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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Secretin receptor

secretin receptor, SCTR
The protein encoded by this gene is a G protein-coupled receptor and belongs to the glucagon-VIP-secretin receptor family. It binds secretin which is the most potent regulator of pancreatic bicarbonate, electrolyte and volume secretion. Secretin and its receptor are suggested to be involved in pancreatic cancer and autism. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Secretin, ACID, HAD, Vasoactive Intestinal Peptide, Glucagon
Papers on secretin receptor
Development and functional characterization of extrahepatic cholangiocyte lines from normal rats.
New
Alpini et al., Temple, United States. In Dig Liver Dis, Nov 2015
At ∼85% confluence, in extrahepatic cholangiocytes we measured: (i) cell size and distribution, and expression for cytokeratin-19, secretin, secretin receptor and somatostatin receptor type II (SSTR2), cystic fibrosis transmembrane conductance regulator (CFTR), chloride bicarbonate anion exchanger 2 (AE2), vascular endothelial growth factor-A (VEGF-A) and nerve growth factor (NGF); and (ii) the effect of secretin and/or somatostatin on 3'-5'-cyclic adenosine monophosphate (cAMP) levels and proliferation.
SCTR regulates cell cycle-related genes toward anti-proliferation in normal breast cells while having pro-proliferation activity in breast cancer cells.
New
Kim et al., Seoul, South Korea. In Int J Oncol, Nov 2015
Secretin receptor (SCTR), the G-protein coupled receptor (GPCR) for secretin, has been observed to be upregulated in a few tumor types while downregulated in others, promoting or suppressing the proliferation of tumor cells, respectively.
Directed differentiation of cholangiocytes from human pluripotent stem cells.
New
Impact
Ghanekar et al., Toronto, Canada. In Nat Biotechnol, Aug 2015
Using three-dimensional culture, the protocol yields cystic and/or ductal structures that express mature biliary markers, including apical sodium-dependent bile acid transporter, secretin receptor, cilia and cystic fibrosis transmembrane conductance regulator (CFTR).
Secretin receptor involvement in prion-infected cells and animals.
New
Doh-ura et al., Sendai, Japan. In Febs Lett, Aug 2015
Here we show that secretin signaling via the secretin receptor regulates abnormal prion protein formation in prion-infected cells.
Fish genomes provide novel insights into the evolution of vertebrate secretin receptors and their ligand.
Power et al., Faro, Portugal. In Gen Comp Endocrinol, 2015
The secretin receptor (SCTR) is a member of Class 2 subfamily B1 GPCRs and part of the PAC1/VPAC receptor subfamily.
Cerebellar secretin modulates eyeblink classical conditioning.
Green et al., Burlington, United States. In Learn Mem, 2014
In Experiment 1, rats received intracerebellar infusions of the secretin receptor antagonist 5-27 secretin or vehicle into the lobulus simplex of cerebellar cortex immediately prior to sessions 1-3 of acquisition.
Gene expression accurately distinguishes liver metastases of small bowel and pancreas neuroendocrine tumors.
Howe et al., Iowa City, United States. In Clin Exp Metastasis, 2014
Quantitative PCR measured expression of bombesin-like receptor-3, opioid receptor kappa-1, oxytocin receptor, and secretin receptor in metastases.
Secretin receptor-knockout mice are resistant to high-fat diet-induced obesity and exhibit impaired intestinal lipid absorption.
Chow et al., Hong Kong, Hong Kong. In Faseb J, 2014
In this study, a 12 wk high-fat diet (HFD) feeding to secretin receptor-knockout (SCTR(-/-)) mice and their wild-type (SCTR(+/+)) littermates revealed that, despite similar food intake, SCTR(-/-) mice gained significantly less weight (SCTR(+/+): 49.6±0.9
Generation of functional cholangiocyte-like cells from human pluripotent stem cells and HepaRG cells.
