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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Secretagogin, EF-hand calcium binding protein

Secretagogin
The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: D28k, CAN, Insulin, Parvalbumin, dimethylarginine dimethylaminohydrolase
Papers on Secretagogin
Secretagogin, a hexa EF-hand calcium-binding protein: high level bacterial overexpression, one-step purification and properties.
New
Rajanikanth et al., Hyderābād, India. In Protein Expr Purif, May 2015
Secretagogin (SCGN), a hexa EF-hand calcium-binding protein, is highly expressed in the endocrine cells (especially in pancreatic islets) and in restricted neuronal sub-populations, albeit at comparatively low level.
Overexpression of secretagogin inhibits cell apoptosis and induces chemoresistance in small cell lung cancer under the regulation of miR-494.
Guo et al., Guangzhou, China. In Oncotarget, 2014
Secretagogin (SCGN) has recently been identified to play a crucial role in cell apoptosis, receptor signaling and differentiation.
Characterization of secretagogin-immunoreactive amacrine cells in marmoset retina.
Grünert et al., Sydney, Australia. In J Comp Neurol, 2014
In the present study the calcium-binding protein secretagogin was localized in a population of regular and displaced amacrine cells in the retina of the common marmoset Callithrix jacchus.
Revival of calcium-binding proteins for neuromorphology: secretagogin typifies distinct cell populations in the avian brain.
Alpár et al., Budapest, Hungary. In Brain Behav Evol, 2013
Secretagogin is a phylogenetically conserved Ca(2+)-binding protein, which marks neuronal populations largely distinct from other Ca(2+)-binding proteins in mammals.
Secretagogin-containing neurons in the mouse main olfactory bulb.
Kosaka et al., Fukuoka, Japan. In Neurosci Res, 2013
Secretagogin (SCGN) is a recently discovered calcium binding protein of the EF hand family.
The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice.
Itoh et al., Tokyo, Japan. In Faseb J, 2013
Secretagogin, an insulin vesicle docking protein, was up-regulated by 2.7-fold in Tg mice and in pancreatic MIN-6 cells overexpressing DDAH2.
Detectability of secretagogin in human erythrocytes.
Ang et al., Singapore, Singapore. In Neurosci Lett, 2012
While secretagogin mRNA was detected in both peripheral mononuclear cells and erythrocytes using reverse-transcription polymerase chain reaction, SCGN protein was only detected in erythrocytes.
Clusters of secretagogin-expressing neurons in the aged human olfactory tract lack terminal differentiation.
GeneRIF
Harkany et al., Newcastle upon Tyne, United Kingdom. In Proc Natl Acad Sci U S A, 2012
Data show that the density of secretagogin-positive neurons selectively decreases in the olfactory tract in Alzheimer's disease.
The renaissance of Ca2+-binding proteins in the nervous system: secretagogin takes center stage.
Review
Harkany et al., Aberdeen, United Kingdom. In Cell Signal, 2012
Secretagogin is a novel member of the group of EF-hand Ca(2+)-binding proteins whose expression precedes that of many other Ca(2+)-binding proteins in postmitotic, migratory neurons in the embryonic nervous system.
The usefulness of S100B, NSE, GFAP, NF-H, secretagogin and Hsp70 as a predictive biomarker of outcome in children with traumatic brain injury.
GeneRIF
Fedora et al., Brno, Czech Republic. In Acta Neurochir (wien), 2012
Levels of secretagogin correlate with mortality and are useful as predictors of outcome in children with traumatic brain injury.
Secretagogin is expressed in sensory CGRP neurons and in spinal cord of mouse and complements other calcium-binding proteins, with a note on rat and human.
Hökfelt et al., Harbin, China. In Mol Pain, 2011
BACKGROUND: Secretagogin (Scgn), a member of the EF-hand calcium-binding protein (CaBP) superfamily, has recently been found in subsets of developing and adult neurons.
Novel insights into the distribution and functional aspects of the calcium binding protein secretagogin from studies on rat brain and primary neuronal cell culture.
Tretter et al., Vienna, Austria. In Front Mol Neurosci, 2011
Secretagogin is a calcium binding protein (CBP) highly expressed in neuroendocrine cells.
Identification of a high-affinity network of secretagogin-binding proteins involved in vesicle secretion.
Linse et al., Lund, Sweden. In Mol Biosyst, 2011
Secretagogin is a hexa EF-hand Ca(2+)-binding protein expressed in neuroendocrine, pancreatic endocrine and retinal cells.
Expression of secretagogin in clear-cell renal cell carcinomas is associated with a high metastasis rate.
GeneRIF
Wagner et al., Vienna, Austria. In Hum Pathol, 2011
Ddetection of novel calcium-binding protein secretagogin within subgroup of clear-cell renal cell carcinomas. Increased metastasis rates within secretagogin-positive subgroup of clear-cell renal cell carcinomas.
Reduced secretagogin expression in the hippocampus of P301L tau transgenic mice.
Heikenwalder et al., Newcastle upon Tyne, United Kingdom. In J Neural Transm, 2011
Secretagogin is a newly described Ca2+ binding protein that is produced by pyramidal neurones of the human hippocampus.
Protein networks involved in vesicle fusion, transport, and storage revealed by array-based proteomics.
O'Connell et al., Lund, Sweden. In Methods Mol Biol, 2010
Secretagogin is a calcium-binding protein whose expression is characterised in neuroendocrine, pancreatic, and retinal cells.
Distribution patterns of calcium-binding proteins in pancreatic tissue of non-diabetic as well as type 2 diabetic rats and in rat insulinoma beta-cells (INS-1).
Peschke et al., Halle, Germany. In Histochem Cell Biol, 2010
Secretagogin was exclusively found within islets.
Secretagogin is a Ca2+-binding protein identifying prospective extended amygdala neurons in the developing mammalian telencephalon.
GeneRIF
Harkany et al., Aberdeen, United Kingdom. In Eur J Neurosci, 2010
Results emphasize the developmentally shared origins of neurons populating the extended amygdala, and suggest that secretagogin can be relevant to the generation of functional modalities in specific neuronal circuitries.
Expression of TAU in insulin-secreting cells and its interaction with the calcium-binding protein secretagogin.
GeneRIF
Wagner et al., Vienna, Austria. In J Endocrinol, 2010
There is an association of TAU and the calcium-binding protein SCGN in insulin-secreting cells implicating beta-cells as an extra cerebral site of tauopathy.
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