Retrograde signaling for climbing fiber synapse elimination.
Tokyo, Japan. In Cerebellum, Feb 2015
Here, we show that semaphorin3A (Sema3A) and semaphorin7A (Sema7A) mediate retrograde signals for elimination of redundant climbing fiber (CF) to Purkinje cell (PC) synapses in the developing cerebellum, a representative model of synapse elimination in the central nervous system.
Neuropilin regulation of angiogenesis.
London, United Kingdom. In Biochem Soc Trans, 2014
NRP1 also acts as a receptor for the class 3 semaphorin (SEMA3A) to regulate vessel maturation during tumour angiogenesis and vascular permeability in eye disease.
Neuropilin-1 (NRP-1) and Magnetic Nanoparticles, a Potential Combination for Diagnosis and Therapy of Gliomas.
Nanjing, China. In Curr Pharm Des, 2014
The role of NRP-1 in gliomas was explored in details, including relationships of NRP-1 expression and glioma prognosis, Sema3A-NRP-1 signaling in gliomas, NRP-1 signaling and VEGF/VEGFR、PlGF、TGF-β、PDGF、LD22-4 of FGF2、autocrine of HGF/SF、p130Cas tyrosine phosphorylation and integrin-associated tumor microenvironment in gliomas, NRP-1 intracellular trafficking, NRP-1 and glioma stem-like cells, as well as magnetic nanoparticles related to targeting gliomas.
Osteoprotection by semaphorin 3A.
Tokyo, Japan. In Nature, 2012
semaphorin 3A (Sema3A) exerts an osteoprotective effect by both suppressing osteoclastic bone resorption and increasing osteoblastic bone formation