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Exocyst complex component 2

Sec5, Sec5p
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: sec6, Sec8, Sec10, Exo70, Exo84
Papers on Sec5
RNA Silencing of Exocyst Genes in the Stigma Impairs the Acceptance of Compatible Pollen in Arabidopsis.
New
Goring et al., Toronto, Canada. In Plant Physiol, Dec 2015
Here, we investigated the functions of exocyst complex genes encoding the remaining seven subunits, SECRETORY3 (SEC3), SEC5, SEC6, SEC8, SEC10, SEC15, and EXO84, in Arabidopsis stigmas following compatible pollinations.
Developmentally distinct activities of the exocyst enable rapid cell elongation and determine meristem size during primary root growth in Arabidopsis.
Fowler et al., In Bmc Plant Biol, 2013
We evaluated Arabidopsis lines with mutations in four exocyst components (SEC5, SEC8, EXO70A1 and EXO84B) to explore exocyst function in primary root growth.
Arabidopsis exocyst subcomplex containing subunit EXO70B1 is involved in autophagy-related transport to the vacuole.
Zárský et al., Praha, Czech Republic. In Traffic, 2013
EXO70B1 interacts with SEC5 and EXO84 and forms an exocyst subcomplex involved in autophagy-related, Golgi-independent membrane traffic to the vacuole.
The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
Impact
Sablina et al., Leuven, Belgium. In Nat Cell Biol, 2013
The RAS-like GTPase RALB mediates cellular responses to nutrient availability or viral infection by respectively engaging two components of the exocyst complex, EXO84 and SEC5.
Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst.
Schwarz et al., Boston, United States. In Embo J, 2013
SSR growth requires Ral and the exocyst component Sec5 and Ral-induced enlargement of these membrane folds does not occur in sec5(-/-) muscles.
Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion.
Gaisano et al., Toronto, Canada. In Plos One, 2012
Sec5 protein depletion in rat INS-1 cells inhibited depolarization-induced release of primed insulin granules from both readily-releasable pool and mobilization from the reserve pool.
Model-based prediction of human hair color using DNA variants.
GeneRIF
Kayser et al., Kraków, Poland. In Hum Genet, 2011
Data show that Mc1R, HERC2, IRF4, TYR and EXOC2 are ranked highest in hair color prediction analysis.
Sec5, a member of the exocyst complex, mediates Drosophila embryo cellularization.
GeneRIF
Schwarz et al., Boston, United States. In Development, 2010
Sec5 concentrates at the sub-apical complex, indicating a role for Sec5 in the polarized epithelium.
Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis.
GeneRIF
Counter et al., Durham, United States. In Mol Cancer Res, 2010
shRNA-mediated knockdown of the Ral effector proteins Sec5 and Exo84, but less so in the case of RalBP1, reduced oncogenic RalGEF-mediated transformation and oncogenic Ras-driven tumorigenic growth of human cells.
Characterization of the Arabidopsis thaliana exocyst complex gene families by phylogenetic, expression profiling, and subcellular localization studies.
Goring et al., Toronto, Canada. In New Phytol, 2010
*The exocyst is a complex of eight proteins (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p and Exo84p) involved in tethering vesicles to the plasma membrane during regulated or polarized secretion.
Detection of epileptic-seizures by means of power spectrum analysis of heart rate variability: a pilot study.
Jasemian et al., Århus, Denmark. In Technol Health Care, 2009
ECG was continuously recorded and 30 min seizure-sessions (25-30 min pre-seizure to 30 sec-5 min post-seizure onset) and 30 min non-seizure-sessions (day- and night sessions for each patient, as control) were chosen for further HRV-analysis.
An internal domain of Exo70p is required for actin-independent localization and mediates assembly of specific exocyst components.
Novick et al., San Diego, United States. In Mol Biol Cell, 2009
The remaining domain, domain C, is not essential but when deleted, it leads to synthetic lethality with many secretory mutations, defects in exocyst assembly of exocyst components Sec5p and Sec6p, and loss of actin-independent localization.
Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration.
GeneRIF
Yeaman et al., Iowa City, United States. In J Cell Sci, 2008
Localization of Exocyst and, by extension, targeting of Exocyst-dependent cargo, is dependent on Ral GTPases, which control association between Sec5 and paxillin.
An exocyst complex functions in plant cell growth in Arabidopsis and tobacco.
Zárský et al., Praha, Czech Republic. In Plant Cell, 2008
Double mutants in exocyst subunits (sec5 exo70A1 and sec8 exo70A1) show a synergistic defect in etiolated hypocotyl elongation.
RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans.
Zwartkruis et al., Utrecht, Netherlands. In Embo J, 2008
Depletion of exoc-8 and sec-5, encoding two putative RAL-1 effectors and members of the exocyst complex, also caused lethality of rap-1 mutants, but did not affect wild-type worms.
Candida albicans hyphal morphogenesis occurs in Sec3p-independent and Sec3p-dependent phases separated by septin ring formation.
Wang et al., Singapore, Singapore. In J Cell Sci, 2007
Co-immunoprecipitation experiments detected association of the septin Cdc3p with the exocyst subunits Sec3p and Sec5p.
RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.
Impact
GeneRIF
White et al., Dallas, United States. In Cell, 2006
These observations define the mechanistic contribution of RalGTPases to cancer cell survival and reveal the RalB/Sec5 effector complex as a component of TBK1-dependent innate immune signaling.
Drosophila exocyst components Sec5, Sec6, and Sec15 regulate DE-Cadherin trafficking from recycling endosomes to the plasma membrane.
GeneRIF
Bellaïche et al., Paris, France. In Dev Cell, 2005
The Drosophila exocyst component sec5 in epithelial cells results in DE-Cad accumulation in an enlarged Rab11 recycling endosomal compartment and inhibits DE-Cad delivery to the membrane.
Glycosylation and processing of prepro-alpha-factor through the yeast secretory pathway.
Impact
Thorner et al., In Cell, 1984
Substantially greater amounts of the mature pheromone are seen in mutants that accumulate secretory vesicles (sec1, sec2, sec3, sec5).
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