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Transcription factor CP2

SEF, CP2, LBP-1c, transcription factor LSF
This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, V1a, OUT
Papers on SEF
Coordination Polymers Derived from Non-Steroidal Anti-Inflammatory Drugs for Cell Imaging and Drug Delivery.
Dastidar et al., Seychelles. In Chemistry, Jan 2016
A new series of Mn(II) coordination polymers, namely, [{Mn(L)(H2 O)2 }⋅2 Nap]∞ (CP1), [{Mn(L)(Ibu)2 (H2 O)2 }]∞ (CP2), [{Mn(L)(Flr)2 (H2 O)2 }]∞ (CP3), [{Mn(L)(Ind)2 (H2 O)2 }⋅H2 O]∞ (CP4), [{Mn2 (L)2 (μ-Flu)4 (H2 O)}⋅L]∞ (CP5), [{Mn2 (L)2 (μ-Tol)4 (H2 O)2 }]∞ (CP6) and [{Mn2 (L)2 (μ-Mef)4 (H2 O)2 }]∞ (CP7) (Nap=naproxen, Ibu=ibuprofen, Flr=flurbiprofen, Ind=indometacin, Flu=flufenamic acid, Tol=tolfenamic acid and Mef=mefenamic acid) derived from various non-steroidal anti-inflammatory drugs (NSAIDs) and the organic linker 1,2-bis(4-pyridyl)ethylene (L) have been synthesized with the aim of being used for cell imaging and drug delivery.
Bis-cyclopropane analog of disorazole C1 is a microtubule-destabilizing agent active in ABCB1-overexpressing human colon cancer cells.
Schmitz et al., Pittsburgh, United States. In Oncotarget, Jan 2016
The novel, chemically stabilized disorazole analog, (-)-CP2-disorazole C1 (1) displayed potent anti-proliferative activity against a broad-spectrum of human colorectal cancer cells.
Anteaglonialides A-F and Palmarumycins CE1-CE3 from Anteaglonium sp. FL0768, a Fungal Endophyte of the Spikemoss Selaginella arenicola.
Gunatilaka et al., Tucson, United States. In J Nat Prod, Dec 2015
Anteaglonialides A-F (1-6), bearing a spiro[6-(tetrahydro-7-furanyl)cyclohexane-1,2'-naphtho[1,8-de][1,3]-dioxin]-10-one skeleton, three new spirobisnaphthalenes, palmarumycins CE1-CE3 (7-9), nine known palmarumycin analogues, palmarumycins CP5 (10), CP4a (11), CP3 (12), CP17 (13), CP2 (14), and CP1 (15), CJ-12,371 (16), 4-O-methyl CJ-12,371 (17), and CP4 (18), together with a possible artifact, 4a(5)-anhydropalmarumycin CE2 (8a), and four known metabolites, O-methylherbarin (19), herbarin (20), herbaridine B (21), and hyalopyrone (22), were encountered in a cytotoxic extract of a potato dextrose agar culture of Anteaglonium sp.
Transcription factor LSF (TFCP2) inhibits melanoma growth.
Kato et al., Kasugai, Japan. In Oncotarget, Nov 2015
UNASSIGNED: Late SV40 factor 3 (LSF), a transcription factor, contributes to human hepatocellular carcinoma (HCC).
The role of supplementary eye field in goal-directed behavior.
Stuphorn, Baltimore, United States. In J Physiol Paris, Feb 2015
The supplementary eye field (SEF) is a cortical area within medial frontal cortex that is involved in the regulation of eye movements.
Primary sclerosing epithelioid fibrosarcoma of kidney with variant histomorphologic features: report of 2 cases and review of the literature.
Aki et al., Ankara, Turkey. In Diagn Pathol, 2014
The authors present two cases of primary sclerosing epithelioid fibrosarcoma (SEF) of the kidney.
A Transcriptomic Study of Maternal Thyroid Adaptation to Pregnancy in Rats.
Fu et al., Guangzhou, China. In Int J Mol Sci, 2014
In addition, by examining of the promoter regions of up-regulated genes, we identified MAZ (MYC-associated zinc finger protein) and TFCP2 (transcription factor CP2) as two causal transcription factors.
