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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Sema domain, seven thrombospondin repeats

Sema5A, Semaphorin 5A, semaphorin F, Semaf, SemF
This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010] (from NCBI)
Top mentioned proteins: HAD, CAN, POLYMERASE, SET, thrombospondin-1
Papers on Sema5A
Multigenerational autosomal dominant inheritance of 5p chromosomal deletions.
Cottrell et al., Saint Louis, United States. In Am J Med Genet A, Dec 2015
This study supports newly recognized effects of aberrant SEMA5A and CTNND2 dosage on severity of autistic and cognitive phenotypes.
Elevated Semaphorin 5A correlated with Th1 polarization in patients with chronic immune thrombocytopenia.
Yang et al., Tianjin, China. In Thromb Res, Nov 2015
Semaphorin 5A (Sema5A) has been showed to be implicated in cellular immune response.
A de novo microdeletion of SEMA5A in a boy with autism spectrum disorder and intellectual disability.
Bourgeron et al., Dijon, France. In Eur J Hum Genet, Oct 2015
Semaphorin 5A (SEMA5A) acts as a bifunctional guidance cue, exerting both attractive and inhibitory effects on developing axons.
Semaphorin 5A mediated cellular navigation: connecting nervous system and cancer.
Singh et al., Omaha, United States. In Biochim Biophys Acta, 2014
This review focuses on a novel member of this family of proteins, semaphorin 5A, which is much less explored in comparison to its other affiliates.
KIAA1199 as a potential diagnostic biomarker of rheumatoid arthritis related to angiogenesis.
Wang et al., Wenzhou, China. In Arthritis Res Ther, 2014
Moreover, KIAA1199 also enhance the proliferation and angiogenesis of synovial membrane, and KIAA1199/ PLXNB3/ SEMA5A/CTGF axis may be a newly found pathway enhancing cell proliferation and angiogenesis.
Copy number variations in a population-based study of Charcot-Marie-Tooth disease.
Russell et al., Norway. In Biomed Res Int, 2014
Three patients had potentially pathogenic CNVs in the CNTNAP2, LAMA2, or SEMA5A, that is, genes related to neuromuscular or neurodevelopmental disease.
Secreted semaphorin 5A activates immune effector cells and is a biomarker for rheumatoid arthritis.
Figueiredo et al., Hannover, Germany. In Arthritis Rheumatol, 2014
OBJECTIVE: To investigate the role of the multifunctional protein semaphorin 5A (Sema5A) in modulating cellular immune responses and as a biomarker in rheumatoid arthritis (RA).
The Plexin-B family and its role in cancer progression.
Jiang et al., Cardiff, United Kingdom. In Histol Histopathol, 2014
Plexin-B3 mediates interaction with both Sema4G and Sema5A.
Meta analysis of the association of rs7702187 SNP in SEMA5A gene with risk of Parkinson's disease.
Zhang et al., In Eur Rev Med Pharmacol Sci, 2013
AIM: The aim of our study was to derive a more precise estimation of the association between the SEMA5A rs7702187 polymorphism and the susceptibility for PD by using meta-analysis.
Attractive and permissive activities of semaphorin 5A toward dorsal root ganglion axons in higher vertebrate embryos.
Taniguchi et al., Tsukuba, Japan. In Cell Adh Migr, 2013
Here we show that class 5 semaphorin Sema5A had attractive/permissive effects on DRG axons.
Semaphorin 5A inhibits synaptogenesis in early postnatal- and adult-born hippocampal dentate granule cells.
Giger et al., Ann Arbor, United States. In Elife, 2013
Human SEMAPHORIN 5A (SEMA5A) is an autism susceptibility gene; however, its function in brain development is unknown.
Semaphorin 5A and plexin-B3 regulate human glioma cell motility and morphology through Rac1 and the actin cytoskeleton.
Lee et al., Singapore, Singapore. In Oncogene, 2012
Data show that Semaphorin 5A (Sema5A) and plexin-B3 inhibit glioma cell invasion through Rac1 inactivation.
Are Sema5a mutant mice a good model of autism? A behavioral analysis of sensory systems, emotionality and cognition.
Brown et al., Halifax, Canada. In Behav Brain Res, 2011
The results of this study concluded that the Sema5a mice do not meet the behavioral criteria for a mouse model of autism.
Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function.
Kolodkin et al., Baltimore, United States. In Neuron, 2011
Sema5A and Sema5B inhibit retinal neurite outgrowth through PlexinA1 and PlexinA3 receptors both in vitro and in vivo.
Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase.
Lee et al., Singapore, Singapore. In J Biol Chem, 2010
Data represent a novel signaling of semaphorin 5A and plexin B3 in the control of cell motility by indirect inactivation of Rac1 through RhoGDIalpha.
Identification of a novel biomarker, SEMA5A, for non-small cell lung carcinoma in nonsmoking women.
Chuang et al., Taipei, Taiwan. In Cancer Epidemiol Biomarkers Prev, 2010
The downregulation of SEMA5A in tumor tissue, both at the transcriptional and translational levels, was associated with poor survival among nonsmoking women with NSCLC.
Genetic and epigenetic alteration in gastric carcinogenesis.
Machado et al., Porto, Portugal. In Helicobacter, 2010
Several genes have been newly associated with gastric carcinogenesis, both through oncogenic activation (MYC, SEMA5A, BCL2L12, RBP2 and BUBR1) and tumor suppressor gene inactivation mechanisms (KLF6, RELN, PTCH1A, CLDN11, and SFRP5).
A genome-wide linkage and association scan reveals novel loci for autism.
Chakravarti et al., Boston, United States. In Nature, 2009
expression of SEMA5A is reduced in brains from autistic patients, further implicating SEMA5A as an autism susceptibility gene
Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics.
Isacson et al., Belmont, United States. In Trends Neurosci, 2009
The axon-guidance-pathway genes DCC, EPHB1, NTNG1, SEMA5A and SLIT3 were represented by SNPs predicting PD outcomes.
Cri du Chat syndrome.
Cerruti Mainardi, Vercelli, Italy. In Orphanet J Rare Dis, 2005
Two genes, Semaphorin F (SEMAF) and delta-catenin (CTNND2), which have been mapped to the "critical regions", are potentially involved in cerebral development and their deletion may be associated with mental retardation in CdCS patients.
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