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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Secretogranin II

secretogranin II, SgII, Secretoneurin, chromogranin C
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Neuropeptide, ACID, chromogranin A, chromogranin B, CAN
Papers using secretogranin II antibodies
The PC6B cytoplasmic domain contains two acidic clusters that direct sorting to distinct trans-Golgi network/endosomal compartments
Krantz David E. et al., In The Journal of Cell Biology, 1999
... from Covance, the rat monoclonal hemagglutinin (HA) antibody from Boehringer, the rabbit polyclonal antiserum to secretogranin II from BioDesign, the mouse monoclonal antibody ...
Papers on secretogranin II
PROX1 promotes secretory granule formation in medullary thyroid cancer cells.
Kamma et al., Kami-renjaku, Japan. In Endocrinology, Feb 2016
Knockdown of PROX1 in an MTC cells reduced SGs detected by electron microscopy, and decreased expression of SG-related genes (Chromogranin A, Chromogranin B, Secretogranin II, Secretogranin III, Synaptophysin and Carboxypeptidase E).
Differential Reovirus-Specific and Herpesvirus-Specific Activator Protein 1 Activation of Secretogranin II Leads to Altered Virus Secretion.
Coombs et al., Winnipeg, Canada. In J Virol, Jan 2016
The nonenveloped RNA reoviruses caused an upregulation, whereas the enveloped DNA HSV-1 caused a downregulation, of cellular secretogranin II (SCG2).
REST Regulates Non-Cell-Autonomous Neuronal Differentiation and Maturation of Neural Progenitor Cells via Secretogranin II.
Kagalwala et al., Boston, United States. In J Neurosci, Dec 2015
Gene expression analysis identified Secretogranin II (Scg2) as the major secreted REST target responsible for the non-cell-autonomous phenotype.
The secretogranin-II derived peptide secretoneurin modulates electric behavior in the weakly pulse type electric fish, Brachyhypopomus gauderio.
Trudeau et al., Montevideo, Uruguay. In Gen Comp Endocrinol, Nov 2015
Secretoneurin (SN) in the preoptic area and pituitary of mammals and fish has a conserved close association with the vasopressin and oxytocin systems, members of a peptide family that are key in the modulation of sexual and social behaviors.
Co-storage and secretion of growth hormone and secretoneurin in retinal ganglion cells.
Harvey et al., Edmonton, Canada. In Gen Comp Endocrinol, Oct 2015
In this work we demonstrate for the first time that GH- and secretoneurin (SN) immunoreactivity (the secretogranin II (SgII) fragment) are similarly present in retinal ganglion cells (RGCs), which is an extrapituitary site of GH expression, and in quail QNR/D cells, which provide an experimental RGC model.
Sudomotor innervation in transthyretin amyloid neuropathy: Pathology and functional correlates.
Hsieh et al., Taipei, Taiwan. In Ann Neurol, Aug 2015
Sudomotor innervation was stained with 2 markers: protein gene product 9.5 (PGP 9.5), a general neuronal marker, and vasoactive intestinal peptide (VIP), a sudomotor nerve functional marker, followed by quantitation according to sweat gland innervation index (SGII) for PGP 9.5 (SGIIPGP 9.5) and VIP (SGIIVIP).
Impact of aflatoxin B1 on hypothalamic neuropeptides regulating feeding behavior.
Magoul et al., Fès, Morocco. In Neurotoxicology, Jul 2015
We also studied the effect of AFB1 on a novel neuropeptide, the secretogranin II (SgII)-derived peptide EM66, which has recently been linked to the control of food intake.
Secretoneurin is a novel prognostic cardiovascular biomarker associated with cardiomyocyte calcium handling.
Røsjø et al., Norway. In J Am Coll Cardiol, Mar 2015
BACKGROUND: Secretoneurin (SN) levels are increased in patients with heart failure (HF), but whether SN provides prognostic information and influences cardiomyocyte function is unknown.
Immune responses elicited against rotavirus middle layer protein VP6 inhibit viral replication in vitro and in vivo.