Screening of Transcription Factors Involved in Fetal Hemoglobin Regulation Using Phylogenetic Footprinting.
Bonini-Domingos et al., Ribeirão Preto, Brazil. In Evol Bioinform Online, 2014
Of these motifs, 13 showed relation to Hb F regulation: cell division cycle-5 (CDC5), myelo-blastosis viral oncogene homolog (c-MYB), transcription factor CP2 (TFCP2), GATA binding protein 1 (GATA-1), GATA binding protein 2 (GATA-2), nuclear factor erythroid 2 (NF-E2), nuclear transcription factor Y (NF-Y), runt-related transcription factor 1 (RUNX-1), T-cell acute lymphocytic leukemia 1 (TAL-1), YY1 transcription factor (YY1), beta protein 1 (BP1), chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII), and paired box 1 (PAX-1).
Characterization of Golgi scaffold proteins and their roles in compartmentalizing cell signaling.
Hu et al., Changsha, China. In J Mol Histol, 2014
Sef, PAQR3, PAQR10 and PAQR11 are scaffold proteins that have recently been identified on the GA and are referred to as Golgi scaffolds.
TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease.
Collier et al., London, United Kingdom. In Am J Med Genet B Neuropsychiatr Genet, 2013
Common SNPs in the transcription factor 4 (TCF4; ITF2, E2-2, SEF-2) gene, which encodes a basic Helix-Loop-Helix (bHLH) transcription factor, are associated with schizophrenia, conferring a small increase in risk.
Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma.
Hansen et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma
Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation.
Meloche et al., Montréal, Canada. In Cancer Res, 2012
Findings indicate that Ras-induced nuclear accumulation of activated MEK1/2 was reliant on downregulation of the spatial regulator Sef.
Recent advances in liver sinusoidal endothelial ultrastructure and fine structure immunocytochemistry.
Hibi et al., Saitama, Japan. In Micron, 2012
We investigated actin filaments in relation to SEF in LSECs using a heavy meromyosin-decorated reaction and thereby elucidated the roles of small G protein and actin cytoskeleton in the morphological and functional alterations of SEF.
Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9).
Sarkar et al., Richmond, United States. In J Biol Chem, 2012
Inhibition of MMP-9 significantly abrogated LSF-induced angiogenesis as well as in vivo tumorigenesis, thus reinforcing the role of MMP-9 in facilitating LSF function.
c-Met activation through a novel pathway involving osteopontin mediates oncogenesis by the transcription factor LSF.
Sarkar et al., Richmond, United States. In J Hepatol, 2011
Secreted OPN, induced by LSF, activates c-Met via a potential interaction between OPN and its cell surface receptor CD44. A significant correlation was observed among LSF, OPN, and activated c-Met levels in HCC.
Late SV40 factor: a key mediator of Notch signaling in human hepatocarcinogenesis.
Chen et al., Nanjing, China. In World J Gastroenterol, 2011
Data suggest that LSF is a key mediator of the Notch1 signaling pathway, suggesting that it might be a novel therapeutic target for the treatment of hepatocellular carcinoma.
Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling.
Thisse et al., Strasbourg, France. In Nat Cell Biol, 2002
On the basis of similarities in their expression patterns during embryonic development, we have identified five genes that define a synexpression group -- fgf8, fgf3, sprouty2, sprouty4, as well as a novel gene, sef (similar expression to fgf genes).
Identification of Sef, a novel modulator of FGF signalling.
Dawid et al., Bethesda, United States. In Nat Cell Biol, 2002
Here we report the identification of a novel modulator of FGF signal transduction, sef, isolated from a zebrafish embryo library through an in situ hybridization screen.
Human CCAAT-binding proteins have heterologous subunits.
Sharp et al., Cambridge, United States. In Cell, 1988
A second protein, CP2, binds with high affinity to a CCAAT element present in the rat gamma-fibrinogen promoter.
A new staphylococcal enterotoxin, enterotoxin F, associated with toxic-shock-syndrome Staphylococcus aureus isolates.
Davis et al., In Lancet, 1981
612 (93.8%) of 65 Staphylococcus aureus strains isolated from 65 patients with toxic-shock syndrome (TSS) produced an enterotoxin-like protein, tentatively identified as staphylococcal enterotoxin F (SEF).
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