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Exocyst complex component 2

Sec5, Sec5p
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on Sec5
Model-based prediction of human hair color using DNA variants.
GeneRIF
Kayser et al., Kraków, Poland. In Hum Genet, 2011
Data show that Mc1R, HERC2, IRF4, TYR and EXOC2 are ranked highest in hair color prediction analysis.
Sec5, a member of the exocyst complex, mediates Drosophila embryo cellularization.
GeneRIF
Schwarz et al., Boston, United States. In Development, 2010
Sec5 concentrates at the sub-apical complex, indicating a role for Sec5 in the polarized epithelium.
Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis.
GeneRIF
Counter et al., Durham, United States. In Mol Cancer Res, 2010
shRNA-mediated knockdown of the Ral effector proteins Sec5 and Exo84, but less so in the case of RalBP1, reduced oncogenic RalGEF-mediated transformation and oncogenic Ras-driven tumorigenic growth of human cells.
Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration.
GeneRIF
Yeaman et al., Iowa City, United States. In J Cell Sci, 2008
Localization of Exocyst and, by extension, targeting of Exocyst-dependent cargo, is dependent on Ral GTPases, which control association between Sec5 and paxillin.
RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.
Impact
GeneRIF
White et al., Dallas, United States. In Cell, 2006
These observations define the mechanistic contribution of RalGTPases to cancer cell survival and reveal the RalB/Sec5 effector complex as a component of TBK1-dependent innate immune signaling.
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