Selenium speciation in paired serum and cerebrospinal fluid samples of sheep.
Hannover, Germany. In J Trace Elem Med Biol, Jan 2016
IEC-ICP-DRC-MS technique was able to differentiate the Se species selenoprotein P-bound Se (SePP), selenomethionine, glutathione peroxidase-bound Se (Se-GPx), selenocystine, thioredoxin reductase-bound Se, ovine serum albumin-bound Se (Se-OSA), SeIV and SeVI in ovine serum and CSF.
Effect of Inorganic Dietary Selenium Supplementation on Selenoprotein and Lipid Metabolism Gene Expression Patterns in Liver and Loin Muscle of Growing Lambs.
Poland. In Biol Trace Elem Res, Jan 2016
Significant differences were found in the expression of GPX1, GPX2, SEPM, SEPW1, SEP15, SEPGS2, and TXNRD1 in the liver, and GPX1, SEPP1, SEPN1, SEPW1, SEP15, and MSRB1 in the LD muscle between S and C lambs.
Pro198Leu polymorphism affects the selenium status and GPx activity in response to Brazil nut intake.
Melbourne, Australia. In Food Funct, Jan 2016
Here, we have conducted a pilot study that examined the effects of a range of single nucleotide polymorphisms (SNPs) in genes encoding the selenoproteins glutathione peroxidase (GPX1) and selenoprotein P (SEPP) in response to selenium supplementation via dietary Brazil nuts, including selenium status, oxidative stress parameters and GPX1 and SEPP gene expression.
Redox regulation of FoxO transcription factors.
Jena, Germany. In Redox Biol, Dec 2015
superoxide dismutase-2, peroxiredoxins 3 and 5) and peroxisomes (catalase), as well as for antioxidant proteins found extracellularly in plasma (e.g., selenoprotein P and ceruloplasmin).
Revised reference values for selenium intake.
Potsdam, Germany. In J Trace Elem Med Biol, Oct 2015
The saturation of selenoprotein P (SePP) in plasma is used as a criterion for the derivation of reference values for selenium intake in adults.
Selenium and the thyroid.
Berlin, Germany. In Curr Opin Endocrinol Diabetes Obes, Oct 2015
SUMMARY: Adequate nutritional supply of selenium that saturates expression of circulating selenoprotein P, together with optimal iodine and iron intake, is required for a healthy and functional thyroid during development, adolescence, adulthood and aging.
Biomarkers of selenium status.
Grand Forks, United States. In Nutrients, Apr 2015
Some Se-biomarkers, such as the selenoproteins and particularly GPX3 and SEPP1, provide information about function directly and are of value in identifying nutritional Se deficiency and tracking responses of deficient individuals to Se-treatment.
Regulation of Selenium Metabolism and Transport.
Nashville, United States. In Annu Rev Nutr, 2014
It responds to selenium deficiency by curtailing excretion and secreting selenoprotein P (Sepp1) into the plasma at the expense of its intracellular selenoproteins.