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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


Secretin belongs to the glucagon family. This protein is an endocrine hormone and its major site of production is the endocrine S cells located in the proximal small intestinal mucosa. The release of active secretin is stimulated by either fatty acids or an acidic pH in the duodenum. This hormone stimulates the secretion of bicarbonate-rich pancreatic fluids and has also been shown to regulate the growth and development of the stomach, small intestine, and pancreas. Secretin deficiency has been implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, Glucagon, Cholecystokinin
Papers using Secretin antibodies
The potential usefulness of taurine on diabetes mellitus and its complications.
Tordjmann Thierry, In PLoS ONE, 2010
... Meanwhile, a bolus of rat secretin (RayBiotech; 40 nmol) was infused ...
CHIP28 water channels are localized in constitutively water-permeable segments of the nephron
Alpini Gianfranco et al., In Laboratory investigation; a journal of technical methods and pathology, 1992
... The secretin receptor (C-20) is an affinity purified goat polyclonal antibody (Santa Cruz Biotechnology Inc., Santa Cruz, CA) ...
Papers on Secretin
Integrative Approaches to Caring for Children with Autism.
Kemper et al., Columbus, United States. In Curr Probl Pediatr Adolesc Health Care, Feb 2016
Given their risks, costs, and limited evidence of efficacy, chelation, secretin, and hyperbaric oxygen should be avoided.
Use of cysteine trapping to map spatial approximations between residues contributing to the helix N-capping motif of secretin and distinct residues within each of the extracellular loops of its receptor.
Miller et al., United States. In J Biol Chem, Feb 2016
UNASSIGNED: Amino-terminal regions of secretin-family peptides contain key determinants for biological activity and binding specificity, although the nature of interactions with receptors is unclear.
Validation of SCT Methylation As a Hallmark Biomarker for Lung Cancers.
Gazdar et al., Dallas, United States. In J Thorac Oncol, Jan 2016
INTRODUCTION: The human secretin gene (SCT) encodes secretin, a hormone with limited tissue distribution.
The involvement of the PilQ secretin of type IV pili in phage infection in Ralstonia solanacearum.
Yamada et al., Hiroshima, Japan. In Biochem Biophys Res Commun, Jan 2016
UNASSIGNED: PilQ is a member of the secretin family of outer membrane proteins and specifically involved in type IV secretion.
GLP-1 receptor agonist exenatide has no acute effect on MRI-measured exocrine pancreatic function in type 2 diabetes patients: a randomised trial.
Cahen et al., Amsterdam, Netherlands. In Diabetes Obes Metab, Jan 2016
Exocrine pancreatic function was measured using secretin-enhanced magnetic resonance cholangiopancreatography (s-MRCP).
Is Oxytocin Application for Autism Spectrum Disorder Evidence-Based?
Bahn et al., Seoul, South Korea. In Exp Neurobiol, Dec 2015
Studies on candidate medications related to the pathogenesis of ASD, such as naltrexone and secretin, were conducted, but the results were inconclusive.
Characterization of MDAΦ, a temperate filamentous bacteriophage of Neisseria meningitidis.
Bille et al., Paris, France. In Microbiology, Dec 2015
Subsequent molecular investigations showed that the MDA island has indeed the characteristics of a filamentous prophage which can enter into a productive cycle and is secreted using the type IV pilus (tfp) secretin PilQ.
Novel tactics for neuroprotection in Parkinson's disease: Role of antibiotics, polyphenols and neuropeptides.
Raisman-Vozari et al., Pécs, Hungary. In Prog Neurobiol, Dec 2015
Among them, pituitary adenylate cyclase-activating polypeptide, a member of the secretin/glucagon superfamily, has several advantageous effects in models of neurodegeneration, namely anti-apoptotic, anti-inflammatory and antioxidant actions, the combination of which offers a potent protective effect in dopaminergic neurons.
Directed differentiation of cholangiocytes from human pluripotent stem cells.
