gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Selm selenoprotein M

SelM, selenoprotein M
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized to the perinuclear structures. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ethanolaminephosphotransferase, ACID, SelK, SEPN1, Selenoprotein W
Papers on SelM
An insight into the functional role of thioredoxin reductase, a selenoprotein, in maintaining normal native microbiota in the Gulf Coast tick (Amblyomma maculatum).
New
Karim et al., Hattiesburg, United States. In Insect Mol Biol, Oct 2015
The transcriptional activity of various antioxidant genes remained unaffected whereas the antioxidant genes Manganese superoxide dismutase (MnSOD), copper/zinc superoxide dismutase (Cu/Zn SOD) and selenoprotein M (SelM) were significantly down-regulated in salivary glands of the ticks subjected to RNAi.
Selenium Deficiency Affects the mRNA Expression of Inflammatory Factors and Selenoprotein Genes in the Kidneys of Broiler Chicks.
New
Shan et al., Harbin, China. In Biol Trace Elem Res, Oct 2015
The mRNA levels of 14 selenoprotein genes (Dio1, Dio2, GPx3, Sepp1, SelH, SelI, SelK, Sepn1, SelO, SelW, Sep15, SelT, SelU, and SelS) decreased, and 9 selenoprotein genes (GPx1, GPx2, GPx4, SelPb, Txnrd1, Txnrd2, Txnrd3, SPS2, and SelM) increased in L group (p < 0.05), but the Dio3 and Sepx1 mRNA levels did not change.
Characterization of Selenoprotein M and Its Response to Selenium Deficiency in Chicken Brain.
New
Lei et al., Beijing, China. In Biol Trace Elem Res, Sep 2015
UNASSIGNED: Selenoprotein M (SelM) may function as thiol disulfide oxidoreductase that participates in the formation of disulfide bonds and can be implicated in calcium responses.
Biochemical Comparison of Commercial Selenium Yeast Preparations.
New
Murphy et al., Ireland. In Biol Trace Elem Res, Aug 2015
Using LC-MS/MS, a total of 62 Se-containing proteins were identified across four Se yeast products, displaying quantitative/qualitative changes in abundance relative to the certified reference material, SELM-1 (P value <0.05; fold change ≥2).
X-Ray fluorescence imaging and other analyses identify selenium and GPX1 as important in female reproductive function.
Harris et al., Adelaide, Australia. In Metallomics, 2015
Gene expression analysis of selenoprotein genes GPX1, GPX3, VIMP and SELM in bovine granulosa cells revealed that only GPX1 was significantly up-regulated in large healthy follicles compared to the small healthy or atretic follicles (P < 0.05).
Evaluation of the selenotranscriptome expression in two hepatocellular carcinoma cell lines.
Costantini et al., Napoli, Italy. In Anal Cell Pathol (amst), 2014
Our data showed that in both cells there are three downregulated (DIO1, DIO2, and SELO) and ten upregulated (GPX4, GPX7, SELK, SELM, SELN, SELT, SELV, SEP15, SEPW1, and TrxR1) genes.
Selenium deficiency influences nitric oxide and selenoproteins in pancreas of chickens.
Xu et al., Harbin, China. In Biol Trace Elem Res, 2014
Thioredoxin reductase 2 (TXNRD2), glutathione peroxidase 1 (GPX1), glutathione peroxidase 3 (GPX3), selenoprotein I (SELI), iodothyronine deiodinase 1 (DIO1), selenoprotein P1 (SEPP1), selenoprotein W1 (SEPW1), selenoprotein O (SELO), selenoprotein T (SELT), selenoprotein M (SELM), selenoprotein X1 (SEPX1), and SPS2 were excessively decreased (P < 0.05).
Identification of the responsible proteins for increased selenium bioavailability in the brain of transgenic rats overexpressing selenoprotein M.
Seong et al., Seoul, South Korea. In Int J Mol Med, 2014
The present study was conducted to investigate whether the high antioxidant activity induced by selenium (Sel) treatment and selenoprotein M (SelM) overexpression affected the protein profile of the brain cortex.