Dubart-Kupperschmitt et al., Villejuif, France. In Hepatology, 2014
hESC- and HepaRG-derived cholangiocyte-like cells expressed markers of cholangiocytes including cytokeratin 7 and osteopontin, and the transcription factors SOX9 and hepatocyte nuclear factor 6. The cells also displayed specific proteins important for cholangiocyte functions including cystic fibrosis transmembrane conductance regulator, secretin receptor, and nuclear receptors.
Molecular evolution of GPCRs: Secretin/secretin receptors.
Review
Chow et al., Hong Kong, Hong Kong. In J Mol Endocrinol, 2014
However, the zebrafish secretin receptor was shown to be nonbioactive.
Prolonged administration of secretin to normal rats increases biliary proliferation and secretin-induced ductal secretory activity.
Glaser et al., Temple, United States. In Hepatobiliary Surg Nutr, 2014
Enhanced biliary proliferation [for example after bile duct ligation (BDL) and partial hepatectomy] is associated with increased expression of secretin receptor (SR), cystic fibrosis transmembrane conductance regulator (CFTR) and Cl(-)/HCO3 (-) anion exchanger 2 and secretin-stimulated ductal secretion, whereas loss/damage of bile ducts [for example after acute carbon tetrachloride (CCl4) administration] is associated with reduced secretin-stimulated ductal secretory activity.
The central mechanisms of secretin in regulating multiple behaviors.
Review
Chow et al., Hong Kong, Hong Kong. In Front Endocrinol (lausanne), 2013
SCT and its receptor (SCTR) are widely expressed in different brain regions, where they exert multiple cellular functions including neurotransmission, gene expression regulation, neurogenesis, and neural protection.
The physiological roles of secretin and its receptor.
Review
Glaser et al., Temple, United States. In Ann Transl Med, 2013
Secretin receptors (SR) are expressed in the basolateral domain of several cell types.
The orthosteric agonist-binding pocket in the prototypic class B G-protein-coupled secretin receptor.
Review
Dong et al., Scottsdale, United States. In Biochem Soc Trans, 2013
In this review, we focus on the prototypic secretin receptor and use extensive intrinsic photoaffinity labelling, structure-activity series, alanine-replacement mutagenesis and fluorescence analysis to define the molecular basis for this interaction.
Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: IUPHAR review 1.
Review
Said et al., Edinburgh, United Kingdom. In Br J Pharmacol, 2012
VIP and PACAP exert their actions through three GPCRs - PAC(1) , VPAC(1) and VPAC(2) - belonging to class B (also referred to as class II, or secretin receptor-like GPCRs).
Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist.
GeneRIF
Miller et al., Scottsdale, United States. In Biochemistry, 2011
binding and activity of a series of 11 truncated and lactam-constrained secretin(5-27) analogues at the prototypic member of this family, the secretin receptor
Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor.
GeneRIF
Glaser et al., L'Aquila, Italy. In Int J Cancer, 2010
results demonstrate that secretin and/or the modulation of SCTR expression might have potential as a therapeutic tool in the treatment of cholangiocarcinoma
Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor.
GeneRIF
Miller et al., Scottsdale, United States. In Biochemistry, 2010
Increasing expression of secretin receptor competes for receptor modifying protein 3 (RAMP3) association with calcitonin receptor-like receptor (CLR) to yield a functional adrenomedullin receptor.
Pattern of intra-family hetero-oligomerization involving the G-protein-coupled secretin receptor.
GeneRIF
Miller et al., Scottsdale, United States. In J Mol Neurosci, 2008
Data show that Family B G-protein-coupled receptor oligomerization occurs, with many structurally related members, such as the secretin receptor,associating with each other.
Dimerization in the absence of higher-order oligomerization of the G protein-coupled secretin receptor.
GeneRIF
Miller et al., Scottsdale, United States. In Biochim Biophys Acta, 2008
These results suggest that the secretin receptor can exist only as a structurally-specific homo-dimer, without being present as higher-order oligomers.
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