Ghanekar et al., Toronto, Canada. In Nat Biotechnol, Aug 2015
Using three-dimensional culture, the protocol yields cystic and/or ductal structures that express mature biliary markers, including apical sodium-dependent bile acid transporter, secretin receptor, cilia and cystic fibrosis transmembrane conductance regulator (CFTR).
Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation.
Vallier et al., Cambridge, United Kingdom. In Nat Biotechnol, Aug 2015
CLCs show functional characteristics of cholangiocytes, including bile acids transfer, alkaline phosphatase activity, γ-glutamyl-transpeptidase activity and physiological responses to secretin, somatostatin and vascular endothelial growth factor.
Pancreatic polypeptide: a review of its involvement in neuro-endocrine reflexes, islet-acinar interactions and ethanol-evoked physiopatologic pancreatic gland changes.
Tiscornia-Wasserman et al., In Acta Gastroenterol Latinoam, Jun 2015
As the PP secretion, normally elicited by secretin, CCK, food and insulin hypoglycemia, is depressed in the presence of an augmented number of PP cells, as it is in the cases of chronic alcoholics, cystic fibrosis patients and, also, in dogs with pancreatic fibrosis (ductal ligation), it has been inferred, besides our postulated impairment of the Pavlov inhibitory fibers in the vagus nerves, that the defect of PP release is localized to the common final pathway of the above stimuli, probably in or near the PP cell itself This review was prompted by the unexpected experimental finding in canines that Tissucol-induced pancreatic ductal blockade elicits Pancreatic Polypeptide (PP) release and seems to be at the basis of the beneficial effects on taurocho- late-induced acute pancreatitis (AP).
Hormone and Receptor Candidates for Target and Biotherapy of Neuroendocrine Tumors.
Ferone et al., Rotterdam, Netherlands. In Front Horm Res, 2014
receptors for GLP-1, CCK, GRP, secretin and dopamine) can be expressed at a high density in NETs.
Cellular mechanisms and behavioral consequences of Kv1.2 regulation in the rat cerebellum.
Morielli et al., Burlington, United States. In J Neurosci, 2012
Secretin decreases cell surface Kv1.2 alpha-subunit levels by modulating Kv1.2 alpha- subunit endocytic trafficking.
Secretin is not necessary for exocrine pancreatic development and growth in mice.
Williams et al., Ann Arbor, United States. In Am J Physiol Gastrointest Liver Physiol, 2011
secretin is not required for normal pancreatic development or adaptive growth mediated by CCK.
Global hormone profiling of murine placenta reveals Secretin expression.
Baker et al., Stanford, United States. In Placenta, 2011
The characteristics of Secretin fit the paradigm of known placental hormones and suggest that it may play an important role during pregnancy.
Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist.
Miller et al., Scottsdale, United States. In Biochemistry, 2011
binding and activity of a series of 11 truncated and lactam-constrained secretin(5-27) analogues at the prototypic member of this family, the secretin receptor
Ursodeoxycholic acid is conjugated with taurine to promote secretin-stimulated biliary hydrocholeresis in the normal rat.
Banales et al., Pamplona, Spain. In Plos One, 2010
Ursodeoxycholic acid is conjugated in order to promote secretin-stimulated hydrocholeresis in rats through Ae2, microtubules, intracellular Ca(2+), PKCalpha, PI3K, PKA, and MEK.
Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery.
Vaudry et al., Mont-Saint-Aignan, France. In Pharmacol Rev, 2009
PACAP belongs to the vasoactive intestinal polypeptide (VIP)-secretin-growth hormone-releasing hormone-glucagon superfamily.
Enterogastrone inhibits eating by fasted mice.
Meyer et al., In Science, 1967
Other peptides prepared from hog duodenum or colon, as well as glucagon, secretin, glucose, and bovine serum albumin, were ineffective.
Ivy et al., In Science, 1944
It is separated from secretin by precipitation with aniline, and stimulates equally the formation of the three chief pancreatic enzymes; it is inactivated by incubation with serum, probably on an enzyme basis.
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