adhesion protein-1 (VAP-1)/semicarbazide-sensitive amine oxidase (SSAO) is an adhesion protein involved in leukocyte trafficking and inflammatory processes, with a special amine oxidase activity.
Homing-associated molecules CD73 and VAP-1 as targets to prevent harmful inflammations and cancer spread.
Jalkanen et al., Turku, Finland. In Febs Lett, 2011
Homing-associated molecules are of fundamental importance for proper functioning of our immune system as they direct the cells to sites of inflammation to create an immune response.
Rules of recruitment for Th1 and Th2 lymphocytes in inflamed liver: a role for alpha-4 integrin and vascular adhesion protein-1.
Kubes et al., Calgary, Canada. In Immunity, 2005
T helper type 2 cells use Vap-1 to roll and adhere in the inflamed liver microcirculation
Absence of the endothelial oxidase AOC3 leads to abnormal leukocyte traffic in vivo.
Salmi et al., Turku, Finland. In Immunity, 2005
We produced mice deficient in an endothelial cell-surface oxidase (amine oxidase, copper containing-3 [AOC3], also known as vascular adhesion protein-1 [VAP-1]) and found that this enzyme is needed for leukocyte extravasation in vivo.
A cell surface amine oxidase directly controls lymphocyte migration.
Jalkanen et al., Turku, Finland. In Immunity, 2001
Vascular adhesion molecule-1 (VAP-1) is a surface-expressed endothelial glycoprotein, which belongs to a distinct subgroup of monoamine oxidases.
Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product.
Bustelo et al., Bethesda, United States. In Nature, 1997
6), Vap-1 (ref.
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