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24-dehydrocholesterol reductase

seladin-1, DHCR24, 24-dehydrocholesterol reductase
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, HAD, STEP, PrP
Papers on seladin-1
Seladin-1/DHCR24 Is Neuroprotective by Associating EAAT2 Glutamate Transporter to Lipid Rafts in Experimental Stroke.
Moro et al., Madrid, Spain. In Stroke, Jan 2016
BACKGROUND AND PURPOSE: 3β-Hydroxysteroid-Δ24 reductase (DHCR24) or selective alzheimer disease indicator 1 (seladin-1), an enzyme of cholesterol biosynthetic pathway, has been implicated in neuroprotection, oxidative stress, and inflammation.
Stimulation of Na(+),K(+)-ATPase Activity as a Possible Driving Force in Cholesterol Evolution.
Clarke et al., Sydney, Australia. In J Membr Biol, Jan 2016
To test this hypothesis, mirror tree and phylogenetic distribution analyses have been conducted of the Na(+),K(+)-ATPase and 3β-hydroxysterol Δ(24)-reductase (DHCR24), the last enzyme in the Bloch cholesterol biosynthetic pathway.
Brain Cholesterol Synthesis and Metabolism is Progressively Disturbed in the R6/1 Mouse Model of Huntington's Disease: A Targeted GC-MS/MS Sterol Analysis.
Jenner et al., Wollongong, Australia. In J Huntingtons Dis, Dec 2015
Elevated levels of desmosterol, a substrate of delta(24)-sterol reductase (DHCR24), were also detected in R6/1 mice at the end time-point.
Protective Effect of DHT on Apoptosis Induced by U18666A via PI3K/Akt Signaling Pathway in C6 Glial Cell Lines.
Zu et al., Shanghai, China. In Cell Mol Neurobiol, Oct 2015
Expression of apoptosis-related proteins, such as Akt, seladin-1, Bcl-2 family proteins, and caspase-3, was determined using Western blot.
Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum.
Blobel et al., New York City, United States. In Nature, 2015
Sterol reductases including Δ(14)-sterol reductase (C14SR, also known as TM7SF2), 7-dehydrocholesterol reductase (DHCR7) and 24-dehydrocholesterol reductase (DHCR24) reduce specific carbon-carbon double bonds of the sterol moiety using a reducing cofactor during sterol biosynthesis.
The Effect of Statins on Blood Gene Expression in COPD.
Sin et al., Vancouver, Canada. In Plos One, 2014
RESULTS: 25 genes were differentially expressed between statin users and non-users at an FDR of 10%, including LDLR, CXCR2, SC4MOL, FAM108A1, IFI35, FRYL, ABCG1, MYLIP, and DHCR24.
MicroRNAs: a connection between cholesterol metabolism and neurodegeneration.
Fernández-Hernando et al., New Haven, United States. In Neurobiol Dis, 2014
Specifically, genes involved in cholesterol biosynthesis (24-dehydrocholesterol reductase, DHCR24) and cholesterol efflux (ATP-binding cassete transporter, ABCA1, and apolipoprotein E, APOE) have been associated with developing Alzheimer's disease.
Navigating the Shallows and Rapids of Cholesterol Synthesis Downstream of HMGCR.
Brown et al., Australia. In J Nutr Sci Vitaminol (tokyo), 2014
In this review, we discuss the transcriptional regulation of the two terminal enzymes, 7- and 24-dehydrocholesterol reductase (DHCR7 and DHCR24), where we have found that a cooperative transcriptional program exists.
Investigation into the effects of antioxidant-rich extract of Tamarindus indica leaf on antioxidant enzyme activities, oxidative stress and gene expression profiles in HepG2 cells.
Mat Junit et al., Kuala Lumpur, Malaysia. In Peerj, 2014
The expression of KNG1, SERPINC1, SERPIND1, SERPINE1, FGG, FGA, MVK, DHCR24, CYP24A1, ALDH6A1, EPHX1 and LEAP2 were amongst the highly regulated.
Cholesterol precursors: more than mere markers of biosynthesis.
Olkkonen et al., Sydney, Australia. In Curr Opin Lipidol, 2014
Secondly, we explore the interplay between cholesterol precursors (7-dehydrocholesterol and desmosterol) and the enzymes that act upon them (DHCR7 and DHCR24) in the context of liver disease.
Desmosterol and DHCR24: unexpected new directions for a terminal step in cholesterol synthesis.
Brown et al., Sydney, Australia. In Prog Lipid Res, 2013
3β-Hydroxysterol Δ(24)-reductase (DHCR24) catalyzes the conversion of desmosterol to cholesterol.
Steroidal triterpenes of cholesterol synthesis.
Rozman et al., Ljubljana, Slovenia. In Molecules, 2012
Due to the structural similarities of sterol intermediates and the broad substrate specificity of the enzymes involved (especially sterol-Δ24-reductase; DHCR24) the exact sequence of the reactions between lanosterol and cholesterol remains undefined.
Alzheimer's disease: neuroprogesterone, epoxycholesterol, and ABC transporters as determinants of neurodesmosterol tissue levels and its role in amyloid protein processing.
Javitt, New York City, United States. In J Alzheimers Dis, 2012
The concept arose from the recognition that dehydrocholesterol 24-reductase (DHCR24/Seladin-1), one of the nine enzymes in the endoplasmic reticulum that determines the transformation of lanosterol to cholesterol, is selectively reduced in late AD.
Heme oxygenase effect on mesenchymal stem cells action on experimental Alzheimer's disease.
Alkaffas et al., Cairo, Egypt. In Excli J, 2012
Brain tissue was collected for HO-1, seladin-1 gene expression by real time polymerase chain reaction, heme oxygenase activity, cholesterol estimation and histopathological examination.
Hepatitis C virus promotes expression of the 3β-hydroxysterol δ24-reductase through Sp1.
Tsukiyama-Kohara et al., Kumamoto, Japan. In J Med Virol, 2012
Activation of Sp1 by oxidative stress is involved in the promotion of expression of DHCR24 by Hepatitis C virus.
3β-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species.
Seo et al., Kasugai, Japan. In J Bone Miner Metab, 2012
This is the first demonstration that DHCR24 plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species.
Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.
Alzheimer’s Disease Neuroimaging Initiative et al., Indianapolis, United States. In Brain Imaging Behav, 2012
Level of brain amyloid deposition on [(11)C]PiB PET was associated with rs7551288, an intronic SNP in DHCR24, in 103 participants. The minor allele was associated with lower PiB uptake with non-carriers showing higher PiB uptake in frontal regions.
The membrane topological analysis of 3β-hydroxysteroid-Delta24 reductase (DHCR24) on endoplasmic reticulum.
Gao et al., Shenyang, China. In J Mol Endocrinol, 2012
DHCR24-overexpressed cells were protected from apoptosis in response to oxidative stress, which was accompanied by a decrease in DHCR24 content on the ER and activation of caspase-3.
Simvastatin modulates the Alzheimer's disease-related gene seladin-1.
Burgos et al., Granada, Spain. In J Alzheimers Dis, 2011
This study describes Simvastatin modulates the Alzheimer's disease-related gene seladin-1.
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1.
Galaktionov et al., Houston, United States. In Nature, 2005
identification, using a direct genetic screen, Seladin-1 (also known as Dhcr24) as a key mediator of Ras-induced senescence
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