Blazevic et al., Tampere, Finland. In Hum Vaccin Immunother, 2013
In order to determine neutralizing activity of fecal samples, sera, and vaginal washes (VW) against human Wa RV (SGII, G1P1A[8]) and rhesus RV (SGI, G3P5B[3]), the RV antigen production was measured with an ELISA-based antigen reduction neutralization assay.
Differential expression and processing of secretogranin II in relation to the status of pheochromocytoma: implications for the production of the tumoral marker EM66.
Yon et al., Mont-Saint-Aignan, France. In J Mol Endocrinol, 2012
Data describe the gene expression and protein production of SgII in normal adrenal glands and pheochromocytomas with the goal to examine the molecular mechanisms leading to the marked variations in the expression of EM66 in tumoral chromaffin tissue.
Is secretoneurin a new hormone?
Basak et al., Ottawa, Canada. In Gen Comp Endocrinol, 2012
Numerous small potentially bioactive peptides are derived from the selective processing of the ~600 amino acid secretogranin II (SgII) precursor, but only the 31-42 amino acid segment termed secretoneurin (SN) is well-conserved from sharks to mammals.
Peptides released by physiological cleavage of semen coagulum proteins form amyloids that enhance HIV infection.
Greene et al., San Francisco, United States. In Cell Host Microbe, 2012
Peptides released by physiological cleavage of Semg1 and Semg2 form amyloids that enhance HIV infection.
Monocular enucleation profoundly reduces secretogranin II expression in adult mouse visual cortex.
Arckens et al., Leuven, Belgium. In Neurochem Int, 2011
it was proven that ScgII cannot be categorized as an activity marker, but more likely plays a role in visual system plasticity by modulating a range of neurotransmitters and neuropeptides
Secretogranin II; a protein increased in the myocardium and circulation in heart failure with cardioprotective properties.
Christensen et al., Norway. In Plos One, 2011
SgII mRNA levels were 10.5 fold upregulated in the left ventricle of animals with myocardial infarction and heart failure.
The extended granin family: structure, function, and biomedical implications.
Salton et al., Minneapolis, United States. In Endocr Rev, 2011
The chromogranins (chromogranin A and chromogranin B), secretogranins (secretogranin II and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) that together comprise the granin family subserve essential roles in the regulated secretory pathway that is responsible for controlled delivery of peptides, hormones, neurotransmitters, and growth factors.
Expression of semenogelins I and II and its prognostic significance in human prostate cancer.
Miyamoto et al., Rochester, United States. In Prostate, 2011
These results suggest the involvement of semenogelins in prostate cancer and their prognostic values in predicting cancer progression after radical prostatectomy.
Inositol 1,4,5-trisphosphate receptor in chromaffin secretory granules and its relation to chromogranins.
Hur et al., Inch'ŏn, South Korea. In Cell Mol Neurobiol, 2010
Moreover, secretory granules contain large amounts (2-4 mM) of chromogranins and secretogranins; chromogranins A and B, and secretogranin II being the major species.
Immunohistochemical and biochemical studies with region-specific antibodies to chromogranins A and B and secretogranins II and III in neuroendocrine tumors.
Stridsberg et al., Lisbon, Portugal. In Cell Mol Neurobiol, 2010
This short review deals with investigations in neuroendocrine tumors (NETs) with antibodies against defined epitopes of chromogranins (Cgs) A and B and secretogranins (Sgs) II and III.
Granins as disease-biomarkers: translational potential for psychiatric and neurological disorders.
Salton et al., Parma, Italy. In Neuroscience, 2010
This article discusses the biomarker potential of the granin family, a group of acidic proteins present in the secretory granules of a wide variety of endocrine, neuronal and neuroendocrine cells: chromogranin A (CgA), CgB, Secretogranin II (SgII), SgIII, HISL-19 antigen, 7B2, NESP55, VGF and ProSAAS.
Cell-free protein sorting to the regulated and constitutive secretory pathways.
Huttner et al., Heidelberg, Germany. In Cell, 1990
To elucidate the mechanism of secretory granule formation, we here identify the first intermediate in this process, the immature secretory granule, in the neuroendocrine cell line PC12 and demonstrate the packaging of a regulated secretory protein, secretogranin II, to immature secretory granules in a cell-free system.
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