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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

24-dehydrocholesterol reductase

seladin-1, DHCR24, 24-dehydrocholesterol reductase
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on seladin-1
Hepatitis C virus promotes expression of the 3β-hydroxysterol δ24-reductase through Sp1.
GeneRIF
Tsukiyama-Kohara et al., Kumamoto, Japan. In J Med Virol, 2012
Activation of Sp1 by oxidative stress is involved in the promotion of expression of DHCR24 by Hepatitis C virus.
3β-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species.
GeneRIF
Seo et al., Kasugai, Japan. In J Bone Miner Metab, 2012
This is the first demonstration that DHCR24 plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species.
Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.
GeneRIF
Alzheimer’s Disease Neuroimaging Initiative et al., Indianapolis, United States. In Brain Imaging Behav, 2012
Level of brain amyloid deposition on [(11)C]PiB PET was associated with rs7551288, an intronic SNP in DHCR24, in 103 participants. The minor allele was associated with lower PiB uptake with non-carriers showing higher PiB uptake in frontal regions.
The membrane topological analysis of 3β-hydroxysteroid-Delta24 reductase (DHCR24) on endoplasmic reticulum.
GeneRIF
Gao et al., Shenyang, China. In J Mol Endocrinol, 2012
DHCR24-overexpressed cells were protected from apoptosis in response to oxidative stress, which was accompanied by a decrease in DHCR24 content on the ER and activation of caspase-3.
Simvastatin modulates the Alzheimer's disease-related gene seladin-1.
GeneRIF
Burgos et al., Granada, Spain. In J Alzheimers Dis, 2011
This study describes Simvastatin modulates the Alzheimer's disease-related gene seladin-1.
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