Transcriptional activation of antioxidants may compensate for selenoprotein deficiencies in Amblyomma maculatum (Acari: Ixodidae) injected with selK- or selM-dsRNA.
Karim et al., Hattiesburg, United States. In Insect Mol Biol, 2014
In the current work, we examined the role of selenoprotein K (SelK) and selenoprotein M (SelM) in feeding A. maculatum by bioinformatics, transcriptional gene expression, RNA interference and antioxidant assays.
Effect of selenium on selenoprotein expression in the adipose tissue of chickens.
Xu et al., Harbin, China. In Biol Trace Elem Res, 2014
This study describes the effects of selenium (Se) deficiency on the messenger ribonucleic acid (mRNA) expression of 25 selenoproteins (Sels) (including glutathione peroxidases (GPx1-GPx4), thioredoxin reductases (TrxR1-TrxR3), iodothyronine deiodinases (ID1-ID3), selenophosphate synthetase 2 (SPS2), 15-kDa Sel (Sel15), SelH, SelI, SelK, SelM, Sepn1, SelO, Sepx, Selpb, SelS, SelT, SelW, Sepp1, and SelU in the adipose tissues (subcutaneous adipose, visceral adipose, and articular adipose) of chickens.
Structure-function relationship and evolutionary history of the human selenoprotein M (SelM) found over-expressed in hepatocellular carcinoma.
Costantini et al., Napoli, Italy. In Biochim Biophys Acta, 2014
In particular, selenoprotein M (SelM) may function as thiol disulfide oxidoreductase that participates in the formation of disulfide bonds, and can be implicated in calcium responses.
Assessment of the Selenoprotein M (SELM) over-expression on human hepatocellular carcinoma tissues by immunohistochemistry.
Costantini et al., In Eur J Histochem, 2013
In particular, Selenoprotein M (SELM) is located in the endoplasmic reticulum and contains the common redox motif of cysteine-X-X-selenocysteine type.
The relationship between deiodinase activity and inflammatory responses under the stimulation of uremic toxins.
Qin et al., Nanchang, China. In J Transl Med, 2013
The presence of selenoprotein M (SelM) and DIO1 was assessed by western blotting.
The neuroprotective functions of selenoprotein M and its role in cytosolic calcium regulation.
GeneRIF
Berry et al., Honolulu, United States. In Antioxid Redox Signal, 2010
These results suggest that selenoprotein M may have an important role in protecting against oxidative damage in the brain and may potentially function in calcium regulation.
Selenoproteins and maternal nutrition.
Review
Zervas et al., Athens, Greece. In Comp Biochem Physiol B Biochem Mol Biol, 2008
Sel include but not limited to glutathione peroxidases (GPx1-GPx6), thioredoxin reductases (TrxR1-TrxR3), iodothyronine deiodinases (ID1-ID3), selenophosphate synthetase 2 (SPS2), 15-kDa Sel (Sel15), SelH, SelI, SelK, SelM, SelN, SelO, SelP, SelR, SelS, SelT, SelV, SelW, as well as the 15-kDa Sel (Fep15), SelJ and SelU found in fish.
NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family.
GeneRIF
Deisenhofer et al., Dallas, United States. In J Biol Chem, 2006
Sep15 and SelM have roles as thiol-disulfide oxidoreductases
Differentially expressed genes in transgenic mice carrying human mutant presenilin-2 (N141I): correlation of selenoprotein M with Alzheimer's disease.
GeneRIF
Kim et al., Seoul, South Korea. In Neurochem Res, 2005
mouse SelM had significantly suppressed on its transcriptional products in transgenic brains
Genomics perspective on disulfide bond formation.
Review
Gladyshev et al., Lincoln, United States. In Antioxid Redox Signal, 2003
Emerging evidence suggests that these ER functions might be assisted by mammalian selenocysteine-containing oxidoreductases Sep15 and SelM.
share on facebooktweetadd +1mail to friends